Vaccination with a Nogo-A-Derived Peptide after Incomplete Spinal-Cord Injury Promotes Recovery via a T-Cell-Mediated Neuroprotective Response: Comparison with Other Myelin Antigens

The myelin-associated protein Nogo-A has received more research attention than any other inhibitor of axonal regeneration in the injured central nervous system (CNS). Circumvention of its inhibitory effect, by using antibodies specific to Nogo-A, has been shown to promote axonal regrowth. Studies in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-12, Vol.98 (26), p.15173-15178
Hauptverfasser:	Hauben, Ehud, Ibarra, Antonio, Mizrahi, Tal, Barouch, Rina, Agranov, Eugenia, Schwartz, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Antigens Antigens - immunology Biological Sciences Bruises Central nervous system Immunization Molecular Sequence Data myelin Myelin Proteins - chemistry Myelin Sheath - immunology Neuroscience Nogo protein Nogo Proteins Nogo-A protein Peptide Fragments - administration & dosage Peptide Fragments - chemistry Peptide Fragments - immunology Physical trauma Rats Rats, Inbred Lew Rats, Sprague-Dawley Spinal cord Spinal Cord - immunology Spinal Cord - pathology Spinal Cord Injuries - immunology T lymphocytes T-Lymphocytes - immunology Vaccination Vaccines - administration & dosage Vaccines - immunology
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