Effect of weight loss on the pulsatile insulin secretion
The aim of the study was to assess whether pulsatile insulin secretion is variable in the same individual and is related to changes in insulin sensitivity. Insulin sensitivity and pulsatility were measured before and after weight reduction in nine obese subjects. A pulsatility analysis was done usin...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2000-10, Vol.85 (10), p.3673-3677 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | ZARKOVIC, Milos CIRIC, Jasmina PENEZIC, Zorana TRBOJEVIC, Bozo DREZGIC, Milka |
| description | The aim of the study was to assess whether pulsatile insulin secretion is variable in the same individual and is related to changes in insulin sensitivity. Insulin sensitivity and pulsatility were measured before and after weight reduction in nine obese subjects. A pulsatility analysis was done using the PulsDetekt program. Blood was sampled every 2 min over a period of 90 min. The secretion randomness was quantified using approximate entropy (ApEn), and ApEn normalized by SD of the insulin time series (nApEn). Lower values indicate more regular secretion. Insulin sensitivity was measured using the homeostasis model assessment. Data are presented as median, minimum-maximum. After weight loss insulin sensitivity was increased (12.16, 7.60-76.70 vs. 38.96, 19.88-74.96%), the number of insulin pulses was reduced (11, 8-16 vs. 9,6-12), and they were more regular (ApEn, 0.92, 0.53-133 vs. 0.69,0,40-1.27; nApEn, 1.07, 0.74-1.33 vs. 0.97, 0.54-1.42). Before and after the weight loss there was a correlation between ApEn and nApEn and insulin sensitivity. Therefore, insulin secretion regularity is variable in the same individual and is related to insulin sensitivity. |
| doi_str_mv | 10.1210/jc.85.10.3673 |
| format | Article |
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Insulin sensitivity and pulsatility were measured before and after weight reduction in nine obese subjects. A pulsatility analysis was done using the PulsDetekt program. Blood was sampled every 2 min over a period of 90 min. The secretion randomness was quantified using approximate entropy (ApEn), and ApEn normalized by SD of the insulin time series (nApEn). Lower values indicate more regular secretion. Insulin sensitivity was measured using the homeostasis model assessment. Data are presented as median, minimum-maximum. After weight loss insulin sensitivity was increased (12.16, 7.60-76.70 vs. 38.96, 19.88-74.96%), the number of insulin pulses was reduced (11, 8-16 vs. 9,6-12), and they were more regular (ApEn, 0.92, 0.53-133 vs. 0.69,0,40-1.27; nApEn, 1.07, 0.74-1.33 vs. 0.97, 0.54-1.42). Before and after the weight loss there was a correlation between ApEn and nApEn and insulin sensitivity. Therefore, insulin secretion regularity is variable in the same individual and is related to insulin sensitivity.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.85.10.3673</identifier><identifier>PMID: 11061521</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Biological and medical sciences ; Diet, Reducing ; Glucose Tolerance Test ; Homeostasis - physiology ; Humans ; Insulin - metabolism ; Insulin Resistance ; Kidney Function Tests ; Liver Function Tests ; Male ; Medical sciences ; Metabolic diseases ; Obesity ; Weight Loss - physiology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2000-10, Vol.85 (10), p.3673-3677</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1651-1ee8731213ecad8e58edb658aa30af8fe6c5675398e9ef8df3ac6b647d2760b93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1526885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11061521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZARKOVIC, Milos</creatorcontrib><creatorcontrib>CIRIC, Jasmina</creatorcontrib><creatorcontrib>PENEZIC, Zorana</creatorcontrib><creatorcontrib>TRBOJEVIC, Bozo</creatorcontrib><creatorcontrib>DREZGIC, Milka</creatorcontrib><title>Effect of weight loss on the pulsatile insulin secretion</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>The aim of the study was to assess whether pulsatile insulin secretion is variable in the same individual and is related to changes in insulin sensitivity. Insulin sensitivity and pulsatility were measured before and after weight reduction in nine obese subjects. A pulsatility analysis was done using the PulsDetekt program. Blood was sampled every 2 min over a period of 90 min. The secretion randomness was quantified using approximate entropy (ApEn), and ApEn normalized by SD of the insulin time series (nApEn). Lower values indicate more regular secretion. Insulin sensitivity was measured using the homeostasis model assessment. Data are presented as median, minimum-maximum. After weight loss insulin sensitivity was increased (12.16, 7.60-76.70 vs. 38.96, 19.88-74.96%), the number of insulin pulses was reduced (11, 8-16 vs. 9,6-12), and they were more regular (ApEn, 0.92, 0.53-133 vs. 0.69,0,40-1.27; nApEn, 1.07, 0.74-1.33 vs. 0.97, 0.54-1.42). Before and after the weight loss there was a correlation between ApEn and nApEn and insulin sensitivity. Therefore, insulin secretion regularity is variable in the same individual and is related to insulin sensitivity.