Synaptosomes still viable after 25 years of superfusion
Superfused synaptosomes have been utilized in studies of neurotransmitter release during 25 years. This review summarizes the aspects of neurotransmission that have been and could be successfully investigated with this technique. The major aim of the article is to draw attention on the versatility o...
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| Veröffentlicht in: | Neurochemical research 2000-10, Vol.25 (9-10), p.1265-1274 |
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| container_title | Neurochemical research |
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| creator | RAITERI, Luca RAITERI, Maurizio |
| description | Superfused synaptosomes have been utilized in studies of neurotransmitter release during 25 years. This review summarizes the aspects of neurotransmission that have been and could be successfully investigated with this technique. The major aim of the article is to draw attention on the versatility of superfused synaptosomes and to suggest how the system could be exploited in clarifying several aspects of synaptic neurochemistry including neurotransmitter transport, receptor localization, receptor-receptor interactions, functional aspects of multi-sited receptor complexes, receptor heterogeneity and mechanisms of neurotransmitter exocytosis-endocytosis. |
| doi_str_mv | 10.1023/A:1007648229795 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 2000-10, Vol.25 (9-10), p.1265-1274 |
| issn | 0364-3190 1573-6903 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biological and medical sciences Endocytosis Exocytosis Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Neurotransmitter Agents - metabolism Perfusion - instrumentation Perfusion - methods Synapses - physiology Synaptic Transmission - physiology Synaptosomes - physiology Vertebrates: nervous system and sense organs |
| title | Synaptosomes still viable after 25 years of superfusion |
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