D-amphetamine does not improve outcome of somatosensory training
D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke. To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have con...
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| Veröffentlicht in: | Neurology 2001-12, Vol.57 (12), p.2248-2252 |
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| container_end_page | 2252 |
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| container_issue | 12 |
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| container_title | Neurology |
| container_volume | 57 |
| creator | KNECHT, S IMAI, T KAMPING, S BREITENSTEIN, C HENNINGSEN, H LÜTKENHÖNER, B RINGELSTEIN, E. B |
| description | D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke.
To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.
Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.
All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.
No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects. |
| doi_str_mv | 10.1212/WNL.57.12.2248 |
| format | Article |
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To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.
Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.
All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.
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To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.
Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.
All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.
No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Dextroamphetamine - administration & dosage</subject><subject>Discrimination Learning - drug effects</subject><subject>Discrimination Learning - physiology</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Stimulation</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.
Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.
All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.
No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11756605</pmid><doi>10.1212/WNL.57.12.2248</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurology, 2001-12, Vol.57 (12), p.2248-2252 |
| issn | 0028-3878 1526-632X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72378151 |
| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Analysis of Variance Biological and medical sciences Dextroamphetamine - administration & dosage Discrimination Learning - drug effects Discrimination Learning - physiology Double-Blind Method Drug Administration Schedule Humans Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Physical Stimulation Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Stroke - drug therapy Stroke - physiopathology |
| title | D-amphetamine does not improve outcome of somatosensory training |
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