Immune reconstitution: an important component of a successful allogeneic transplantation
The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) t...
Gespeichert in:
| Veröffentlicht in: | Immunology Letters 2000-11, Vol.74 (3), p.177-181 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 3 |
| container_start_page | 177 |
| container_title | Immunology Letters |
| container_volume | 74 |
| creator | Paloczi, Katalin |
| description | The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) the effects of graft versus host disease and its therapy, and (4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens. T-cell proliferation as well as immunoglobulin production remains impaired usually until the second half of the first year post-transplant. Other factors that can influence immunological reconstitution include the donor–recipient relationship (histocompatible or matched unrelated donor), intervening infections and recipient age, among others. |
| doi_str_mv | 10.1016/S0165-2478(00)00270-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72393672</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165247800002704</els_id><sourcerecordid>72393672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-81f33134e0cb2b5200a7aae3f0aff8eb11ce41af6f8cf59b935c22b4522e7d643</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhi1EBVvgJ4ByQu0hdPyROOGC0KotSEgcChI3y_GOK1eJvdhOJf59vR-iRy4zc3hm5tVDyDmFKwq0_farlKZmQnZfAL4CMAm1OCAL2sm-hkawQ7J4R47J55T-ANCGC35EjimFVkAvF-Tlfppmj1VEE3zKLs_ZBX9daV-5aR1i1j5XJpTRY5mCrXSVZmMwJTuPlR7H8Bs9OlPlqH1aj4XXmxOn5JPVY8KzfT8hzz--Py3v6ofHn_fL24fa8J7luqOWc8oFghnY0DAALbVGbkFb2-FAqUFBtW1tZ2zTDz1vDGODaBhDuWoFPyGXu7vrGF5nTFlNLhkcSxAMc1KS8Z63pX4EUtn2ALIvYLMDTQwpRbRqHd2k45uioDbu1da92ohVAGrrXm2SXOwfzMOEq_9be9kFuNkBWHz8dRhVMg69wZUr-rNaBffBi38cApVO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17690079</pqid></control><display><type>article</type><title>Immune reconstitution: an important component of a successful allogeneic transplantation</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Paloczi, Katalin</creator><creatorcontrib>Paloczi, Katalin</creatorcontrib><description>The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) the effects of graft versus host disease and its therapy, and (4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens. T-cell proliferation as well as immunoglobulin production remains impaired usually until the second half of the first year post-transplant. Other factors that can influence immunological reconstitution include the donor–recipient relationship (histocompatible or matched unrelated donor), intervening infections and recipient age, among others.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/S0165-2478(00)00270-4</identifier><identifier>PMID: 11064097</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Antibody Formation ; B-Lymphocyte Subsets - immunology ; BMT ; Cell Lineage ; Graft Survival - immunology ; Graft vs Host Disease - immunology ; Hematopoietic Stem Cell Transplantation ; Histocompatibility ; Humans ; Immunity, Cellular ; Immunocompetence ; Lymphocyte Activation ; Lymphocyte Count ; Lymphoid ontogeny ; Reconstitution ; T-Lymphocyte Subsets - immunology ; Time Factors ; Transplantation Conditioning ; Transplantation, Homologous - immunology ; Vaccination</subject><ispartof>Immunology Letters, 2000-11, Vol.74 (3), p.177-181</ispartof><rights>2000 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-81f33134e0cb2b5200a7aae3f0aff8eb11ce41af6f8cf59b935c22b4522e7d643</citedby><cites>FETCH-LOGICAL-c392t-81f33134e0cb2b5200a7aae3f0aff8eb11ce41af6f8cf59b935c22b4522e7d643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-2478(00)00270-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3550,27922,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11064097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paloczi, Katalin</creatorcontrib><title>Immune reconstitution: an important component of a successful allogeneic transplantation</title><title>Immunology Letters</title><addtitle>Immunol Lett</addtitle><description>The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) the effects of graft versus host disease and its therapy, and (4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens. T-cell proliferation as well as immunoglobulin production remains impaired usually until the second half of the first year post-transplant. Other factors that can influence immunological reconstitution include the donor–recipient relationship (histocompatible or matched unrelated donor), intervening infections and recipient age, among others.