Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou
To investigate the prevalence of sinonasal lymphoepithelial carcinoma (SNLEC) in Guangzhou, a high incidence area of nasopharyngeal carcinoma (NPC), and to detect whether it is associated with Epstein-Barr virus (EBV) infection. Twenty confirmed SNLEC specimens were collected from all of the sinonas...
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| Veröffentlicht in: | Chinese medical journal 2001-02, Vol.114 (2), p.132-136 |
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| description | To investigate the prevalence of sinonasal lymphoepithelial carcinoma (SNLEC) in Guangzhou, a high incidence area of nasopharyngeal carcinoma (NPC), and to detect whether it is associated with Epstein-Barr virus (EBV) infection.
Twenty confirmed SNLEC specimens were collected from all of the sinonasal carcinoma biopsies performed in the 8 years 1989-1996 at the Sun Yat-sen University of Medical Sciences. EBV encoded early RNAs were detected by use of in-situ hybridization. A variety of antigens, including the EBV nuclear antigen 1, latent membrane protein 1, BZLF1 protein, diffuse early antigen, viral capsid antigen and membrane antigen, were detected using immunohistochemistry. Additionally, 36 NPC specimens were used for comparison.
Twenty SNLECs were identified. Seventeen SNLECs were developed in the nasal cavity, and 3 in the maxillary sinus. The mean age (46.25 y), male to female ratio (3:1), histopathology and lymphoinfiltration of the 20 SNLECs were identical with those of the 36 NPCs. Thirteen (65.0%) of the 20 SNLECs showed an expansive growth pattern, while 27 (75.0%) of the 36 NPCs showed an infiltrating or mixed growth pattern. The majority of cancer cells in all of the 20 SNLECs showed EBV encoded early RNAs. The EBV nuclear antigen 1 expression of SNLEC was less intensive than that of NPC. The expression rate of latent membrane protein 1 for SNLEC (3/20, 15%) was lower than that for NPC (19/36, 52.8%). The expression rates of BZLF1 protein (2/20, 10.0%), diffuse early antigen (19/20, 95.0%), viral capsid antigen (15/20, 75.0%), and membrane antigen (13/20, 65.0%) for SNLEC were higher than those (0/36, 0.0%; 31/36, 86.0%; 18/36, 50%; and 14/36, 38.9%) for NPC.
SNLEC is not uncommon in Guangzhou. This tumour is also consistently associated with EBV infection like NPC. As compared to NPC, the EBV harbored in SNLECs seems to express the EBV nuclear antigen 1 weakly and has a lower expression rate of latent membrane protein 1 as well as higher expression rates of EBV lytic products. |
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Twenty confirmed SNLEC specimens were collected from all of the sinonasal carcinoma biopsies performed in the 8 years 1989-1996 at the Sun Yat-sen University of Medical Sciences. EBV encoded early RNAs were detected by use of in-situ hybridization. A variety of antigens, including the EBV nuclear antigen 1, latent membrane protein 1, BZLF1 protein, diffuse early antigen, viral capsid antigen and membrane antigen, were detected using immunohistochemistry. Additionally, 36 NPC specimens were used for comparison.
Twenty SNLECs were identified. Seventeen SNLECs were developed in the nasal cavity, and 3 in the maxillary sinus. The mean age (46.25 y), male to female ratio (3:1), histopathology and lymphoinfiltration of the 20 SNLECs were identical with those of the 36 NPCs. Thirteen (65.0%) of the 20 SNLECs showed an expansive growth pattern, while 27 (75.0%) of the 36 NPCs showed an infiltrating or mixed growth pattern. The majority of cancer cells in all of the 20 SNLECs showed EBV encoded early RNAs. The EBV nuclear antigen 1 expression of SNLEC was less intensive than that of NPC. The expression rate of latent membrane protein 1 for SNLEC (3/20, 15%) was lower than that for NPC (19/36, 52.8%). The expression rates of BZLF1 protein (2/20, 10.0%), diffuse early antigen (19/20, 95.0%), viral capsid antigen (15/20, 75.0%), and membrane antigen (13/20, 65.0%) for SNLEC were higher than those (0/36, 0.0%; 31/36, 86.0%; 18/36, 50%; and 14/36, 38.9%) for NPC.
