VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis

Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-β (IFN-β) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-1) on fresh T lymphocyte subpopulations from 5 MS patients monthly...

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Veröffentlicht in:	Journal of neuroimmunology 2000-11, Vol.111 (1), p.186-194
Hauptverfasser:	Muraro, P.A, Leist, T, Bielekova, B, McFarland, H.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecules Adjuvants, Immunologic - administration & dosage Antigens, CD - immunology Antigens, CD - metabolism b-Interferon Biomarkers CD4 Antigens - analysis CD49d antigen CD58 Antigens - analysis CD8 Antigens - analysis Down-Regulation - immunology Female Flow Cytometry HLA-DR Antigens - analysis Humans Immunologic Memory - drug effects Immunologic Memory - immunology Integrin alpha4 Integrin alpha4beta1 Integrin beta1 - analysis Integrins - immunology Integrins - metabolism Intercellular Adhesion Molecule-1 - analysis Interferon-beta - administration & dosage Interferon-β Leukocyte Common Antigens - analysis Lymphocyte Function-Associated Antigen-1 - analysis Magnetic Resonance Imaging Male Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - immunology Receptors, Lymphocyte Homing - immunology Receptors, Lymphocyte Homing - metabolism T lymphocytes T-Lymphocytes - chemistry T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis VLA-4
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