The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation
Background/Aim: The impact of liver disease and medical complications on quality of life (QOL) and psychological distress before and after orthotopic liver transplantation (OLT) is a matter of growing interest. Methods: Perceived QOL (LEIPAD Quality of Life test) and psychological distress (Brief Sy...
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| Veröffentlicht in: | Journal of hepatology 2000-10, Vol.33 (4), p.609-615 |
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| creator | Bona, Manuela De Ponton, Paola Ermani, Mario Iemmolo, Rosa Maria Feltrin, Alessandra Boccagni, Patrizia Gerunda, Giorgio Naccarato, Remo Rupolo, Giampietro Burra, Patrizia |
| description | Background/Aim: The impact of liver disease and medical complications on quality of life (QOL) and psychological distress before and after orthotopic liver transplantation (OLT) is a matter of growing interest.
Methods: Perceived QOL (LEIPAD Quality of Life test) and psychological distress (Brief Symptom Inventory, BSI) were assessed in 40 cirrhotic patients listed for OLT (Group A) and in 101 liver transplant recipients (Groups B to G=0–6, 7–12, 13–24, 25–36, 37–48, 49–60 months post-OLT). Patients were also evaluated for medical complications, blood levels of immunosuppressive agents and recurrence of liver disease.
Results: QOL and psychological distress were significantly better in most of the post-OLT groups than in cirrhotic patients. Among post-OLT patients, a significantly worse QOL was perceived at 13–24 months (Life Satisfaction: Group D
vs G,
p=0.024; Cognitive Functioning: Group D
vs F,
p=0.024), while significantly greater psychological distress was detected at 7–12 months (Anxiety and Interpersonal Sensitivity: Group C
vs Group B,
p=0.032 and
p=0.023, respectively). Medical complications and immunosuppressive therapy did not influence QOL or psychological distress after OLT. Within 6 months after OLT, patients with HCV recurrence showed significantly greater Depression (
p=0.023), Anxiety (
p=0.038), Phobic Anxiety (
p=0.001), and Paranoid Ideation (
p=0.033) than anti-HCV negative patients.
Conclusions: Liver transplantation improves psychological distress and most, but not all, QOL domains. Recurrent HCV infection is associated with greater psychological distress. |
| doi_str_mv | 10.1016/S0168-8278(00)80012-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72376702</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827800800124</els_id><sourcerecordid>72376702</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2375-20ea7f0e19d50572aeb7df2bbc8974e056539e5486f32b1cf9f6c5b6a686f5573</originalsourceid><addsrcrecordid>eNqFkc1u1TAQhS0EopfCI4C8QAgWgXES28mqQhV_UiUWlLXlOGNqlMSpx7fSfQWeGvfmii7Z2Jb1nTmjcxh7KeC9AKE-_ChHV3W17t4CvOsARF21j9hOKIAKVCses90_5Iw9I_oNAA307VN2JgTIvlNyx_5c3yAP82pd5tHzKdxh4mMgtITcLiOfcQzOTtzFeZ3KK4e4EI8Lv93bKeTDpvIbvNLB3cQp_jpKypickIgP6GPaCOtzMdhscrILrZNd8nHqc_bE24nwxek-Zz8_f7q-_Fpdff_y7fLjVeXqRsuqBrTaA4p-lCB1bXHQo6-HwXW9bhGkkk2Psu2Ub-pBON975eSgrCo_UurmnL3Z5q4p3u6RspkDOZzKIhj3ZHSxURrqAsoNdCkSJfRmTWG26WAEmPsSzLEEc5-wATDHEkxbdK9OBvuhxPegOqVegNcnwFIJypccXKAHrtVdq5qCXWwYljTuAiZDLuDiSiMJXTZjDP_Z5C9pZqXo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72376702</pqid></control><display><type>article</type><title>The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Bona, Manuela De ; Ponton, Paola ; Ermani, Mario ; Iemmolo, Rosa Maria ; Feltrin, Alessandra ; Boccagni, Patrizia ; Gerunda, Giorgio ; Naccarato, Remo ; Rupolo, Giampietro ; Burra, Patrizia</creator><creatorcontrib>Bona, Manuela De ; Ponton, Paola ; Ermani, Mario ; Iemmolo, Rosa Maria ; Feltrin, Alessandra ; Boccagni, Patrizia ; Gerunda, Giorgio ; Naccarato, Remo ; Rupolo, Giampietro ; Burra, Patrizia</creatorcontrib><description>Background/Aim: The impact of liver disease and medical complications on quality of life (QOL) and psychological distress before and after orthotopic liver transplantation (OLT) is a matter of growing interest.
