Human immunodeficiency virus type 1-mediated syncytium formation is compatible with adenovirus replication and facilitates efficient dispersion of viral gene products and de novo-synthesized virus particles

Conditionally replicative adenovirus (CRAd) vectors are designed for specific oncolytic replication in tumor tissues with concomitant sparing of normal cells. As such, CRAds offer an unprecedented level of anticancer potential for malignancies that have been refractory to previous cancer gene therap...

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Veröffentlicht in:	Human gene therapy 2001-12, Vol.12 (18), p.2155-2165
Hauptverfasser:	HUI LI, HAVIV, Yosef S, DERDEYN, Cynthia A, LAM, John, COOLIDGE, Candace, HUNTER, Eric, CURIEL, David T, BLACKWELL, Jerry L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenoviruses, Human - physiology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Biotechnology CD4 antigen CD4 Antigens - genetics Coxsackie and Adenovirus Receptor-Like Membrane Protein Fundamental and applied biological sciences. Psychology Gene Expression Gene Products, env - biosynthesis Gene Products, env - genetics Gene Products, env - physiology Gene therapy Genes, Viral Genetic Vectors - physiology Giant Cells Health. Pharmaceutical industry HeLa Cells HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Humans Industrial applications and implications. Economical aspects Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Receptors, Virus - biosynthesis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Virion Virus Assembly - physiology Virus Replication
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