Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH −/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreo...

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Veröffentlicht in:	Nature medicine 2000-11, Vol.6 (11), p.1229-1234
Hauptverfasser:	Lagasse, Eric, Connors, Heather, Al-Dhalimy, Muhsen, Reitsma, Michael, Dohse, Monika, Osborne, Linda, Wang, Xin, Finegold, Milton, Weissman, Irving L, Grompe, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - cytology Cancer Research Cell Differentiation Cell Separation - methods Cell Transplantation Cellular therapy Enzymes Genetic aspects Health aspects Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hepatocytes - cytology Hydrolases - deficiency Infectious Diseases Injection Liver Liver - pathology Liver cells Liver diseases Liver Regeneration Medicine Metabolic Diseases Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Molecular Medicine Neurosciences Stem cell transplantation Stem cells Tyrosinemias - genetics Tyrosinemias - pathology Tyrosinemias - therapy Whole-Body Irradiation
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