Methods: Perceived QOL (LEIPAD Quality of Life test) and psychological distress (Brief Symptom Inventory, BSI) were assessed in 40 cirrhotic patients listed for OLT (Group A) and in 101 liver transplant recipients (Groups B to G=0–6, 7–12, 13–24, 25–36, 37–48, 49–60 months post-OLT). Patients were also evaluated for medical complications, blood levels of immunosuppressive agents and recurrence of liver disease.
Results: QOL and psychological distress were significantly better in most of the post-OLT groups than in cirrhotic patients. Among post-OLT patients, a significantly worse QOL was perceived at 13–24 months (Life Satisfaction: Group D
vs G,
p=0.024; Cognitive Functioning: Group D
vs F,
p=0.024), while significantly greater psychological distress was detected at 7–12 months (Anxiety and Interpersonal Sensitivity: Group C
vs Group B,
p=0.032 and
p=0.023, respectively). Medical complications and immunosuppressive therapy did not influence QOL or psychological distress after OLT. Within 6 months after OLT, patients with HCV recurrence showed significantly greater Depression (
p=0.023), Anxiety (
p=0.038), Phobic Anxiety (
p=0.001), and Paranoid Ideation (
p=0.033) than anti-HCV negative patients.
Conclusions: Liver transplantation improves psychological distress and most, but not all, QOL domains. Recurrent HCV infection is associated with greater psychological distress.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(00)80012-4</identifier><identifier>PMID: 11059865</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Aged ; Anxiety ; Biological and medical sciences ; Cirrhosis ; Depression ; Female ; Follow-Up Studies ; Hepatitis C - physiopathology ; Hepatitis C - psychology ; Hepatitis C - surgery ; Humans ; Immunosuppressive Agents - blood ; Immunosuppressive Agents - therapeutic use ; Immunosuppressive therapy ; Interpersonal Relations ; Liver Cirrhosis - complications ; Liver Cirrhosis - physiopathology ; Liver Cirrhosis - psychology ; Liver Cirrhosis - surgery ; Liver transplantation ; Liver Transplantation - immunology ; Liver Transplantation - physiology ; Liver Transplantation - psychology ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical complications ; Medical sciences ; Middle Aged ; Paranoid Disorders ; Phobic Disorders ; Psychological distress ; Psychological Tests ; Quality of Life ; Recurrence ; Recurrence of liver disease ; Stress, Psychological - etiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Time Factors</subject><ispartof>Journal of hepatology, 2000-10, Vol.33 (4), p.609-615</ispartof><rights>2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2375-20ea7f0e19d50572aeb7df2bbc8974e056539e5486f32b1cf9f6c5b6a686f5573</citedby><cites>FETCH-LOGICAL-c2375-20ea7f0e19d50572aeb7df2bbc8974e056539e5486f32b1cf9f6c5b6a686f5573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8278(00)80012-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1478463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11059865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bona, Manuela De</creatorcontrib><creatorcontrib>Ponton, Paola</creatorcontrib><creatorcontrib>Ermani, Mario</creatorcontrib><creatorcontrib>Iemmolo, Rosa Maria</creatorcontrib><creatorcontrib>Feltrin, Alessandra</creatorcontrib><creatorcontrib>Boccagni, Patrizia</creatorcontrib><creatorcontrib>Gerunda, Giorgio</creatorcontrib><creatorcontrib>Naccarato, Remo</creatorcontrib><creatorcontrib>Rupolo, Giampietro</creatorcontrib><creatorcontrib>Burra, Patrizia</creatorcontrib><title>The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background/Aim: The impact of liver disease and medical complications on quality of life (QOL) and psychological distress before and after orthotopic liver transplantation (OLT) is a matter of growing interest.
Methods: Perceived QOL (LEIPAD Quality of Life test) and psychological distress (Brief Symptom Inventory, BSI) were assessed in 40 cirrhotic patients listed for OLT (Group A) and in 101 liver transplant recipients (Groups B to G=0–6, 7–12, 13–24, 25–36, 37–48, 49–60 months post-OLT). Patients were also evaluated for medical complications, blood levels of immunosuppressive agents and recurrence of liver disease.
