Expression and prognostic value of epidermal growth factor receptor, transforming growth factor‐α, and c‐erb B‐2 in nephroblastoma

BACKGROUND Wilms tumor is one of the most common solid tumors in children. A transforming growth factor‐α (TGF‐α)/epidermal growth factor receptor (EGF‐R) autocrine loop plays an important role in tumor growth. Abnormal expression of TGF‐α, EGF‐R and c‐erb B‐2 has been demonstrated in several human...

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Veröffentlicht in:	Cancer 2001-12, Vol.92 (12), p.3120-3129
Hauptverfasser:	Ghanem, Mazen A., Van Der Kwast, Theodorus H., Den Hollander, Jan C., Sudaryo, Mondastri K., Mathoera, Rejiv B., Van den Heuvel, Marry M., Noordzij, Marinus A., Nijman, Rien J. M., van Steenbrugge, Gert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - analysis c-erbB-2 gene Child Child, Preschool c‐erb B‐2 Disease Progression epidermal growth factor receptor (EGF‐R) ErbB Receptors - analysis ErbB Receptors - biosynthesis Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Male Medical sciences Neoplasm Recurrence, Local nephroblastoma Nephrology. Urinary tract diseases Prognosis Receptor, ErbB-2 - analysis Receptor, ErbB-2 - biosynthesis Risk Factors Transforming Growth Factor beta - analysis Transforming Growth Factor beta - biosynthesis transforming growth factor‐α (TGF‐α) Tumors of the urinary system Wilms Wilms Tumor - genetics Wilms Tumor - pathology Wilms' tumor
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