An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C
The aim was to assess the validity of a digitally computed fibrosis ratio as a measure of fibrosis stage in liver biopsy specimens. We scored 230 liver biopsy specimens from patients with chronic hepatitis C for fibrosis using modified Knodell criteria; fibrosis ratios were computed from digital ima...
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| Veröffentlicht in: | American journal of clinical pathology 2000-11, Vol.114 (5), p.712-718 |
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| container_title | American journal of clinical pathology |
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| creator | O'BRIEN, Michael J KEATING, Norris M ELDERINY, Salah CERDA, Sandra KEAVENY, Andrew P AFDHAL, Nezam H NUNES, David P |
| description | The aim was to assess the validity of a digitally computed fibrosis ratio as a measure of fibrosis stage in liver biopsy specimens. We scored 230 liver biopsy specimens from patients with chronic hepatitis C for fibrosis using modified Knodell criteria; fibrosis ratios were computed from digital images that encompassed the complete trichrome-stained section of each case. Although an overall correlation between fibrosis ratio and ordinal score was present, subset analysis showed that this correlation existed only among biopsy specimens with high scores (3-6, early bridging fibrosis to established cirrhosis). There was no correlation or difference between category means found among biopsy specimens with low scores (0-3, normal to early bridging fibrosis). Furthermore, concordance by both estimates in direction of fibrosis change among serial liver biopsy specimens was found in only 11 (30%) of 37 pairs compared. The findings suggest that a qualitative assessment of the computerized fibrosis pattern is necessary for the interpretation of computerized fibrosis ratio measurements, particularly in patients with early stage fibrosis. |
| doi_str_mv | 10.1309/D7AU-EYW7-4B6C-K08Y |
| format | Article |
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We scored 230 liver biopsy specimens from patients with chronic hepatitis C for fibrosis using modified Knodell criteria; fibrosis ratios were computed from digital images that encompassed the complete trichrome-stained section of each case. Although an overall correlation between fibrosis ratio and ordinal score was present, subset analysis showed that this correlation existed only among biopsy specimens with high scores (3-6, early bridging fibrosis to established cirrhosis). There was no correlation or difference between category means found among biopsy specimens with low scores (0-3, normal to early bridging fibrosis). Furthermore, concordance by both estimates in direction of fibrosis change among serial liver biopsy specimens was found in only 11 (30%) of 37 pairs compared. The findings suggest that a qualitative assessment of the computerized fibrosis pattern is necessary for the interpretation of computerized fibrosis ratio measurements, particularly in patients with early stage fibrosis.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/D7AU-EYW7-4B6C-K08Y</identifier><identifier>PMID: 11068544</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Biological and medical sciences ; Biopsy ; Hepatitis C virus ; Hepatitis C, Chronic - pathology ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Liver Cirrhosis - classification ; Liver Cirrhosis - pathology ; Medical sciences ; Middle Aged ; Miscellaneous. Technology ; Pathology. Cytology. Biochemistry. Spectrometry. 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We scored 230 liver biopsy specimens from patients with chronic hepatitis C for fibrosis using modified Knodell criteria; fibrosis ratios were computed from digital images that encompassed the complete trichrome-stained section of each case. Although an overall correlation between fibrosis ratio and ordinal score was present, subset analysis showed that this correlation existed only among biopsy specimens with high scores (3-6, early bridging fibrosis to established cirrhosis). There was no correlation or difference between category means found among biopsy specimens with low scores (0-3, normal to early bridging fibrosis). Furthermore, concordance by both estimates in direction of fibrosis change among serial liver biopsy specimens was found in only 11 (30%) of 37 pairs compared. The findings suggest that a qualitative assessment of the computerized fibrosis pattern is necessary for the interpretation of computerized fibrosis ratio measurements, particularly in patients with early stage fibrosis.