Results: QOL and psychological distress were significantly better in most of the post-OLT groups than in cirrhotic patients. Among post-OLT patients, a significantly worse QOL was perceived at 13–24 months (Life Satisfaction: Group D
vs G,
p=0.024; Cognitive Functioning: Group D
vs F,
p=0.024), while significantly greater psychological distress was detected at 7–12 months (Anxiety and Interpersonal Sensitivity: Group C
vs Group B,
p=0.032 and
p=0.023, respectively). Medical complications and immunosuppressive therapy did not influence QOL or psychological distress after OLT. Within 6 months after OLT, patients with HCV recurrence showed significantly greater Depression (
p=0.023), Anxiety (
p=0.038), Phobic Anxiety (
p=0.001), and Paranoid Ideation (
p=0.033) than anti-HCV negative patients.
Conclusions: Liver transplantation improves psychological distress and most, but not all, QOL domains. Recurrent HCV infection is associated with greater psychological distress.</description><subject>Adult</subject><subject>Aged</subject><subject>Anxiety</subject><subject>Biological and medical sciences</subject><subject>Cirrhosis</subject><subject>Depression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hepatitis C - physiopathology</subject><subject>Hepatitis C - psychology</subject><subject>Hepatitis C - surgery</subject><subject>Humans</subject><subject>Immunosuppressive Agents - blood</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Immunosuppressive therapy</subject><subject>Interpersonal Relations</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver Cirrhosis - psychology</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - immunology</subject><subject>Liver Transplantation - physiology</subject><subject>Liver Transplantation - psychology</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical complications</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Paranoid Disorders</subject><subject>Phobic Disorders</subject><subject>Psychological distress</subject><subject>Psychological Tests</subject><subject>Quality of Life</subject><subject>Recurrence</subject><subject>Recurrence of liver disease</subject><subject>Stress, Psychological - etiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Time Factors</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCI4C8QAgWgXES28mqQhV_UiUWlLXlOGNqlMSpx7fSfQWeGvfmii7Z2Jb1nTmjcxh7KeC9AKE-_ChHV3W17t4CvOsARF21j9hOKIAKVCses90_5Iw9I_oNAA307VN2JgTIvlNyx_5c3yAP82pd5tHzKdxh4mMgtITcLiOfcQzOTtzFeZ3KK4e4EI8Lv93bKeTDpvIbvNLB3cQp_jpKypickIgP6GPaCOtzMdhscrILrZNd8nHqc_bE24nwxek-Zz8_f7q-_Fpdff_y7fLjVeXqRsuqBrTaA4p-lCB1bXHQo6-HwXW9bhGkkk2Psu2Ub-pBON975eSgrCo_UurmnL3Z5q4p3u6RspkDOZzKIhj3ZHSxURrqAsoNdCkSJfRmTWG26WAEmPsSzLEEc5-wATDHEkxbdK9OBvuhxPegOqVegNcnwFIJypccXKAHrtVdq5qCXWwYljTuAiZDLuDiSiMJXTZjDP_Z5C9pZqXo</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Bona, Manuela De</creator><creator>Ponton, Paola</creator><creator>Ermani, Mario</creator><creator>Iemmolo, Rosa Maria</creator><creator>Feltrin, Alessandra</creator><creator>Boccagni, Patrizia</creator><creator>Gerunda, Giorgio</creator><creator>Naccarato, Remo</creator><creator>Rupolo, Giampietro</creator><creator>Burra, Patrizia</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation</title><author>Bona, Manuela De ; Ponton, Paola ; Ermani, Mario ; Iemmolo, Rosa Maria ; Feltrin, Alessandra ; Boccagni, Patrizia ; Gerunda, Giorgio ; Naccarato, Remo ; Rupolo, Giampietro ; Burra, Patrizia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2375-20ea7f0e19d50572aeb7df2bbc8974e056539e5486f32b1cf9f6c5b6a686f5573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anxiety</topic><topic>Biological and medical sciences</topic><topic>Cirrhosis</topic><topic>Depression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hepatitis C - physiopathology</topic><topic>Hepatitis C - psychology</topic><topic>Hepatitis C - surgery</topic><topic>Humans</topic><topic>Immunosuppressive Agents - blood</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Immunosuppressive therapy</topic><topic>Interpersonal Relations</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver Cirrhosis - psychology</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - immunology</topic><topic>Liver Transplantation - physiology</topic><topic>Liver Transplantation - psychology</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical complications</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Paranoid Disorders</topic><topic>Phobic Disorders</topic><topic>Psychological distress</topic><topic>Psychological Tests</topic><topic>Quality of Life</topic><topic>Recurrence</topic><topic>Recurrence of liver disease</topic><topic>Stress, Psychological - etiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bona, Manuela De</creatorcontrib><creatorcontrib>Ponton, Paola</creatorcontrib><creatorcontrib>Ermani, Mario</creatorcontrib><creatorcontrib>Iemmolo, Rosa Maria</creatorcontrib><creatorcontrib>Feltrin, Alessandra</creatorcontrib><creatorcontrib>Boccagni, Patrizia</creatorcontrib><creatorcontrib>Gerunda, Giorgio</creatorcontrib><creatorcontrib>Naccarato, Remo</creatorcontrib><creatorcontrib>Rupolo, Giampietro</creatorcontrib><creatorcontrib>Burra, Patrizia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bona, Manuela De</au><au>Ponton, Paola</au><au>Ermani, Mario</au><au>Iemmolo, Rosa Maria</au><au>Feltrin, Alessandra</au><au>Boccagni, Patrizia</au><au>Gerunda, Giorgio</au><au>Naccarato, Remo</au><au>Rupolo, Giampietro</au><au>Burra, Patrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2000-10</date><risdate>2000</risdate><volume>33</volume><issue>4</issue><spage>609</spage><epage>615</epage><pages>609-615</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background/Aim: The impact of liver disease and medical complications on quality of life (QOL) and psychological distress before and after orthotopic liver transplantation (OLT) is a matter of growing interest.
Methods: Perceived QOL (LEIPAD Quality of Life test) and psychological distress (Brief Symptom Inventory, BSI) were assessed in 40 cirrhotic patients listed for OLT (Group A) and in 101 liver transplant recipients (Groups B to G=0–6, 7–12, 13–24, 25–36, 37–48, 49–60 months post-OLT). Patients were also evaluated for medical complications, blood levels of immunosuppressive agents and recurrence of liver disease.
Results: QOL and psychological distress were significantly better in most of the post-OLT groups than in cirrhotic patients. Among post-OLT patients, a significantly worse QOL was perceived at 13–24 months (Life Satisfaction: Group D
vs G,
p=0.024; Cognitive Functioning: Group D
vs F,
p=0.024), while significantly greater psychological distress was detected at 7–12 months (Anxiety and Interpersonal Sensitivity: Group C
vs Group B,
p=0.032 and
p=0.023, respectively). Medical complications and immunosuppressive therapy did not influence QOL or psychological distress after OLT. Within 6 months after OLT, patients with HCV recurrence showed significantly greater Depression (
p=0.023), Anxiety (
p=0.038), Phobic Anxiety (
p=0.001), and Paranoid Ideation (
p=0.033) than anti-HCV negative patients.
Conclusions: Liver transplantation improves psychological distress and most, but not all, QOL domains. Recurrent HCV infection is associated with greater psychological distress.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>11059865</pmid><doi>10.1016/S0168-8278(00)80012-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 2000-10, Vol.33 (4), p.609-615 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Anxiety Biological and medical sciences Cirrhosis Depression Female Follow-Up Studies Hepatitis C - physiopathology Hepatitis C - psychology Hepatitis C - surgery Humans Immunosuppressive Agents - blood Immunosuppressive Agents - therapeutic use Immunosuppressive therapy Interpersonal Relations Liver Cirrhosis - complications Liver Cirrhosis - physiopathology Liver Cirrhosis - psychology Liver Cirrhosis - surgery Liver transplantation Liver Transplantation - immunology Liver Transplantation - physiology Liver Transplantation - psychology Liver, biliary tract, pancreas, portal circulation, spleen Male Medical complications Medical sciences Middle Aged Paranoid Disorders Phobic Disorders Psychological distress Psychological Tests Quality of Life Recurrence Recurrence of liver disease Stress, Psychological - etiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Time Factors |
| title | The impact of liver disease and medical complications on quality of life and psychological distress before and after liver transplantation |
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