in vivo inhibition of PC‐3 human androgen‐independent prostate cancer by a targeted cytotoxic bombesin analogue, AN‐215

The effectiveness of chemotherapy targeted to bombesin (BN) receptors was evaluated in nude mice bearing PC‐3 human androgen‐independent prostate cancers. Cytotoxic BN analogue AN‐215, consisting of 2‐pyrrolinodoxorubicin (AN‐201) linked to BN‐like carrier peptide RC‐3094, was injected i.v. at 150 n...

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Veröffentlicht in:	International journal of cancer 2000-11, Vol.88 (4), p.652-657
Hauptverfasser:	Plonowski, Artur, Nagy, Attila, Schally, Andrew V., Sun, Baodong, Groot, Kate, Halmos, Gabor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Bombesin - analogs & derivatives Bombesin - pharmacokinetics Bombesin - therapeutic use Carboxylic Ester Hydrolases - antagonists & inhibitors Carboxylic Ester Hydrolases - blood Chemotherapy Doxorubicin - analogs & derivatives Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Humans Male Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Pyrroles - therapeutic use Receptors, Bombesin - analysis Tumor Cells, Cultured Xenograft Model Antitumor Assays
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