SNLEC is not uncommon in Guangzhou. This tumour is also consistently associated with EBV infection like NPC. As compared to NPC, the EBV harbored in SNLECs seems to express the EBV nuclear antigen 1 weakly and has a lower expression rate of latent membrane protein 1 as well as higher expression rates of EBV lytic products.</description><identifier>ISSN: 0366-6999</identifier><identifier>PMID: 11780191</identifier><language>eng</language><publisher>China</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - complications ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; China - epidemiology ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - virology ; Female ; Herpesvirus 4, Human - genetics ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Male ; Middle Aged ; Paranasal Sinus Neoplasms - complications ; Paranasal Sinus Neoplasms - epidemiology ; Paranasal Sinus Neoplasms - pathology ; Viral Proteins - analysis ; Viral Proteins - genetics</subject><ispartof>Chinese medical journal, 2001-02, Vol.114 (2), p.132-136</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11780191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zong, Y</creatorcontrib><creatorcontrib>Liu, K</creatorcontrib><creatorcontrib>Zhong, B</creatorcontrib><creatorcontrib>Chen, G</creatorcontrib><creatorcontrib>Wu, W</creatorcontrib><title>Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou</title><title>Chinese medical journal</title><addtitle>Chin Med J (Engl)</addtitle><description>To investigate the prevalence of sinonasal lymphoepithelial carcinoma (SNLEC) in Guangzhou, a high incidence area of nasopharyngeal carcinoma (NPC), and to detect whether it is associated with Epstein-Barr virus (EBV) infection.
Twenty confirmed SNLEC specimens were collected from all of the sinonasal carcinoma biopsies performed in the 8 years 1989-1996 at the Sun Yat-sen University of Medical Sciences. EBV encoded early RNAs were detected by use of in-situ hybridization. A variety of antigens, including the EBV nuclear antigen 1, latent membrane protein 1, BZLF1 protein, diffuse early antigen, viral capsid antigen and membrane antigen, were detected using immunohistochemistry. Additionally, 36 NPC specimens were used for comparison.
Twenty SNLECs were identified. Seventeen SNLECs were developed in the nasal cavity, and 3 in the maxillary sinus. The mean age (46.25 y), male to female ratio (3:1), histopathology and lymphoinfiltration of the 20 SNLECs were identical with those of the 36 NPCs. Thirteen (65.0%) of the 20 SNLECs showed an expansive growth pattern, while 27 (75.0%) of the 36 NPCs showed an infiltrating or mixed growth pattern. The majority of cancer cells in all of the 20 SNLECs showed EBV encoded early RNAs. The EBV nuclear antigen 1 expression of SNLEC was less intensive than that of NPC. The expression rate of latent membrane protein 1 for SNLEC (3/20, 15%) was lower than that for NPC (19/36, 52.8%). The expression rates of BZLF1 protein (2/20, 10.0%), diffuse early antigen (19/20, 95.0%), viral capsid antigen (15/20, 75.0%), and membrane antigen (13/20, 65.0%) for SNLEC were higher than those (0/36, 0.0%; 31/36, 86.0%; 18/36, 50%; and 14/36, 38.9%) for NPC.
