A Region Upstream of the Human δ-Globin Gene Shows a Stage-Specific Interaction with Globin Promoters in Erythroid Cell Lines

ABSTRACT We previously showed that the 651-bp DNA fragment, located 3 kb upstream from the human |gd-globin gene (fragment F5), is able to inhibit adult, not fetal, globin promoter in mouse erythroleukemia cell lines (MEL) expressing adult globin genes. Here we show in transient analysis that fragme...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2001-09, Vol.27 (5), p.874-881
Hauptverfasser:	Vitale, Maria, Calzolari, Roberta, Di Marzo, Rosalba, Acuto, Santina, Maggio, Aurelio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites DNA Footprinting DNA-Binding Proteins - metabolism Erythroid Precursor Cells - metabolism Fetal Proteins - genetics Gene Expression Regulation, Developmental - genetics Globins - genetics Humans Mice Promoter Regions, Genetic - genetics Transfection Tumor Cells, Cultured
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