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver Cirrhosis - classification</subject><subject>Liver Cirrhosis - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Technology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Reproducibility of Results</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvLL0BCPiBuAX_EcXxclvIhKnFphXqyJs6ka5QvPFmq5dfXUVfqEV9GHj3zSjMPY2-k-CC1cB8_2-1NcXn7yxblp2pX_BD17TO2ka7UhbVKPWcbIYQqnLT6jL0i-i2EVLUoX7IzKUVVm7LcsH_bkQMREg04LnzqeBvv4gI9jwPcIYcR-iNF4svEBwQ6JORdbNK09uLI-_gXE2_iNNOR04wh5hxac2ZYYo4kfh-XPQ_7NI0x8D2u_SUP7y7Yiw56wtenes5uvlxe774VVz-_ft9tr4pQimopOuNcMMaAQ6iUboXSXQ0NyLyNagHzKko1Nv-hhoANGIEVggqNsa3uQJ-z94-5c5r-HJAWP0QK2Pcw4nQgb5Wu83P_BWWtXOmsyaB-BEO-AyXs_JzyudLRS-FXN35141c3fnXjVzd56u0p_tAM2D7NnGRk4N0JAArQdwnGEOmJM9o4XeoHYy2avw</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>O'BRIEN, Michael J</creator><creator>KEATING, Norris M</creator><creator>ELDERINY, Salah</creator><creator>CERDA, Sandra</creator><creator>KEAVENY, Andrew P</creator><creator>AFDHAL, Nezam H</creator><creator>NUNES, David P</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C</title><author>O'BRIEN, Michael J ; KEATING, Norris M ; ELDERINY, Salah ; CERDA, Sandra ; KEAVENY, Andrew P ; AFDHAL, Nezam H ; NUNES, David P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-f599c555a9ea623d023f8aba10122dae10622b7a10a8aceba50e6ea2cb57d3fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver Cirrhosis - classification</topic><topic>Liver Cirrhosis - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Technology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'BRIEN, Michael J</creatorcontrib><creatorcontrib>KEATING, Norris M</creatorcontrib><creatorcontrib>ELDERINY, Salah</creatorcontrib><creatorcontrib>CERDA, Sandra</creatorcontrib><creatorcontrib>KEAVENY, Andrew P</creatorcontrib><creatorcontrib>AFDHAL, Nezam H</creatorcontrib><creatorcontrib>NUNES, David P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'BRIEN, Michael J</au><au>KEATING, Norris M</au><au>ELDERINY, Salah</au><au>CERDA, Sandra</au><au>KEAVENY, Andrew P</au><au>AFDHAL, Nezam H</au><au>NUNES, David P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>114</volume><issue>5</issue><spage>712</spage><epage>718</epage><pages>712-718</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>The aim was to assess the validity of a digitally computed fibrosis ratio as a measure of fibrosis stage in liver biopsy specimens. We scored 230 liver biopsy specimens from patients with chronic hepatitis C for fibrosis using modified Knodell criteria; fibrosis ratios were computed from digital images that encompassed the complete trichrome-stained section of each case. Although an overall correlation between fibrosis ratio and ordinal score was present, subset analysis showed that this correlation existed only among biopsy specimens with high scores (3-6, early bridging fibrosis to established cirrhosis). There was no correlation or difference between category means found among biopsy specimens with low scores (0-3, normal to early bridging fibrosis). Furthermore, concordance by both estimates in direction of fibrosis change among serial liver biopsy specimens was found in only 11 (30%) of 37 pairs compared. The findings suggest that a qualitative assessment of the computerized fibrosis pattern is necessary for the interpretation of computerized fibrosis ratio measurements, particularly in patients with early stage fibrosis.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>11068544</pmid><doi>10.1309/D7AU-EYW7-4B6C-K08Y</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of clinical pathology, 2000-11, Vol.114 (5), p.712-718 |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Oxford Journals |
| subjects | Biological and medical sciences Biopsy Hepatitis C virus Hepatitis C, Chronic - pathology Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Liver Cirrhosis - classification Liver Cirrhosis - pathology Medical sciences Middle Aged Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reproducibility of Results |
| title | An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C |
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