Effects of Antihypertensive Agents on Blood Pressure during Exercise
The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be repressentative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little info...
Gespeichert in:
| Veröffentlicht in: | Hypertension Research 2001, Vol.24(6), pp.671-678 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 678 |
|---|---|
| container_issue | 6 |
| container_start_page | 671 |
| container_title | Hypertension Research |
| container_volume | 24 |
| creator | ARITA, Mikio HASHIZUME, Toshikazu WANAKA, Yoshio HANDA, Satoshi NAKAMURA, Chigusa FUJIWARA, Setsuko NISHIO, Ichiro |
| description | The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be repressentative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little information about the effects of antihypertensive drugs on the BP during exercise. This study was designed to investigate the effects of various antihypertensive agents on BP during exercise. Sixty-four patients (age, 49±10 years) with untreated essential hypertension (WHO I, II) were studied during a supine ergometric exercise regimen. A graded exercise test was started at a workload of 50 W, and the load was increased by 25 W every 3 min. The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic BP (SBP, DBP) and heart rate (HR). Plasma norepinephrine (NE) levels were measured at rest and during submaximal exercise, and before and after 4 weeks of treatment with metoprolol (METO), doxazosin (DOXA), trichlormethiazide (TCTZ), nifedipine (NIFE), amlodipine (AMLO) and temocapril (TEMO) between left ventricular mass index (LVMI) and BP values at rest, during exercise, and during the recovery period after exercise were assessed by multiple reguression analysis. The stepwise selection (forward conditional) method showed that LVMI was significantly associated with SBP during submaximal exercise and during the recovery period. All antihypertensive treatments decreased SBP and DBP (p |
| doi_str_mv | 10.1291/hypres.24.671 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72375288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72375288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c578t-e40317dc32fa4e0b7c2b051622dd47e49d971a88cc6fab6d79ee0ebb9310fdbe3</originalsourceid><addsrcrecordid>eNpNkD1PwzAQQC0EoqUwsqJMbCn-qh2PbSkfUiUYYLYc-9ymSpNiJ4j-e1KlKix3wz29kx5CtwSPCVXkYb3fBYhjysdCkjM0JIxnKaeEn6MhVkSkSjAxQFcxbjCm2USRSzQgRIpMUjFEjwvvwTYxqX0yrZqi00FooIrFNyTTFVSHU5XMyrp2yXv3KbYBEteGololix8ItohwjS68KSPcHPcIfT4tPuYv6fLt-XU-XaZ2IrMmBY4Zkc4y6g0HnEtLczwhglLnuASunJLEZJm1wptcOKkAMOS5YgR7lwMbofveuwv1Vwux0dsiWihLU0HdRi0pkxOaZR2Y9qANdYwBvN6FYmvCXhOsD9l0n01TrrtsHX93FLf5FtwffezUAbMe2MTGrOAEmNAUtoT_un501tPRrk3QULFfJySDSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72375288</pqid></control><display><type>article</type><title>Effects of Antihypertensive Agents on Blood Pressure during Exercise</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>ARITA, Mikio ; HASHIZUME, Toshikazu ; WANAKA, Yoshio ; HANDA, Satoshi ; NAKAMURA, Chigusa ; FUJIWARA, Setsuko ; NISHIO, Ichiro</creator><creatorcontrib>ARITA, Mikio ; HASHIZUME, Toshikazu ; WANAKA, Yoshio ; HANDA, Satoshi ; NAKAMURA, Chigusa ; FUJIWARA, Setsuko ; NISHIO, Ichiro</creatorcontrib><description>The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be repressentative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little information about the effects of antihypertensive drugs on the BP during exercise. This study was designed to investigate the effects of various antihypertensive agents on BP during exercise. Sixty-four patients (age, 49±10 years) with untreated essential hypertension (WHO I, II) were studied during a supine ergometric exercise regimen. A graded exercise test was started at a workload of 50 W, and the load was increased by 25 W every 3 min. The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic BP (SBP, DBP) and heart rate (HR). Plasma norepinephrine (NE) levels were measured at rest and during submaximal exercise, and before and after 4 weeks of treatment with metoprolol (METO), doxazosin (DOXA), trichlormethiazide (TCTZ), nifedipine (NIFE), amlodipine (AMLO) and temocapril (TEMO) between left ventricular mass index (LVMI) and BP values at rest, during exercise, and during the recovery period after exercise were assessed by multiple reguression analysis. The stepwise selection (forward conditional) method showed that LVMI was significantly associated with SBP during submaximal exercise and during the recovery period. All antihypertensive treatments decreased SBP and DBP (p<0.01) at rest. METO, AMLO and TEMO significantly lowered SBP (p<0.05) during exercise, whereas DOXA, TCTZ and NIFE induced no change in SBP. The exercise-induced increase of plasma NE was further enhanced by METO and NIFE but not by AMLO, DOXA, or TCTZ, and it was significantly suppressed by TEMO (p<0.01). There results suggest that BP during exercise is more highly associated with the progression of left ventricular hypertrophy (LVH) than is casual BP. Because antihypertensive agents differ in their effects on exercise hemodynamics, we recommend that hemodynamic factors