Severe bronchiolitis in acute Mycoplasma pneumoniae infection
We report on a 17-year-old patient with severe bronchiolitis due to Mycoplasma pneumoniae infection. Despite an early 10-day course of clarithromycin, she developed progressive dyspnea, cough, fever, and severe obstructive ventilatory impairment. Sixteen days after onset of the disease a severe hemo...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2001-12, Vol.439 (6), p.818-822 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | EBNÖTHER, M SCHOENENBERGER, R. A PERRUCHOUD, A. P SOLER, M GUDAT, F DALQUEN, P |
| description | We report on a 17-year-old patient with severe bronchiolitis due to Mycoplasma pneumoniae infection. Despite an early 10-day course of clarithromycin, she developed progressive dyspnea, cough, fever, and severe obstructive ventilatory impairment. Sixteen days after onset of the disease a severe hemolytic anemia developed with only cold agglutinins positive at serologic screening. Thoracoscopic lung biopsy revealed diffuse bronchiolitis with suppurative intrabronchiolar inflammation, lymphohistiocytic "cuffing" of the bronchioli, and foam cell aggregates within neighboring alveoli. The infiltrate consisted mainly of CD3+, CD8+ lymphocytes and CD68+ macrophages. The diagnosis of Mycoplasma pneumoniae bronchiolitis was based on repeated complement fixation tests, which turned strongly positive only at day 74 after onset of the disease. Pulmonary function improved slowly under long-term prednisone treatment. |
| doi_str_mv | 10.1007/s004280100473 |
| format | Article |
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The diagnosis of Mycoplasma pneumoniae bronchiolitis was based on repeated complement fixation tests, which turned strongly positive only at day 74 after onset of the disease. Pulmonary function improved slowly under long-term prednisone treatment.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s004280100473</identifier><identifier>PMID: 11787856</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acute Disease ; Adolescent ; Anemia, Hemolytic - microbiology ; Anti-Bacterial Agents - therapeutic use ; Antigens, CD - analysis ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Biological and medical sciences ; Bronchiolitis - drug therapy ; Bronchiolitis - microbiology ; Bronchiolitis - pathology ; Bronchoalveolar Lavage Fluid - cytology ; Clarithromycin - therapeutic use ; Complement Fixation Tests ; Drug Therapy, Combination ; Female ; Glucocorticoids - therapeutic use ; Human bacterial diseases ; Humans ; Infectious diseases ; Lymphocytes - chemistry ; Lymphocytes - pathology ; Macrophages - chemistry ; Macrophages - pathology ; Medical sciences ; Mycoplasma pneumoniae - isolation & purification ; Pneumonia, Mycoplasma - drug therapy ; Pneumonia, Mycoplasma - microbiology ; Pneumonia, Mycoplasma - pathology ; Prednisone - therapeutic use ; Radiography, Thoracic ; Respiratory Function Tests ; Tomography, X-Ray Computed</subject><ispartof>Virchows Archiv : an international journal of pathology, 2001-12, Vol.439 (6), p.818-822</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-9ba0e05999d1a4c03c3d4a9ed7d31f552cca8387bfdca4f3be334645972edbc83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14131176$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11787856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EBNÖTHER, M</creatorcontrib><creatorcontrib>SCHOENENBERGER, R. 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The infiltrate consisted mainly of CD3+, CD8+ lymphocytes and CD68+ macrophages. The diagnosis of Mycoplasma pneumoniae bronchiolitis was based on repeated complement fixation tests, which turned strongly positive only at day 74 after onset of the disease. Pulmonary function improved slowly under long-term prednisone treatment.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Anemia, Hemolytic - microbiology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antigens, CD - analysis</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Biological and medical sciences</subject><subject>Bronchiolitis - drug therapy</subject><subject>Bronchiolitis - microbiology</subject><subject>Bronchiolitis - pathology</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Clarithromycin - therapeutic use</subject><subject>Complement Fixation Tests</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lymphocytes - chemistry</subject><subject>Lymphocytes - pathology</subject><subject>Macrophages - chemistry</subject><subject>Macrophages - pathology</subject><subject>Medical sciences</subject><subject>Mycoplasma pneumoniae - isolation & purification</subject><subject>Pneumonia, Mycoplasma - drug therapy</subject><subject>Pneumonia, Mycoplasma - microbiology</subject><subject>Pneumonia, Mycoplasma - pathology</subject><subject>Prednisone - therapeutic use</subject><subject>Radiography, Thoracic</subject><subject>Respiratory Function Tests</subject><subject>Tomography, X-Ray Computed</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0M1LxDAQBfAgiruuHr1KL3qrJpm0SQ4eZPELVjyo55KmU4y0TU1aYf97K1tYPM2D-fEOj5BzRq8ZpfImUiq4olMWEg7IkgngKQcqD8mSapGlOTC5ICcxflHKmWL5MVkwJpVUWb4kt2_4gwGTMvjOfjrfuMHFxHWJseOAycvW-r4xsTVJ3-HY-s4ZnN412sH57pQc1aaJeDbfFfl4uH9fP6Wb18fn9d0mtaCyIdWloUgzrXXFjLAULFTCaKxkBazOMm6tUaBkWVfWiBpKBBC5yLTkWJVWwYpc7Xr74L9HjEPRumixaUyHfoyF5KC5yvMJpjtog48xYF30wbUmbAtGi7-9in97Tf5iLh7LFqu9ngeawOUMTLSmqYPprIt7JxhMNodfShFyrQ</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>EBNÖTHER, M</creator><creator>SCHOENENBERGER, R. 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A</creatorcontrib><creatorcontrib>PERRUCHOUD, A. P</creatorcontrib><creatorcontrib>SOLER, M</creatorcontrib><creatorcontrib>GUDAT, F</creatorcontrib><creatorcontrib>DALQUEN, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EBNÖTHER, M</au><au>SCHOENENBERGER, R. A</au><au>PERRUCHOUD, A. 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Thoracoscopic lung biopsy revealed diffuse bronchiolitis with suppurative intrabronchiolar inflammation, lymphohistiocytic "cuffing" of the bronchioli, and foam cell aggregates within neighboring alveoli. The infiltrate consisted mainly of CD3+, CD8+ lymphocytes and CD68+ macrophages. The diagnosis of Mycoplasma pneumoniae bronchiolitis was based on repeated complement fixation tests, which turned strongly positive only at day 74 after onset of the disease. Pulmonary function improved slowly under long-term prednisone treatment.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11787856</pmid><doi>10.1007/s004280100473</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Disease Adolescent Anemia, Hemolytic - microbiology Anti-Bacterial Agents - therapeutic use Antigens, CD - analysis Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Bronchiolitis - drug therapy Bronchiolitis - microbiology Bronchiolitis - pathology Bronchoalveolar Lavage Fluid - cytology Clarithromycin - therapeutic use Complement Fixation Tests Drug Therapy, Combination Female Glucocorticoids - therapeutic use Human bacterial diseases Humans Infectious diseases Lymphocytes - chemistry Lymphocytes - pathology Macrophages - chemistry Macrophages - pathology Medical sciences Mycoplasma pneumoniae - isolation & purification Pneumonia, Mycoplasma - drug therapy Pneumonia, Mycoplasma - microbiology Pneumonia, Mycoplasma - pathology Prednisone - therapeutic use Radiography, Thoracic Respiratory Function Tests Tomography, X-Ray Computed |
| title | Severe bronchiolitis in acute Mycoplasma pneumoniae infection |
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