Oestrogen receptor expression in normal breast epithelium
Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be...
Gespeichert in:
| Veröffentlicht in: | European journal of cancer (1990) 2000-09, Vol.36, p.27-28 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 28 |
|---|---|
| container_issue | |
| container_start_page | 27 |
| container_title | European journal of cancer (1990) |
| container_volume | 36 |
| creator | Khan, S.A Rogers, M.A.M Khurana, K.K Siddiqui, J.F.M |
| description | Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be more feasible on paraffin-embedded samples, and newer, more sensitive antibodies are now available. We examined 30 samples of paraffin-embedded breast epithelium from postmenopausal women with two antibodies, 6F11 and TE111. We find that the median labelling indices for ER are significantly higher using these antibodies, compared with previous results. The threshold for ER positivity will, therefore, have to be reset in future studies, since there are still many issues that remain to be resolved in this area. |
| doi_str_mv | 10.1016/S0959-8049(00)00211-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72380913</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959804900002112</els_id><sourcerecordid>72380913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-bc15d6db8c73245925579c50b0c711a1c4a07506a6b7dd001d6637a8c5590b283</originalsourceid><addsrcrecordid>eNqFkLtOxDAQRS0EYpfHJ4BSISgCYyeO4wqhFS9ppS2A2nLsWTBK4mAnCP6e7ENQUk1z7tyZQ8gJhUsKtLh6AsllWkIuzwEuABilKdshU1oKmULJ2S6Z_iITchDjOwCIMod9MqEUeJFBPiVygbEP_hXbJKDBrvchwa8uYIzOt4lrk9aHRtdJFVDHPsHO9W9Yu6E5IntLXUc83s5D8nJ3-zx7SOeL-8fZzTw1WUH7tDKU28JWpREZy7lknAtpOFRgBKWamlyD4FDoohLWAlBbFJnQpeFcQsXK7JCcbfZ2wX8M47WqcdFgXesW_RCVYFkJkmYjyDegCT7GgEvVBdfo8K0oqJUztXamVkIUgFo7U2zMnW4LhqpB-5faShqB6w2A45ufDoOKxmFr0LrRWa-sd_9U_AAjBHqZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72380913</pqid></control><display><type>article</type><title>Oestrogen receptor expression in normal breast epithelium</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Khan, S.A ; Rogers, M.A.M ; Khurana, K.K ; Siddiqui, J.F.M</creator><creatorcontrib>Khan, S.A ; Rogers, M.A.M ; Khurana, K.K ; Siddiqui, J.F.M</creatorcontrib><description>Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be more feasible on paraffin-embedded samples, and newer, more sensitive antibodies are now available. We examined 30 samples of paraffin-embedded breast epithelium from postmenopausal women with two antibodies, 6F11 and TE111. We find that the median labelling indices for ER are significantly higher using these antibodies, compared with previous results. The threshold for ER positivity will, therefore, have to be reset in future studies, since there are still many issues that remain to be resolved in this area.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/S0959-8049(00)00211-2</identifier><identifier>PMID: 11056304</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Breast - chemistry ; Breast cancer risk ; Epithelium - chemistry ; Female ; Humans ; Middle Aged ; Normal breast ; Oestrogen receptor ; Receptors, Estrogen - analysis</subject><ispartof>European journal of cancer (1990), 2000-09, Vol.36, p.27-28</ispartof><rights>2000 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-bc15d6db8c73245925579c50b0c711a1c4a07506a6b7dd001d6637a8c5590b283</citedby><cites>FETCH-LOGICAL-c361t-bc15d6db8c73245925579c50b0c711a1c4a07506a6b7dd001d6637a8c5590b283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0959-8049(00)00211-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11056304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, S.A</creatorcontrib><creatorcontrib>Rogers, M.A.M</creatorcontrib><creatorcontrib>Khurana, K.K</creatorcontrib><creatorcontrib>Siddiqui, J.F.M</creatorcontrib><title>Oestrogen receptor expression in normal breast epithelium</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be more feasible on paraffin-embedded samples, and newer, more sensitive antibodies are now available. We examined 30 samples of paraffin-embedded breast epithelium from postmenopausal women with two antibodies, 6F11 and TE111. We find that the median labelling indices for ER are significantly higher using these antibodies, compared with previous results. The threshold for ER positivity will, therefore, have to be reset in future studies, since there are still many issues that remain to be resolved in this area.