</description><subject>Adult</subject><subject>Antibody Formation</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>BMT</subject><subject>Cell Lineage</subject><subject>Graft Survival - immunology</subject><subject>Graft vs Host Disease - immunology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Histocompatibility</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunocompetence</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Count</subject><subject>Lymphoid ontogeny</subject><subject>Reconstitution</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Time Factors</subject><subject>Transplantation Conditioning</subject><subject>Transplantation, Homologous - immunology</subject><subject>Vaccination</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1EBVvgJ4ByQu0hdPyROOGC0KotSEgcChI3y_GOK1eJvdhOJf59vR-iRy4zc3hm5tVDyDmFKwq0_farlKZmQnZfAL4CMAm1OCAL2sm-hkawQ7J4R47J55T-ANCGC35EjimFVkAvF-Tlfppmj1VEE3zKLs_ZBX9daV-5aR1i1j5XJpTRY5mCrXSVZmMwJTuPlR7H8Bs9OlPlqH1aj4XXmxOn5JPVY8KzfT8hzz--Py3v6ofHn_fL24fa8J7luqOWc8oFghnY0DAALbVGbkFb2-FAqUFBtW1tZ2zTDz1vDGODaBhDuWoFPyGXu7vrGF5nTFlNLhkcSxAMc1KS8Z63pX4EUtn2ALIvYLMDTQwpRbRqHd2k45uioDbu1da92ohVAGrrXm2SXOwfzMOEq_9be9kFuNkBWHz8dRhVMg69wZUr-rNaBffBi38cApVO</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Paloczi, Katalin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Immune reconstitution: an important component of a successful allogeneic transplantation</title><author>Paloczi, Katalin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-81f33134e0cb2b5200a7aae3f0aff8eb11ce41af6f8cf59b935c22b4522e7d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Antibody Formation</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>BMT</topic><topic>Cell Lineage</topic><topic>Graft Survival - immunology</topic><topic>Graft vs Host Disease - immunology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Histocompatibility</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunocompetence</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Count</topic><topic>Lymphoid ontogeny</topic><topic>Reconstitution</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Time Factors</topic><topic>Transplantation Conditioning</topic><topic>Transplantation, Homologous - immunology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paloczi, Katalin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology Letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paloczi, Katalin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune reconstitution: an important component of a successful allogeneic transplantation</atitle><jtitle>Immunology Letters</jtitle><addtitle>Immunol Lett</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>74</volume><issue>3</issue><spage>177</spage><epage>181</epage><pages>177-181</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) the effects of graft versus host disease and its therapy, and (4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens. T-cell proliferation as well as immunoglobulin production remains impaired usually until the second half of the first year post-transplant. Other factors that can influence immunological reconstitution include the donor–recipient relationship (histocompatible or matched unrelated donor), intervening infections and recipient age, among others.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11064097</pmid><doi>10.1016/S0165-2478(00)00270-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology Letters, 2000-11, Vol.74 (3), p.177-181 |
| issn | 0165-2478 1879-0542 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72393672 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Antibody Formation B-Lymphocyte Subsets - immunology BMT Cell Lineage Graft Survival - immunology Graft vs Host Disease - immunology Hematopoietic Stem Cell Transplantation Histocompatibility Humans Immunity, Cellular Immunocompetence Lymphocyte Activation Lymphocyte Count Lymphoid ontogeny Reconstitution T-Lymphocyte Subsets - immunology Time Factors Transplantation Conditioning Transplantation, Homologous - immunology Vaccination |
| title | Immune reconstitution: an important component of a successful allogeneic transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T17%3A21%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20reconstitution:%20an%20important%20component%20of%20a%20successful%20allogeneic%20transplantation&rft.jtitle=Immunology%20Letters&rft.au=Paloczi,%20Katalin&rft.date=2000-11-01&rft.volume=74&rft.issue=3&rft.spage=177&rft.epage=181&rft.pages=177-181&rft.issn=0165-2478&rft.eissn=1879-0542&rft_id=info:doi/10.1016/S0165-2478(00)00270-4&rft_dat=%3Cproquest_cross%3E72393672%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17690079&rft_id=info:pmid/11064097&rft_els_id=S0165247800002704&rfr_iscdi=true |