Uveitopathogenic Site of the γ-Subunit of Cyclic Guanosine Monophosphate Phosphodiesterase in Lewis Rats

Purpose: The γ-subunit of cyclic guanosine monophosphate phosphodiesterase (PDEγ) plays an important role in the phototransduction process of rod photoreceptors. A previous report indicated that experimental autoimmune uveoretinitis (EAU) could be induced in Lewis rats by immunization with PDEγ. In...

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Veröffentlicht in:	Japanese journal of ophthalmology 2001-11, Vol.45 (6), p.570-576
Hauptverfasser:	Matsunaga, Mutsumi, Abe, Tohru, Satoh, Naoki, Nakajima, Ako, Ohkoshi, Masatoshi, Sakuragi, Shozo
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - chemistry 3',5'-Cyclic-GMP Phosphodiesterases - immunology Amino Acid Sequence Animals Antibody Formation - immunology Autoantibodies - analysis Autoantigens - immunology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Cyclic Nucleotide Phosphodiesterases, Type 6 Enzyme-Linked Immunosorbent Assay Experimental autoimmune uveoretinitis Female Immunity, Cellular - immunology Immunization Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Lewis rat Molecular Sequence Data Oligopeptides - immunology Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - immunology Rats Rats, Inbred Lew Retinitis - immunology Retinitis - pathology Rod Cell Outer Segment - immunology Rod Cell Outer Segment - pathology synthetic peptides Uveitis - immunology Uveitis - pathology uveitopathogenic site γ-subunit of cyclic guanosine monophosphate phosphodiesterase
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