Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases

Prion propagation in transmissible spongiform encephalopathies involves the conversion of cellular prion protein, PrP(C), into a pathogenic conformer, PrP(Sc). Hereditary forms of the disease are linked to specific mutations in the gene coding for the prion protein. To gain insight into the molecula...

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Veröffentlicht in:	The Journal of biological chemistry 2000-10, Vol.275 (43), p.33650-33654
Hauptverfasser:	Zhang, Y, Swietnicki, W, Zagorski, M G, Surewicz, W K, Sönnichsen, F D
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Creutzfeldt-Jakob Syndrome - genetics Humans Molecular Sequence Data Mutation Prions - chemistry Protein Folding Protein Structure, Secondary PrP protein Solutions spongiform encephalopathy
Online-Zugang:	Volltext
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