The iron chelator pyridoxal isonicotinoyl hydrazone inhibits mitochondrial lipid peroxidation induced by Fe(II)–citrate

Pyridoxal isonicotinoyl hydrazone (PIH) is able to prevent iron-mediated hydroxyl radical formation by means of iron chelation and inhibition of redox cycling of the metal. In this study, we investigated the effect of PIH on Fe(II)–citrate-mediated lipid peroxidation and damage to isolated rat liver...

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Veröffentlicht in:	European journal of pharmacology 2001-09, Vol.428 (1), p.37-44
Hauptverfasser:	Santos, Natacha C.F, Castilho, Roger F, Meinicke, André R, Hermes-Lima, Marcelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Biological and medical sciences Chelating Agents - pharmacology Ferric Compounds - antagonists & inhibitors Ferric Compounds - pharmacology Free radical General and cellular metabolism. Vitamins In Vitro Techniques Indicators and Reagents Iron - chemistry Iron Chelating Agents - pharmacology Iron chelator Isoniazid - analogs & derivatives Isoniazid - pharmacology Lipid peroxidation Lipid Peroxidation - drug effects Medical sciences Membrane Potentials - drug effects Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Oxidation-Reduction Oxidative stress Oxygen Consumption - drug effects Pharmacology. Drug treatments Pyridoxal - analogs & derivatives Pyridoxal - pharmacology Pyridoxal isonicotinoyl hydrazone Rats Thiobarbituric Acid Reactive Substances - metabolism
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