A Sequence-Ready PAC Contig of a 550-kb Region on Rat Chromosome 4 Including the Diabetes Susceptibility Gene Lyp

The Lyp locus controls diabetes development in rats. The diabetogenic allele in diabetes-prone BB rats is responsible for T cell lymphopenia characterized by the absence of regulatory T cells. We present refined genetic and radiation hybrid maps of the Lyp region on rat chromosome 4, a single 800-kb...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2000-11, Vol.69 (3), p.305-313
Hauptverfasser:	Hornum, Lars, Markholst, Helle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromosome 4 Chromosomes, Artificial, Bacterial Chromosomes, Artificial, Yeast Classical genetics, quantitative genetics, hybrids Contig Mapping Cricetinae Diabetes Mellitus, Type 1 - genetics Expressed Sequence Tags Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - genetics Genetics of eukaryotes. Biological and molecular evolution Humans Lyp gene Male Mice Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases - genetics Rats Rats, Inbred BB Rats, Inbred BN Vertebrata
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