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Diet, Reducing</subject><subject>Glucose Tolerance Test</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Kidney Function Tests</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Weight Loss - physiology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK0evcoexFviTjb7kaOU-gEFLwrewmYza7dsk5pNEP-9KQ30NLzwzMvMQ8gtsBQyYI9bm2qRjolLxc_IHIpcJAoKdU7mjGWQFCr7mpGrGLeMQZ4LfklmAEyCyGBO9Mo5tD1tHf1F_73paWhjpG1D-w3S_RCi6X1A6ps4BN_QiLbD3rfNNblwJkS8meaCfD6vPpavyfr95W35tE4sSAEJIGrFx0s5WlNrFBrrSgptDGfGaYfSCqkELzQW6HTtuLGykrmqMyVZVfAFeTj27rv2Z8DYlzsfLYZgGmyHWKqMaxjXRzA5grYbP-jQlfvO70z3VwIrD6rKrS21OKSDqpG_m4qHaof1iZ7cjMD9BJhoTXCdaayPJ05kUmvB_wHLkXCS</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>ZARKOVIC, Milos</creator><creator>CIRIC, Jasmina</creator><creator>PENEZIC, Zorana</creator><creator>TRBOJEVIC, Bozo</creator><creator>DREZGIC, Milka</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>Effect of weight loss on the pulsatile insulin secretion</title><author>ZARKOVIC, Milos ; CIRIC, Jasmina ; PENEZIC, Zorana ; TRBOJEVIC, Bozo ; DREZGIC, Milka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1651-1ee8731213ecad8e58edb658aa30af8fe6c5675398e9ef8df3ac6b647d2760b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Diet, Reducing</topic><topic>Glucose Tolerance Test</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Kidney Function Tests</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZARKOVIC, Milos</creatorcontrib><creatorcontrib>CIRIC, Jasmina</creatorcontrib><creatorcontrib>PENEZIC, Zorana</creatorcontrib><creatorcontrib>TRBOJEVIC, Bozo</creatorcontrib><creatorcontrib>DREZGIC, Milka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZARKOVIC, Milos</au><au>CIRIC, Jasmina</au><au>PENEZIC, Zorana</au><au>TRBOJEVIC, Bozo</au><au>DREZGIC, Milka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of weight loss on the pulsatile insulin secretion</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2000-10</date><risdate>2000</risdate><volume>85</volume><issue>10</issue><spage>3673</spage><epage>3677</epage><pages>3673-3677</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>The aim of the study was to assess whether pulsatile insulin secretion is variable in the same individual and is related to changes in insulin sensitivity. Insulin sensitivity and pulsatility were measured before and after weight reduction in nine obese subjects. A pulsatility analysis was done using the PulsDetekt program. Blood was sampled every 2 min over a period of 90 min. The secretion randomness was quantified using approximate entropy (ApEn), and ApEn normalized by SD of the insulin time series (nApEn). Lower values indicate more regular secretion. Insulin sensitivity was measured using the homeostasis model assessment. Data are presented as median, minimum-maximum. After weight loss insulin sensitivity was increased (12.16, 7.60-76.70 vs. 38.96, 19.88-74.96%), the number of insulin pulses was reduced (11, 8-16 vs. 9,6-12), and they were more regular (ApEn, 0.92, 0.53-133 vs. 0.69,0,40-1.27; nApEn, 1.07, 0.74-1.33 vs. 0.97, 0.54-1.42). Before and after the weight loss there was a correlation between ApEn and nApEn and insulin sensitivity. Therefore, insulin secretion regularity is variable in the same individual and is related to insulin sensitivity.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>11061521</pmid><doi>10.1210/jc.85.10.3673</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Biological and medical sciences Diet, Reducing Glucose Tolerance Test Homeostasis - physiology Humans Insulin - metabolism Insulin Resistance Kidney Function Tests Liver Function Tests Male Medical sciences Metabolic diseases Obesity Weight Loss - physiology |
| title | Effect of weight loss on the pulsatile insulin secretion |
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