CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation
CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind s...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2001-12, Vol.15 (6), p.1051-1061 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Daniels, Mark A. Devine, Lesley Miller, Joseph D. Moser, Janice M. Lukacher, Aron E. Altman, John D. Kavathas, Paula Hogquist, Kristin A. Jameson, Stephen C. |
| description | CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8
+ T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state. |
| doi_str_mv | 10.1016/S1074-7613(01)00252-7 |
| format | Article |
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+ T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/S1074-7613(01)00252-7</identifier><identifier>PMID: 11754824</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; ATP-Binding Cassette Sub-Family B Member 2 ; ATP-Binding Cassette Transporters - genetics ; CD3 Complex - metabolism ; CD4-Positive T-Lymphocytes - cytology ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - metabolism ; CD8 antigen ; CD8 Antigens - immunology ; CD8 Antigens - metabolism ; CD8-Positive T-Lymphocytes - cytology ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Cell Adhesion ; Cell Differentiation ; Cellular Senescence ; Glycosylation ; H-2 Antigens - immunology ; H-2 Antigens - metabolism ; Histocompatibility Antigen H-2D ; Ligands ; Macromolecular Substances ; Membrane Glycoproteins - metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; N-Acetylneuraminic Acid - metabolism ; Neuraminidase - pharmacology ; Ovalbumin - immunology ; Peptide Fragments - immunology ; Protein Binding ; Protein Processing, Post-Translational ; Receptors, Antigen, T-Cell, alpha-beta - deficiency ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Rheology ; Solubility ; T-Lymphocyte Subsets - cytology ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; Thymus Gland - cytology ; Thymus Gland - growth & development</subject><ispartof>Immunity (Cambridge, Mass.), 2001-12, Vol.15 (6), p.1051-1061</ispartof><rights>2001 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4067-47c68a823b468334fc43bfcc31b0a1f55e9c2ad09b0d3d6b72a528ad72dc83c93</citedby><cites>FETCH-LOGICAL-c4067-47c68a823b468334fc43bfcc31b0a1f55e9c2ad09b0d3d6b72a528ad72dc83c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1074-7613(01)00252-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11754824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daniels, Mark A.</creatorcontrib><creatorcontrib>Devine, Lesley</creatorcontrib><creatorcontrib>Miller, Joseph D.</creatorcontrib><creatorcontrib>Moser, Janice M.</creatorcontrib><creatorcontrib>Lukacher, Aron E.</creatorcontrib><creatorcontrib>Altman, John D.</creatorcontrib><creatorcontrib>Kavathas, Paula</creatorcontrib><creatorcontrib>Hogquist, Kristin A.</creatorcontrib><creatorcontrib>Jameson, Stephen C.</creatorcontrib><title>CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8
+ T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state.</description><subject>Animals</subject><subject>ATP-Binding Cassette Sub-Family B Member 2</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>CD3 Complex - metabolism</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD8 antigen</subject><subject>CD8 Antigens - immunology</subject><subject>CD8 Antigens - metabolism</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Cell Adhesion</subject><subject>Cell Differentiation</subject><subject>Cellular Senescence</subject><subject>Glycosylation</subject><subject>H-2 Antigens - immunology</subject><subject>H-2 Antigens - metabolism</subject><subject>Histocompatibility Antigen H-2D</subject><subject>Ligands</subject><subject>Macromolecular Substances</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>N-Acetylneuraminic Acid - metabolism</subject><subject>Neuraminidase - pharmacology</subject><subject>Ovalbumin - immunology</subject><subject>Peptide Fragments - immunology</subject><subject>Protein Binding</subject><subject>Protein Processing, Post-Translational</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - deficiency</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Rheology</subject><subject>Solubility</subject><subject>T-Lymphocyte Subsets - cytology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - growth & development</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVp6G7S_oQGnUpycDIjyZZ8Cq3zhCw5ZHPoSciSXBS09sayA_vv631AjoGBGYZvHnyE_ES4QMDi8hlBikwWyM8AzwFYzjL5hcwRSpkJVPB1Wx-QGTlO6RUARV7CNzJDlLlQTMzJ3-pa0T-hdaH9R4eOLu4rWkWTEn2giy56O0Y_1VO0TRx9a72j9YYuaeVjpAszjL0ZQtdS0zp6Fze2S5u463wnR42Jyf845BPycnuzrO6zx6e7h-r3Y2YFFNOr0hbKKMZrUSjORWMFrxtrOdZgsMlzX1pmHJQ1OO6KWjKTM2WcZM4qbkt-Qn7t96777m30adCrkOz0nWl9NyYtGZcl5-xTENXkUKCcwHwP2r5LqfeNXvdhZfqNRtBb-XonX2_NakC9k6-3c6eHA2O98u5j6mB7Aq72gJ98vAff62TDzmnovR2068InJ_4Dsz6RtQ</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Daniels, Mark A.