Roles for Zebrafish Focal Adhesion Kinase in Notochord and Somite Morphogenesis

We have cloned zebrafish focal adhesion kinase (Fak) and analyzed its subcellular localization. Fak protein is localized at the cortex of notochord cells and at the notochord–somite boundary. During somitogenesis, Fak protein becomes concentrated at the basal region of epithelial cells at intersomit...

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Veröffentlicht in:	Developmental biology 2001-12, Vol.240 (2), p.474-487
Hauptverfasser:	Henry, Clarissa A., Crawford, Bryan D., Yan, Yi-Lin, Postlethwait, John, Cooper, Mark S., Hille, Merrill B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Body Patterning Chromosome Mapping Cloning, Molecular DNA, Complementary - genetics focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases fused-somite Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic knypek Membrane Proteins - physiology Molecular Sequence Data Morphogenesis Mutation Notch notochord Notochord - embryology Notochord - enzymology Phosphorylation Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - physiology Receptors, Notch RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid Signal Transduction Somites - cytology Somites - enzymology somitogenesis trilobite zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism
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