Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity

One of the best known bioactive triterpenoids is oleanolic acid, a widespread 3-hydroxy-17-carboxy oleanane-type compound. In order to determine whether further oxidation of carbon 3 affects anti-inflammatory activity in mice, different tests were carried out on oleanolic acid and its 3-oxo-analogue...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2001-09, Vol.428 (1), p.137-143
Hauptverfasser:	Giner-Larza, Eva M, Máñez, Salvador, Recio, M.Carmen, Giner, Rosa M, Prieto, José M, Cerdá-Nicolás, Miguel, Rı́os, J.Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Blood Platelets - drug effects Blood Platelets - enzymology Cyclooxygenase Inhibitors - pharmacology Drug Screening Assays, Antitumor Ear, External - pathology Edema - chemically induced Edema - prevention & control Female Foot - pathology General pharmacology Humans Hypersensitivity, Delayed - prevention & control In Vitro Techniques Inflammation Inflammation - chemically induced Inflammation - pathology Inflammation - prevention & control Leukotriene Leukotriene B4 - biosynthesis Leukotrienes - biosynthesis Medical sciences Mice Neutrophils - drug effects Neutrophils - metabolism Oleanolic Acid - chemistry Oleanolic Acid - pharmacology Oleanonic acid Oxidation-Reduction Peroxidase - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Pistacia - chemistry Pistacia terebinthus Rats Skin Structure-Activity Relationship Tetrazolium Salts Thiazoles Triterpenes - chemistry Triterpenes - pharmacology Triterpenoid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!