Pattern of alloimmune response in second same donor allografts after induction of tolerance using CTLA4Ig

The pattern of allograft acceptance in the presence of costimulatory blockade is manifested by the sequential appearance of Th1 cells, followed by Th2 cells. The aim of this study was to examine whether this phenomenon repeats itself after second same donor allotransplantation, hoping to determine w...

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Veröffentlicht in:	Transplantation 2001-12, Vol.72 (12), p.1952-1956
Hauptverfasser:	OLTHOFF, Kim M, GELMAN, Andrew E, ZAMIR, Gideon A, DEBONERA, Fotini, KRASINKAS, Alyssa M, XIUDA SHEN, FENG GAO, SHAKED, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Antibody Formation Antigens, CD Antigens, Differentiation - pharmacology Biological and medical sciences CTLA-4 Antigen CTLA-4 protein Cytokines - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival Heart Transplantation - immunology Immunoconjugates Liver - metabolism Liver - pathology Liver Transplantation - immunology Myocardium - metabolism Myocardium - pathology Rats Rats, Inbred ACI Rats, Inbred BN Rats, Inbred Lew Reoperation RNA, Messenger - metabolism Tissue Donors Tissue, organ and graft immunology Transplantation Tolerance - drug effects Transplantation, Homologous
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