</creator><creator>Devine, Lesley</creator><creator>Miller, Joseph D.</creator><creator>Moser, Janice M.</creator><creator>Lukacher, Aron E.</creator><creator>Altman, John D.</creator><creator>Kavathas, Paula</creator><creator>Hogquist, Kristin A.</creator><creator>Jameson, Stephen C.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200112</creationdate><title>CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation</title><author>Daniels, Mark A. ; Devine, Lesley ; Miller, Joseph D. ; Moser, Janice M. ; Lukacher, Aron E. ; Altman, John D. ; Kavathas, Paula ; Hogquist, Kristin A. ; Jameson, Stephen C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4067-47c68a823b468334fc43bfcc31b0a1f55e9c2ad09b0d3d6b72a528ad72dc83c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>ATP-Binding Cassette Sub-Family B Member 2</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>CD3 Complex - metabolism</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>CD8 antigen</topic><topic>CD8 Antigens - immunology</topic><topic>CD8 Antigens - metabolism</topic><topic>CD8-Positive T-Lymphocytes - cytology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Cell Adhesion</topic><topic>Cell Differentiation</topic><topic>Cellular Senescence</topic><topic>Glycosylation</topic><topic>H-2 Antigens - immunology</topic><topic>H-2 Antigens - metabolism</topic><topic>Histocompatibility Antigen H-2D</topic><topic>Ligands</topic><topic>Macromolecular Substances</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>N-Acetylneuraminic Acid - metabolism</topic><topic>Neuraminidase - pharmacology</topic><topic>Ovalbumin - immunology</topic><topic>Peptide Fragments - immunology</topic><topic>Protein Binding</topic><topic>Protein Processing, Post-Translational</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - deficiency</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Rheology</topic><topic>Solubility</topic><topic>T-Lymphocyte Subsets - cytology</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daniels, Mark A.</creatorcontrib><creatorcontrib>Devine, Lesley</creatorcontrib><creatorcontrib>Miller, Joseph D.</creatorcontrib><creatorcontrib>Moser, Janice M.</creatorcontrib><creatorcontrib>Lukacher, Aron E.</creatorcontrib><creatorcontrib>Altman, John D.</creatorcontrib><creatorcontrib>Kavathas, Paula</creatorcontrib><creatorcontrib>Hogquist, Kristin A.</creatorcontrib><creatorcontrib>Jameson, Stephen C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daniels, Mark A.</au><au>Devine, Lesley</au><au>Miller, Joseph D.</au><au>Moser, Janice M.</au><au>Lukacher, Aron E.</au><au>Altman, John D.</au><au>Kavathas, Paula</au><au>Hogquist, Kristin A.</au><au>Jameson, Stephen C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2001-12</date><risdate>2001</risdate><volume>15</volume><issue>6</issue><spage>1051</spage><epage>1061</epage><pages>1051-1061</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8
+ T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11754824</pmid><doi>10.1016/S1074-7613(01)00252-7</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1074-7613 |
| ispartof | Immunity (Cambridge, Mass.), 2001-12, Vol.15 (6), p.1051-1061 |
| issn | 1074-7613 1097-4180 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals ATP-Binding Cassette Sub-Family B Member 2 ATP-Binding Cassette Transporters - genetics CD3 Complex - metabolism CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8 Antigens - immunology CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Adhesion Cell Differentiation Cellular Senescence Glycosylation H-2 Antigens - immunology H-2 Antigens - metabolism Histocompatibility Antigen H-2D Ligands Macromolecular Substances Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout N-Acetylneuraminic Acid - metabolism Neuraminidase - pharmacology Ovalbumin - immunology Peptide Fragments - immunology Protein Binding Protein Processing, Post-Translational Receptors, Antigen, T-Cell, alpha-beta - deficiency Receptors, Antigen, T-Cell, alpha-beta - genetics Rheology Solubility T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymus Gland - cytology Thymus Gland - growth & development |
| title | CD8 Binding to MHC Class I Molecules Is Influenced by T Cell Maturation and Glycosylation |
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