CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation

CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind s...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2001-12, Vol.15 (6), p.1051-1061
Hauptverfasser:	Daniels, Mark A., Devine, Lesley, Miller, Joseph D., Moser, Janice M., Lukacher, Aron E., Altman, John D., Kavathas, Paula, Hogquist, Kristin A., Jameson, Stephen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Sub-Family B Member 2 ATP-Binding Cassette Transporters - genetics CD3 Complex - metabolism CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8 Antigens - immunology CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Adhesion Cell Differentiation Cellular Senescence Glycosylation H-2 Antigens - immunology H-2 Antigens - metabolism Histocompatibility Antigen H-2D Ligands Macromolecular Substances Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout N-Acetylneuraminic Acid - metabolism Neuraminidase - pharmacology Ovalbumin - immunology Peptide Fragments - immunology Protein Binding Protein Processing, Post-Translational Receptors, Antigen, T-Cell, alpha-beta - deficiency Receptors, Antigen, T-Cell, alpha-beta - genetics Rheology Solubility T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymus Gland - cytology Thymus Gland - growth & development
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