SNLEC is not uncommon in Guangzhou. This tumour is also consistently associated with EBV infection like NPC. As compared to NPC, the EBV harbored in SNLECs seems to express the EBV nuclear antigen 1 weakly and has a lower expression rate of latent membrane protein 1 as well as higher expression rates of EBV lytic products.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - complications</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>China - epidemiology</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Female</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Paranasal Sinus Neoplasms - complications</subject><subject>Paranasal Sinus Neoplasms - epidemiology</subject><subject>Paranasal Sinus Neoplasms - pathology</subject><subject>Viral Proteins - analysis</subject><subject>Viral Proteins - genetics</subject><issn>0366-6999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KxDAAhHNQ3HX1FSQnb4U0_znqsq4LCyLouaRpaiNpEpNWWJ_egutpYOabOcwFWCPCecWVUitwXconQpgxwa_Aqq6FRLWq1-B1l8pkXagedc7w2-W5QBd6ayYXA4w9LC7EoIv20J_GNESb3DRY7xbD6GyWdNRLA-5nHT5-hjjfgMte-2Jvz7oB70-7t-1zdXzZH7YPxyphJKaqtUJRRDmlirecScKp1FIYLAXDqieC90giRTWl2lBDDDa95F1HMCUtY4hswP3fbsrxa7ZlakZXjPVeBxvn0ghMJFaIL-DdGZzb0XZNym7U-dT8n0B-AWVbV3g</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>Zong, Y</creator><creator>Liu, K</creator><creator>Zhong, B</creator><creator>Chen, G</creator><creator>Wu, W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200102</creationdate><title>Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou</title><author>Zong, Y ; Liu, K ; Zhong, B ; Chen, G ; Wu, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-be7940464496b6583648a87c287529f376f08094a44ac4c3c2cf86dd3243b5503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - complications</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>China - epidemiology</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Female</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Paranasal Sinus Neoplasms - complications</topic><topic>Paranasal Sinus Neoplasms - epidemiology</topic><topic>Paranasal Sinus Neoplasms - pathology</topic><topic>Viral Proteins - analysis</topic><topic>Viral Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zong, Y</creatorcontrib><creatorcontrib>Liu, K</creatorcontrib><creatorcontrib>Zhong, B</creatorcontrib><creatorcontrib>Chen, G</creatorcontrib><creatorcontrib>Wu, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zong, Y</au><au>Liu, K</au><au>Zhong, B</au><au>Chen, G</au><au>Wu, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chin Med J (Engl)</addtitle><date>2001-02</date><risdate>2001</risdate><volume>114</volume><issue>2</issue><spage>132</spage><epage>136</epage><pages>132-136</pages><issn>0366-6999</issn><abstract>To investigate the prevalence of sinonasal lymphoepithelial carcinoma (SNLEC) in Guangzhou, a high incidence area of nasopharyngeal carcinoma (NPC), and to detect whether it is associated with Epstein-Barr virus (EBV) infection.
Twenty confirmed SNLEC specimens were collected from all of the sinonasal carcinoma biopsies performed in the 8 years 1989-1996 at the Sun Yat-sen University of Medical Sciences. EBV encoded early RNAs were detected by use of in-situ hybridization. A variety of antigens, including the EBV nuclear antigen 1, latent membrane protein 1, BZLF1 protein, diffuse early antigen, viral capsid antigen and membrane antigen, were detected using immunohistochemistry. Additionally, 36 NPC specimens were used for comparison.
Twenty SNLECs were identified. Seventeen SNLECs were developed in the nasal cavity, and 3 in the maxillary sinus. The mean age (46.25 y), male to female ratio (3:1), histopathology and lymphoinfiltration of the 20 SNLECs were identical with those of the 36 NPCs. Thirteen (65.0%) of the 20 SNLECs showed an expansive growth pattern, while 27 (75.0%) of the 36 NPCs showed an infiltrating or mixed growth pattern. The majority of cancer cells in all of the 20 SNLECs showed EBV encoded early RNAs. The EBV nuclear antigen 1 expression of SNLEC was less intensive than that of NPC. The expression rate of latent membrane protein 1 for SNLEC (3/20, 15%) was lower than that for NPC (19/36, 52.8%). The expression rates of BZLF1 protein (2/20, 10.0%), diffuse early antigen (19/20, 95.0%), viral capsid antigen (15/20, 75.0%), and membrane antigen (13/20, 65.0%) for SNLEC were higher than those (0/36, 0.0%; 31/36, 86.0%; 18/36, 50%; and 14/36, 38.9%) for NPC.
SNLEC is not uncommon in Guangzhou. This tumour is also consistently associated with EBV infection like NPC. As compared to NPC, the EBV harbored in SNLECs seems to express the EBV nuclear antigen 1 weakly and has a lower expression rate of latent membrane protein 1 as well as higher expression rates of EBV lytic products.</abstract><cop>China</cop><pmid>11780191</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology China - epidemiology Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - virology Female Herpesvirus 4, Human - genetics Humans Immunohistochemistry In Situ Hybridization Male Middle Aged Paranasal Sinus Neoplasms - complications Paranasal Sinus Neoplasms - epidemiology Paranasal Sinus Neoplasms - pathology Viral Proteins - analysis Viral Proteins - genetics |
| title | Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou |
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