during exercise be considered when selecting the optimal antihypertensive medication for highly active patients. (Hypertens Res 2001; 24: 671-678)</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1291/hypres.24.671</identifier><identifier>PMID: 11768726</identifier><language>eng</language><publisher>England: The Japanese Society of Hypertension</publisher><subject>Adult ; antihypertensive agents ; Antihypertensive Agents - therapeutic use ; Blood Pressure - drug effects ; blood pressure during exercise ; Echocardiography ; Exercise - physiology ; Exercise Test ; Female ; Hemodynamics - drug effects ; Humans ; Hypertension - drug therapy ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - diagnostic imaging ; left ventricular hypertrophy ; Male ; Middle Aged ; plasma norepinephrine</subject><ispartof>Hypertension Research, 2001, Vol.24(6), pp.671-678</ispartof><rights>2001 by the Japanese Society of Hypertension</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-e40317dc32fa4e0b7c2b051622dd47e49d971a88cc6fab6d79ee0ebb9310fdbe3</citedby><cites>FETCH-LOGICAL-c578t-e40317dc32fa4e0b7c2b051622dd47e49d971a88cc6fab6d79ee0ebb9310fdbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11768726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARITA, Mikio</creatorcontrib><creatorcontrib>HASHIZUME, Toshikazu</creatorcontrib><creatorcontrib>WANAKA, Yoshio</creatorcontrib><creatorcontrib>HANDA, Satoshi</creatorcontrib><creatorcontrib>NAKAMURA, Chigusa</creatorcontrib><creatorcontrib>FUJIWARA, Setsuko</creatorcontrib><creatorcontrib>NISHIO, Ichiro</creatorcontrib><title>Effects of Antihypertensive Agents on Blood Pressure during Exercise</title><title>Hypertension Research</title><addtitle>Hypertension Research</addtitle><description>The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be repressentative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little information about the effects of antihypertensive drugs on the BP during exercise. This study was designed to investigate the effects of various antihypertensive agents on BP during exercise. Sixty-four patients (age, 49±10 years) with untreated essential hypertension (WHO I, II) were studied during a supine ergometric exercise regimen. A graded exercise test was started at a workload of 50 W, and the load was increased by 25 W every 3 min. The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic BP (SBP, DBP) and heart rate (HR). Plasma norepinephrine (NE) levels were measured at rest and during submaximal exercise, and before and after 4 weeks of treatment with metoprolol (METO), doxazosin (DOXA), trichlormethiazide (TCTZ), nifedipine (NIFE), amlodipine (AMLO) and temocapril (TEMO) between left ventricular mass index (LVMI) and BP values at rest, during exercise, and during the recovery period after exercise were assessed by multiple reguression analysis. The stepwise selection (forward conditional) method showed that LVMI was significantly associated with SBP during submaximal exercise and during the recovery period. All antihypertensive treatments decreased SBP and DBP (p<0.01) at rest. METO, AMLO and TEMO significantly lowered SBP (p<0.05) during exercise, whereas DOXA, TCTZ and NIFE induced no change in SBP. The exercise-induced increase of plasma NE was further enhanced by METO and NIFE but not by AMLO, DOXA, or TCTZ, and it was significantly suppressed by TEMO (p<0.01). There results suggest that BP during exercise is more highly associated with the progression of left ventricular hypertrophy (LVH) than is casual BP. Because antihypertensive agents differ in their effects on exercise hemodynamics, we recommend that hemodynamic factors during exercise be considered when selecting the optimal antihypertensive medication for highly active patients. (Hypertens Res 2001; 24: 671-678)</description><subject>Adult</subject><subject>antihypertensive agents</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>blood pressure during exercise</subject><subject>Echocardiography</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>left ventricular hypertrophy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>plasma norepinephrine</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1PwzAQQC0EoqUwsqJMbCn-qh2PbSkfUiUYYLYc-9ymSpNiJ4j-e1KlKix3wz29kx5CtwSPCVXkYb3fBYhjysdCkjM0JIxnKaeEn6MhVkSkSjAxQFcxbjCm2USRSzQgRIpMUjFEjwvvwTYxqX0yrZqi00FooIrFNyTTFVSHU5XMyrp2yXv3KbYBEteGololix8ItohwjS68KSPcHPcIfT4tPuYv6fLt-XU-XaZ2IrMmBY4Zkc4y6g0HnEtLczwhglLnuASunJLEZJm1wptcOKkAMOS5YgR7lwMbofveuwv1Vwux0dsiWihLU0HdRi0pkxOaZR2Y9qANdYwBvN6FYmvCXhOsD9l0n01TrrtsHX93FLf5FtwffezUAbMe2MTGrOAEmNAUtoT_un501tPRrk3QULFfJySDSg</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>ARITA, Mikio</creator><creator>HASHIZUME, Toshikazu</creator><creator>WANAKA, Yoshio</creator><creator>HANDA, Satoshi</creator><creator>NAKAMURA, Chigusa</creator><creator>FUJIWARA, Setsuko</creator><creator>NISHIO, Ichiro</creator><general>The Japanese Society of Hypertension</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Effects of Antihypertensive Agents on Blood Pressure during Exercise</title><author>ARITA, Mikio ; HASHIZUME, Toshikazu ; WANAKA, Yoshio ; HANDA, Satoshi ; NAKAMURA, Chigusa ; FUJIWARA, Setsuko ; NISHIO, Ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-e40317dc32fa4e0b7c2b051622dd47e49d971a88cc6fab6d79ee0ebb9310fdbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>antihypertensive agents</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Blood Pressure - drug effects</topic><topic>blood pressure during exercise</topic><topic>Echocardiography</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>left ventricular hypertrophy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>plasma norepinephrine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARITA, Mikio</creatorcontrib><creatorcontrib>HASHIZUME, Toshikazu</creatorcontrib><creatorcontrib>WANAKA, Yoshio</creatorcontrib><creatorcontrib>HANDA, Satoshi</creatorcontrib><creatorcontrib>NAKAMURA, Chigusa</creatorcontrib><creatorcontrib>FUJIWARA, Setsuko</creatorcontrib><creatorcontrib>NISHIO, Ichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARITA, Mikio</au><au>HASHIZUME, Toshikazu</au><au>WANAKA, Yoshio</au><au>HANDA, Satoshi</au><au>NAKAMURA, Chigusa</au><au>FUJIWARA, Setsuko</au><au>NISHIO, Ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Antihypertensive Agents on Blood Pressure during Exercise</atitle><jtitle>Hypertension Research</jtitle><addtitle>Hypertension Research</addtitle><date>2001</date><risdate>2001</risdate><volume>24</volume><issue>6</issue><spage>671</spage><epage>678</epage><pages>671-678</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>The relationship between blood pressure (BP) and cardiovascular morbidity has been appreciated for many years. Casual BP may not be repressentative of the pressure at other times. It is recognized that BP during exercise may be a more accurate predictor than casual BP. There is, however, little information about the effects of antihypertensive drugs on the BP during exercise. This study was designed to investigate the effects of various antihypertensive agents on BP during exercise. Sixty-four patients (age, 49±10 years) with untreated essential hypertension (WHO I, II) were studied during a supine ergometric exercise regimen. A graded exercise test was started at a workload of 50 W, and the load was increased by 25 W every 3 min. The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic BP (SBP, DBP) and heart rate (HR). Plasma norepinephrine (NE) levels were measured at rest and during submaximal exercise, and before and after 4 weeks of treatment with metoprolol (METO), doxazosin (DOXA), trichlormethiazide (TCTZ), nifedipine (NIFE), amlodipine (AMLO) and temocapril (TEMO) between left ventricular mass index (LVMI) and BP values at rest, during exercise, and during the recovery period after exercise were assessed by multiple reguression analysis. The stepwise selection (forward conditional) method showed that LVMI was significantly associated with SBP during submaximal exercise and during the recovery period. All antihypertensive treatments decreased SBP and DBP (p<0.01) at rest. METO, AMLO and TEMO significantly lowered SBP (p<0.05) during exercise, whereas DOXA, TCTZ and NIFE induced no change in SBP. The exercise-induced increase of plasma NE was further enhanced by METO and NIFE but not by AMLO, DOXA, or TCTZ, and it was significantly suppressed by TEMO (p<0.01). There results suggest that BP during exercise is more highly associated with the progression of left ventricular hypertrophy (LVH) than is casual BP. Because antihypertensive agents differ in their effects on exercise hemodynamics, we recommend that hemodynamic factors during exercise be considered when selecting the optimal antihypertensive medication for highly active patients. (Hypertens Res 2001; 24: 671-678)</abstract><cop>England</cop><pub>The Japanese Society of Hypertension</pub><pmid>11768726</pmid><doi>10.1291/hypres.24.671</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-9636 |
| ispartof | Hypertension Research, 2001, Vol.24(6), pp.671-678 |
| issn | 0916-9636 1348-4214 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72375288 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult antihypertensive agents Antihypertensive Agents - therapeutic use Blood Pressure - drug effects blood pressure during exercise Echocardiography Exercise - physiology Exercise Test Female Hemodynamics - drug effects Humans Hypertension - drug therapy Hypertension - physiopathology Hypertrophy, Left Ventricular - diagnostic imaging left ventricular hypertrophy Male Middle Aged plasma norepinephrine |
| title | Effects of Antihypertensive Agents on Blood Pressure during Exercise |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A00%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Antihypertensive%20Agents%20on%20Blood%20Pressure%20during%20Exercise&rft.jtitle=Hypertension%20Research&rft.au=ARITA,%20Mikio&rft.date=2001&rft.volume=24&rft.issue=6&rft.spage=671&rft.epage=678&rft.pages=671-678&rft.issn=0916-9636&rft.eissn=1348-4214&rft_id=info:doi/10.1291/hypres.24.671&rft_dat=%3Cproquest_cross%3E72375288%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72375288&rft_id=info:pmid/11768726&rfr_iscdi=true |