A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors
WT2 is defined by a maternal-specific loss of heterozygosity on human chromosome 11p15.5 in Wilms' and other embryonal tumors. Therefore, the imprinted genes in this region are candidates for involvement in Wilms' tumorigenesis. We now report a novel imprinted gene, KCNQ1DN (KCNQ1 downstre...
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| Veröffentlicht in: | Journal of biochemistry (Tokyo) 2000-11, Vol.128 (5), p.847-853 |
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| container_title | Journal of biochemistry (Tokyo) |
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| creator | Xin, Zhenghan Soejima, Hidenobu Higashimoto, Ken Yatsuki, Hitomi Zhu, Xike Satoh, Yuji Masaki, Zenjiro Kaneko, Yasuhiko Jinno, Yoshihiro Fukuzawa, Ryuji Hata, Jun-ichi Mukai, Tsunehiro |
| description | WT2 is defined by a maternal-specific loss of heterozygosity on human chromosome 11p15.5 in Wilms' and other embryonal tumors. Therefore, the imprinted genes in this region are candidates for involvement in Wilms' tumorigenesis. We now report a novel imprinted gene, KCNQ1DN (KCNQ1 downstream neighbor). This gene is located between p57KIP2 and KuLQT1 (KCNQ1) of 11p15.5 within the WT2 critical region. KCNQ1DN is imprinted and expressed from the maternal allele. We examined the expression of KCNQ1DN in Wilms' tumors. Seven of eighteen (39%) samples showed no expression. In contrast, other maternal imprinted genes in this region, including p57KIP2, IMPT1, and IPL exhibited almost normal expression in these samples, although some samples expressed IGF2 biallelically. These results suggest that KCNQ1DN existing far from the H19øIGF2 region may play some role in Wilms' tumorigenesis along with IGF2. |
| doi_str_mv | 10.1093/oxfordjournals.jbchem.a022823 |
| format | Article |
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Therefore, the imprinted genes in this region are candidates for involvement in Wilms' tumorigenesis. We now report a novel imprinted gene, KCNQ1DN (KCNQ1 downstream neighbor). This gene is located between p57KIP2 and KuLQT1 (KCNQ1) of 11p15.5 within the WT2 critical region. KCNQ1DN is imprinted and expressed from the maternal allele. We examined the expression of KCNQ1DN in Wilms' tumors. Seven of eighteen (39%) samples showed no expression. In contrast, other maternal imprinted genes in this region, including p57KIP2, IMPT1, and IPL exhibited almost normal expression in these samples, although some samples expressed IGF2 biallelically. These results suggest that KCNQ1DN existing far from the H19øIGF2 region may play some role in Wilms' tumorigenesis along with IGF2.</description><identifier>ISSN: 0021-924X</identifier><identifier>DOI: 10.1093/oxfordjournals.jbchem.a022823</identifier><identifier>PMID: 11056398</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Chromosome Mapping ; Chromosomes, Human, Pair 11 ; CpG island ; Female ; Gene Expression Regulation, Neoplastic ; Gene Library ; Genomic Imprinting ; Humans ; imprinted genes ; KCNQ Potassium Channels ; KCNQ1 Potassium Channel ; KCNQ1DN ; Loss of Heterozygosity ; Male ; Molecular Sequence Data ; Potassium Channels - genetics ; Potassium Channels, Voltage-Gated ; Testis - chemistry ; Wilms Tumor - genetics ; Wilms' tumors</subject><ispartof>Journal of biochemistry (Tokyo), 2000-11, Vol.128 (5), p.847-853</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-65892a465805611503d23c46c797bb834866e994b0c3fdccdaa3909b815f052e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11056398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xin, Zhenghan</creatorcontrib><creatorcontrib>Soejima, Hidenobu</creatorcontrib><creatorcontrib>Higashimoto, Ken</creatorcontrib><creatorcontrib>Yatsuki, Hitomi</creatorcontrib><creatorcontrib>Zhu, Xike</creatorcontrib><creatorcontrib>Satoh, Yuji</creatorcontrib><creatorcontrib>Masaki, Zenjiro</creatorcontrib><creatorcontrib>Kaneko, Yasuhiko</creatorcontrib><creatorcontrib>Jinno, Yoshihiro</creatorcontrib><creatorcontrib>Fukuzawa, Ryuji</creatorcontrib><creatorcontrib>Hata, Jun-ichi</creatorcontrib><creatorcontrib>Mukai, Tsunehiro</creatorcontrib><title>A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors</title><title>Journal of biochemistry (Tokyo)</title><addtitle>J Biochem</addtitle><description>WT2 is defined by a maternal-specific loss of heterozygosity on human chromosome 11p15.5 in Wilms' and other embryonal tumors. Therefore, the imprinted genes in this region are candidates for involvement in Wilms' tumorigenesis. We now report a novel imprinted gene, KCNQ1DN (KCNQ1 downstream neighbor). This gene is located between p57KIP2 and KuLQT1 (KCNQ1) of 11p15.5 within the WT2 critical region. KCNQ1DN is imprinted and expressed from the maternal allele. We examined the expression of KCNQ1DN in Wilms' tumors. Seven of eighteen (39%) samples showed no expression. In contrast, other maternal imprinted genes in this region, including p57KIP2, IMPT1, and IPL exhibited almost normal expression in these samples, although some samples expressed IGF2 biallelically. These results suggest that KCNQ1DN existing far from the H19øIGF2 region may play some role in Wilms' tumorigenesis along with IGF2.</description><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11</subject><subject>CpG island</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Library</subject><subject>Genomic Imprinting</subject><subject>Humans</subject><subject>imprinted genes</subject><subject>KCNQ Potassium Channels</subject><subject>KCNQ1 Potassium Channel</subject><subject>KCNQ1DN</subject><subject>Loss of Heterozygosity</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Potassium Channels - genetics</subject><subject>Potassium Channels, Voltage-Gated</subject><subject>Testis - chemistry</subject><subject>Wilms Tumor - genetics</subject><subject>Wilms' tumors</subject><issn>0021-924X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtuEzEUhr0A0VJ4BeQNsOkEX-biWbCopm0SEQWVBlJ1Y3k8Z4jDeBzsGQhPwGvjKBGI1dGRv_-3zofQa0omlJT8ndu3zjdbN_pedWGyrfUG7EQRxgTjT9A5IYwmJUsfztDzELaHlXH-DJ1RSrKcl-Ic_b7CS_cDOjy3O2_6ARo8hR4u8YdqeUevl5f4pxk2psfDBvB6xXDlzWC06vAn-Gpcj12LZ6NVPa423lkXnAVM6Y5mkwyrvsHzIUS0GXVsvtnvPIRwiMXGtelseItXo3U-vEBP23gDvDzNC_T59mZVzZLFx-m8ulokOhV0SPJMlEylccQDKM0IbxjXaa6LsqhrwVOR51CWaU00bxutG6V4Scpa0KwlGQN-gd4ce3fefR8hDNKaoKHrVA9uDLJgXDCR8wi-P4LauxA8tDL6scr_kpTIg335v315tC9P9mP-1emjsbbQ_Euf1EcgOQImDLD_-678N5kXvMjk7OFR3k9v1_eLL3fykf8Byl6YOQ</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Xin, Zhenghan</creator><creator>Soejima, Hidenobu</creator><creator>Higashimoto, Ken</creator><creator>Yatsuki, Hitomi</creator><creator>Zhu, Xike</creator><creator>Satoh, Yuji</creator><creator>Masaki, Zenjiro</creator><creator>Kaneko, Yasuhiko</creator><creator>Jinno, Yoshihiro</creator><creator>Fukuzawa, Ryuji</creator><creator>Hata, Jun-ichi</creator><creator>Mukai, Tsunehiro</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors</title><author>Xin, Zhenghan ; Soejima, Hidenobu ; Higashimoto, Ken ; Yatsuki, Hitomi ; Zhu, Xike ; Satoh, Yuji ; Masaki, Zenjiro ; Kaneko, Yasuhiko ; Jinno, Yoshihiro ; Fukuzawa, Ryuji ; Hata, Jun-ichi ; Mukai, Tsunehiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-65892a465805611503d23c46c797bb834866e994b0c3fdccdaa3909b815f052e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11</topic><topic>CpG island</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Library</topic><topic>Genomic Imprinting</topic><topic>Humans</topic><topic>imprinted genes</topic><topic>KCNQ Potassium Channels</topic><topic>KCNQ1 Potassium Channel</topic><topic>KCNQ1DN</topic><topic>Loss of Heterozygosity</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Potassium Channels - genetics</topic><topic>Potassium Channels, Voltage-Gated</topic><topic>Testis - chemistry</topic><topic>Wilms Tumor - genetics</topic><topic>Wilms' tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xin, Zhenghan</creatorcontrib><creatorcontrib>Soejima, Hidenobu</creatorcontrib><creatorcontrib>Higashimoto, Ken</creatorcontrib><creatorcontrib>Yatsuki, Hitomi</creatorcontrib><creatorcontrib>Zhu, Xike</creatorcontrib><creatorcontrib>Satoh, Yuji</creatorcontrib><creatorcontrib>Masaki, Zenjiro</creatorcontrib><creatorcontrib>Kaneko, Yasuhiko</creatorcontrib><creatorcontrib>Jinno, Yoshihiro</creatorcontrib><creatorcontrib>Fukuzawa, Ryuji</creatorcontrib><creatorcontrib>Hata, Jun-ichi</creatorcontrib><creatorcontrib>Mukai, Tsunehiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xin, Zhenghan</au><au>Soejima, Hidenobu</au><au>Higashimoto, Ken</au><au>Yatsuki, Hitomi</au><au>Zhu, Xike</au><au>Satoh, Yuji</au><au>Masaki, Zenjiro</au><au>Kaneko, Yasuhiko</au><au>Jinno, Yoshihiro</au><au>Fukuzawa, Ryuji</au><au>Hata, Jun-ichi</au><au>Mukai, Tsunehiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors</atitle><jtitle>Journal of biochemistry (Tokyo)</jtitle><addtitle>J Biochem</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>128</volume><issue>5</issue><spage>847</spage><epage>853</epage><pages>847-853</pages><issn>0021-924X</issn><abstract>WT2 is defined by a maternal-specific loss of heterozygosity on human chromosome 11p15.5 in Wilms' and other embryonal tumors. Therefore, the imprinted genes in this region are candidates for involvement in Wilms' tumorigenesis. We now report a novel imprinted gene, KCNQ1DN (KCNQ1 downstream neighbor). This gene is located between p57KIP2 and KuLQT1 (KCNQ1) of 11p15.5 within the WT2 critical region. KCNQ1DN is imprinted and expressed from the maternal allele. We examined the expression of KCNQ1DN in Wilms' tumors. Seven of eighteen (39%) samples showed no expression. In contrast, other maternal imprinted genes in this region, including p57KIP2, IMPT1, and IPL exhibited almost normal expression in these samples, although some samples expressed IGF2 biallelically. These results suggest that KCNQ1DN existing far from the H19øIGF2 region may play some role in Wilms' tumorigenesis along with IGF2.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>11056398</pmid><doi>10.1093/oxfordjournals.jbchem.a022823</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of biochemistry (Tokyo), 2000-11, Vol.128 (5), p.847-853 |
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| subjects | Chromosome Mapping Chromosomes, Human, Pair 11 CpG island Female Gene Expression Regulation, Neoplastic Gene Library Genomic Imprinting Humans imprinted genes KCNQ Potassium Channels KCNQ1 Potassium Channel KCNQ1DN Loss of Heterozygosity Male Molecular Sequence Data Potassium Channels - genetics Potassium Channels, Voltage-Gated Testis - chemistry Wilms Tumor - genetics Wilms' tumors |
| title | A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors |
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