Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

Signal transducers and activators of transcription (STATs) are transcription factors activated in response to cytokines and growth factors. Constitutively active Stat3 has been shown to mediate oncogenic transformation in cultured cells and induce tumor formation in mice. An increasing number of tum...

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Veröffentlicht in:	Oncogene 2001-11, Vol.20 (55), p.7925-7934
Hauptverfasser:	BURKE, William M, XIAOHONG JIN, LIN, Huey-Jen, HUANG, Melinda, LIU, Rebecca, REYNOLDS, R. Kevin, JIAYUH LIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Bcl-x protein Biological and medical sciences Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell cycle Cell Division - drug effects Cell growth Cell Line Cell Size - drug effects Chemotherapy Cisplatin Cisplatin - pharmacology Cytokines DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Electrophoretic Mobility Shift Assay Enzyme inhibitors Epithelial Cells - metabolism Epithelial Cells - pathology Female Fibroblasts - metabolism Fibroblasts - pathology Fundamental and applied biological sciences. Psychology Genes, Dominant Growth factors Humans Janus kinase Janus Kinase 3 Kinases Molecular and cellular biology Mutation - genetics Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation Phosphorylation - drug effects Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Signal transduction Signal Transduction - drug effects Stat3 protein STAT3 Transcription Factor Time Factors Trans-Activators - antagonists & inhibitors Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Transfection Tumor cell lines Tumor Cells, Cultured Tyrphostins - pharmacology
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