Protection of the lungs from acid during aspiration
Unlike the thick mucosa that normally covers the upper gastrointestinal tract, the membranes that cover the distal surfaces of the lungs are remarkably attenuated. This permits rapid exchange of gases between the airspaces and pulmonary vasculature, and may make the lungs more susceptible to acid ch...
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| Veröffentlicht in: | The American journal of medicine 2001-12, Vol.111 (8), p.56-59 |
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| creator | Effros, Richard M. Hogan, Genevieve Wahlen Hoagland, Kelly Olson, Lars Lin, Wen |
| description | Unlike the thick mucosa that normally covers the upper gastrointestinal tract, the membranes that cover the distal surfaces of the lungs are remarkably attenuated. This permits rapid exchange of gases between the airspaces and pulmonary vasculature, and may make the lungs more susceptible to acid challenges associated with acid reflux and aspiration. Any injury to the alveolar epithelium could result in the movement of solute and water into the airspaces (chemical pneumonia) and impair gas exchange. In this study, we used a fluorescent approach to compare the relative permeability of the apical basolateral surfaces of the lungs to the exchange of the ionic forms of acids and bases. The apical membranes proved to be much less permeable to NH
4
+ and HCO
3
+ than the basolateral membranes. This asymmetry in permeability should enhance resistance of the epithelium to inspired acidic challenges by slowing entry of acid into the cells and by linking the intracellular pH of the alveolar cells to that of the plasma, which is a relatively large, well-buffered compartment. Evidence also was obtained that the acid is secreted by the membranes covering the lungs. |
| doi_str_mv | 10.1016/S0002-9343(01)00822-1 |
| format | Article |
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4
+ and HCO
3
+ than the basolateral membranes. This asymmetry in permeability should enhance resistance of the epithelium to inspired acidic challenges by slowing entry of acid into the cells and by linking the intracellular pH of the alveolar cells to that of the plasma, which is a relatively large, well-buffered compartment. Evidence also was obtained that the acid is secreted by the membranes covering the lungs.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/S0002-9343(01)00822-1</identifier><identifier>PMID: 11749926</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Ammonium Chloride - pharmacology ; Animals ; Biological and medical sciences ; Cell Membrane Permeability - physiology ; Culture Techniques ; Digestive system ; Disease ; Fluorescence ; Gastric Acid - chemistry ; Hydrogen-Ion Concentration ; Inhalation - physiology ; Investigative techniques, diagnostic techniques (general aspects) ; Lung - drug effects ; Lung - physiology ; Lungs ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Rats ; Reference Values ; Stomach</subject><ispartof>The American journal of medicine, 2001-12, Vol.111 (8), p.56-59</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Dec 3, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-651bef7377ca65bf3c63a0481a19018568a93b43469b13ce018e55b066dc74e3</citedby><cites>FETCH-LOGICAL-c418t-651bef7377ca65bf3c63a0481a19018568a93b43469b13ce018e55b066dc74e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002934301008221$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13393268$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11749926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Effros, Richard M.</creatorcontrib><creatorcontrib>Hogan, Genevieve</creatorcontrib><creatorcontrib>Wahlen Hoagland, Kelly</creatorcontrib><creatorcontrib>Olson, Lars</creatorcontrib><creatorcontrib>Lin, Wen</creatorcontrib><title>Protection of the lungs from acid during aspiration</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Unlike the thick mucosa that normally covers the upper gastrointestinal tract, the membranes that cover the distal surfaces of the lungs are remarkably attenuated. This permits rapid exchange of gases between the airspaces and pulmonary vasculature, and may make the lungs more susceptible to acid challenges associated with acid reflux and aspiration. Any injury to the alveolar epithelium could result in the movement of solute and water into the airspaces (chemical pneumonia) and impair gas exchange. In this study, we used a fluorescent approach to compare the relative permeability of the apical basolateral surfaces of the lungs to the exchange of the ionic forms of acids and bases. The apical membranes proved to be much less permeable to NH
4
+ and HCO
3
+ than the basolateral membranes. This asymmetry in permeability should enhance resistance of the epithelium to inspired acidic challenges by slowing entry of acid into the cells and by linking the intracellular pH of the alveolar cells to that of the plasma, which is a relatively large, well-buffered compartment. Evidence also was obtained that the acid is secreted by the membranes covering the lungs.</description><subject>Ammonium Chloride - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane Permeability - physiology</subject><subject>Culture Techniques</subject><subject>Digestive system</subject><subject>Disease</subject><subject>Fluorescence</subject><subject>Gastric Acid - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Inhalation - physiology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>Lungs</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Miscellaneous investigative techniques</topic><topic>Rats</topic><topic>Reference Values</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Effros, Richard M.</creatorcontrib><creatorcontrib>Hogan, Genevieve</creatorcontrib><creatorcontrib>Wahlen Hoagland, Kelly</creatorcontrib><creatorcontrib>Olson, Lars</creatorcontrib><creatorcontrib>Lin, Wen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Effros, Richard M.</au><au>Hogan, Genevieve</au><au>Wahlen Hoagland, Kelly</au><au>Olson, Lars</au><au>Lin, Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection of the lungs from acid during aspiration</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>2001-12-03</date><risdate>2001</risdate><volume>111</volume><issue>8</issue><spage>56</spage><epage>59</epage><pages>56-59</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>Unlike the thick mucosa that normally covers the upper gastrointestinal tract, the membranes that cover the distal surfaces of the lungs are remarkably attenuated. This permits rapid exchange of gases between the airspaces and pulmonary vasculature, and may make the lungs more susceptible to acid challenges associated with acid reflux and aspiration. Any injury to the alveolar epithelium could result in the movement of solute and water into the airspaces (chemical pneumonia) and impair gas exchange. In this study, we used a fluorescent approach to compare the relative permeability of the apical basolateral surfaces of the lungs to the exchange of the ionic forms of acids and bases. The apical membranes proved to be much less permeable to NH
4
+ and HCO
3
+ than the basolateral membranes. This asymmetry in permeability should enhance resistance of the epithelium to inspired acidic challenges by slowing entry of acid into the cells and by linking the intracellular pH of the alveolar cells to that of the plasma, which is a relatively large, well-buffered compartment. Evidence also was obtained that the acid is secreted by the membranes covering the lungs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11749926</pmid><doi>10.1016/S0002-9343(01)00822-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Ammonium Chloride - pharmacology Animals Biological and medical sciences Cell Membrane Permeability - physiology Culture Techniques Digestive system Disease Fluorescence Gastric Acid - chemistry Hydrogen-Ion Concentration Inhalation - physiology Investigative techniques, diagnostic techniques (general aspects) Lung - drug effects Lung - physiology Lungs Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Reference Values Stomach |
| title | Protection of the lungs from acid during aspiration |
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