Analysis of the murine phosphoinositide 3-kinase γ gene

Phosphoinositide 3-kinase γ is preferentially expressed in leukocytes. PI3Kγ is activated by βγ subunits of heterotrimeric G-proteins, which thus link seven transmembrane helix receptor activation to phosphatidylinositol (3,4,5)-trisphosphate production. Here we describe the molecular cloning of the...

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Veröffentlicht in:	Gene 2000-10, Vol.256 (1), p.69-81
Hauptverfasser:	Hirsch, Emilio, Wymann, Matthias P., Patrucco, Enrico, Tolosano, Emanuela, Bulgarelli-Leva, Ginette, Marengo, Stefano, Rocchi, Mariano, Altruda, Fiorella
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Chromosomal localization chromosome 12 chromosome 7 Chromosome Mapping Chromosomes - genetics Chromosomes, Human, Pair 7 - genetics Class Ib Phosphatidylinositol 3-Kinase Cloning, Molecular DNA - chemistry DNA - genetics DNA, Complementary - chemistry DNA, Complementary - genetics Exons G protein-coupled receptors Gene structure Genes - genetics HeLa Cells Humans In Situ Hybridization, Fluorescence Introns Isoenzymes - genetics Isoenzymes - metabolism Luciferases - genetics Luciferases - metabolism Mice Mice, Inbred Strains Molecular Sequence Data phosphatidylinositol (3,4,5)-trisphosphate Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide 3-kinase ^g PI3K PI3K^g gene PI3Kg gene Promoter Promoter Regions, Genetic - genetics Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Alignment Sequence Analysis, DNA Sequence Deletion Sequence Homology, Amino Acid Transcription, Genetic U937 Cells Wortmannin
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