Ptc1 and Ptc2 Transcripts Provide Distinct Readouts of Hedgehog Signaling Activity during Chick Embryogenesis

Hedgehog (Hh) signaling in vertebrates controls patterning and differentiation of a broad range of tissues during development. The Hh receptor Patched (Ptc) is a critical regulator of signaling, maintaining active repression of the pathway in the absence of stimulation, limiting excess diffusion of...

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Veröffentlicht in:	Developmental biology 2001-11, Vol.239 (1), p.15-29
Hauptverfasser:	Pearse, Richard V., Vogan, Kyle J., Tabin, Clifford J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AER Amino Acid Sequence Animals Avian Proteins - genetics Avian Proteins - metabolism BMP antagonism Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - metabolism chick Chick Embryo - embryology Chick Embryo - metabolism Cloning, Molecular Ectoderm - metabolism Fgf4 gene Gallus gallus Gene Expression Regulation, Developmental hedgehog Hedgehog protein Hedgehog Proteins Humans In Situ Hybridization left–right asymmetry limb bud Limb Buds - embryology Limb Buds - metabolism Membrane Proteins - chemistry Membrane Proteins - genetics Molecular Sequence Data node patched Patched protein Patched Receptors Phylogeny Ptc1 gene Ptc2 gene Receptors, Cell Surface RNA, Messenger - analysis RNA, Messenger - genetics Sequence Homology, Amino Acid Signal Transduction Trans-Activators - antagonists & inhibitors Trans-Activators - metabolism Transcription, Genetic - genetics Transforming Growth Factor beta
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