</description><subject>Breast - chemistry</subject><subject>Breast cancer risk</subject><subject>Epithelium - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Normal breast</subject><subject>Oestrogen receptor</subject><subject>Receptors, Estrogen - analysis</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOxDAQRS0EYpfHJ4BSISgCYyeO4wqhFS9ppS2A2nLsWTBK4mAnCP6e7ENQUk1z7tyZQ8gJhUsKtLh6AsllWkIuzwEuABilKdshU1oKmULJ2S6Z_iITchDjOwCIMod9MqEUeJFBPiVygbEP_hXbJKDBrvchwa8uYIzOt4lrk9aHRtdJFVDHPsHO9W9Yu6E5IntLXUc83s5D8nJ3-zx7SOeL-8fZzTw1WUH7tDKU28JWpREZy7lknAtpOFRgBKWamlyD4FDoohLWAlBbFJnQpeFcQsXK7JCcbfZ2wX8M47WqcdFgXesW_RCVYFkJkmYjyDegCT7GgEvVBdfo8K0oqJUztXamVkIUgFo7U2zMnW4LhqpB-5faShqB6w2A45ufDoOKxmFr0LrRWa-sd_9U_AAjBHqZ</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Khan, S.A</creator><creator>Rogers, M.A.M</creator><creator>Khurana, K.K</creator><creator>Siddiqui, J.F.M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Oestrogen receptor expression in normal breast epithelium</title><author>Khan, S.A ; Rogers, M.A.M ; Khurana, K.K ; Siddiqui, J.F.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-bc15d6db8c73245925579c50b0c711a1c4a07506a6b7dd001d6637a8c5590b283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Breast - chemistry</topic><topic>Breast cancer risk</topic><topic>Epithelium - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Normal breast</topic><topic>Oestrogen receptor</topic><topic>Receptors, Estrogen - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, S.A</creatorcontrib><creatorcontrib>Rogers, M.A.M</creatorcontrib><creatorcontrib>Khurana, K.K</creatorcontrib><creatorcontrib>Siddiqui, J.F.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, S.A</au><au>Rogers, M.A.M</au><au>Khurana, K.K</au><au>Siddiqui, J.F.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oestrogen receptor expression in normal breast epithelium</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>36</volume><spage>27</spage><epage>28</epage><pages>27-28</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be more feasible on paraffin-embedded samples, and newer, more sensitive antibodies are now available. We examined 30 samples of paraffin-embedded breast epithelium from postmenopausal women with two antibodies, 6F11 and TE111. We find that the median labelling indices for ER are significantly higher using these antibodies, compared with previous results. The threshold for ER positivity will, therefore, have to be reset in future studies, since there are still many issues that remain to be resolved in this area.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11056304</pmid><doi>10.1016/S0959-8049(00)00211-2</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 2000-09, Vol.36, p.27-28 |
| issn | 0959-8049 1879-0852 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72380913 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Breast - chemistry Breast cancer risk Epithelium - chemistry Female Humans Middle Aged Normal breast Oestrogen receptor Receptors, Estrogen - analysis |
| title | Oestrogen receptor expression in normal breast epithelium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T09%3A29%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oestrogen%20receptor%20expression%20in%20normal%20breast%20epithelium&rft.jtitle=European%20journal%20of%20cancer%20(1990)&rft.au=Khan,%20S.A&rft.date=2000-09-01&rft.volume=36&rft.spage=27&rft.epage=28&rft.pages=27-28&rft.issn=0959-8049&rft.eissn=1879-0852&rft_id=info:doi/10.1016/S0959-8049(00)00211-2&rft_dat=%3Cproquest_cross%3E72380913%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72380913&rft_id=info:pmid/11056304&rft_els_id=S0959804900002112&rfr_iscdi=true |