Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3', 5'-cyclic adenosine monophosphate is additive in HepG2 cells

Insulin-like growth factor-binding protein 1 (IGFBP-1) is important in regulating minute-to-minute IGF bioavailability in the circulation and is primarily an inhibitor of IGF action systemically and in most cellular systems. Understanding regulation of IGFBP-1 is, thus, important in understanding re...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2000-10, Vol.85 (10), p.3821-3827
Hauptverfasser:	SUGAWARA, Junichi, TAZUKE, Salli I, F-SUEN, Lii, POWELL, David R, KAPER, Fiona, GIACCIA, Amato J, GIUDICE, Linda C
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Analytical, structural and metabolic biochemistry Animals Binding and carrier proteins Biological and medical sciences Blotting, Northern Blotting, Western Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Half-Life Humans Hypoxia - metabolism Immunoradiometric Assay Insulin-Like Growth Factor Binding Protein 1 - biosynthesis Insulin-Like Growth Factor Binding Protein 1 - genetics Liver Neoplasms, Experimental - metabolism Proteins RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Tumor Cells, Cultured
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