Estimation of striatal dopamine spillover and metabolism in vivo

A microdialysis probe with an attached microinjection cannula was inserted into rat striatum. [H]dopamine (or [C]sucrose as a reference substance for diffusion) was infused via the cannula, with microdialysate sampled for concentrations of endogenous and [H]-labeled dopamine and its metabolites. The...

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Veröffentlicht in:	Neuroreport 2000-10, Vol.11 (15), p.3367-3373
Hauptverfasser:	Yadid, Gal, Harvey-White, Judith Dale, Kopin, Irwin J, Goldstein, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Corpus Striatum - metabolism Dopamine - metabolism Fundamental and applied biological sciences. Psychology Homovanillic Acid - metabolism Injections Male Medial Forebrain Bundle - drug effects Medial Forebrain Bundle - physiology Microdialysis Osmolar Concentration Oxidopamine - pharmacology Rats Rats, Sprague-Dawley Sucrose - metabolism Vertebrates: nervous system and sense organs
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