Why Is p53 Acetylated?

Why Is p53 Acetylated?

Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.

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Bibliographische Detailangaben
Veröffentlicht in:Cell 2001-12, Vol.107 (7), p.815-818
Hauptverfasser: Prives, Carol, Manley, James L.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Animals
Cell Cycle
Cell Death
DNA Repair
Genes, Tumor Suppressor
Humans
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Beschreibung
Zusammenfassung:Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(01)00619-5