Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta

Gene transfer to the vessel wall may provide new possibilities for the treatment of vascular disorders, such as postangioplasty restenosis. In this study, we analyzed the effects of adenovirus-mediated vascular endothelial growth factor (VEGF)-C gene transfer on neointima formation after endothelial...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-10, Vol.102 (18), p.2262-2268
Hauptverfasser:	HILTUNEN, Mikko O, LAITINEN, Marja, KIVELÄ, Antti, ENHOLM, Berndt, MANSUKOSKI, Hannu, TURUNEN, Anna-Mari, ALITALO, Kari, YLÄ-HERTTUALA, Seppo, TURUNEN, Mikko P, JELTSCH, Michael, HARTIKAINEN, Juha, RISSANEN, Tuomas T, LAUKKANEN, Johanna, NIEMI, Man, KOSSILA, Maija, HÄKKINEN, Tomi P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Angioplasty, Balloon - adverse effects Animals Aortic Valve Stenosis - etiology Aortic Valve Stenosis - metabolism Aortic Valve Stenosis - prevention & control Biological and medical sciences Cell Division - drug effects Cells, Cultured Diseases of the cardiovascular system Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - genetics Endothelial Growth Factors - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gene Transfer Techniques Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Proto-Oncogene Proteins - biosynthesis Rabbits Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Receptor Protein-Tyrosine Kinases - biosynthesis Receptors, Cell Surface - biosynthesis Receptors, Growth Factor - biosynthesis Receptors, Vascular Endothelial Growth Factor Transfection Tunica Intima - drug effects Tunica Intima - metabolism Tunica Intima - pathology Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-3
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