Onset of Sex Differentiation: Dialog Between Genes and Cells
During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existenc...
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| Veröffentlicht in: | Archives of Medical Research 2001-11, Vol.32 (6), p.553-558 |
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| creator | Merchant-Larios, Horacio Moreno-Mendoza, Norma |
| description | During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existence of a testis-determining factor (TDF), elucidated in 1990 and named
SRY for humans and
Sry for mice. Thereafter, an increasing list of genes expressed in the genital ridges of mouse embryos at the onset of gonad differentiation has appeared. To date, it is clear that complete understanding of the mechanisms underlying gonadal sex differentiation in mammals requires identification of key cell lineages in which gonadal-specific genes are expressed. Here, a correlation between known gene expression and gonadal morphologic changes is attempted. |
| doi_str_mv | 10.1016/S0188-4409(01)00317-4 |
| format | Article |
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SRY for humans and
Sry for mice. Thereafter, an increasing list of genes expressed in the genital ridges of mouse embryos at the onset of gonad differentiation has appeared. To date, it is clear that complete understanding of the mechanisms underlying gonadal sex differentiation in mammals requires identification of key cell lineages in which gonadal-specific genes are expressed. Here, a correlation between known gene expression and gonadal morphologic changes is attempted.</description><identifier>ISSN: 0188-4409</identifier><identifier>EISSN: 1873-5487</identifier><identifier>DOI: 10.1016/S0188-4409(01)00317-4</identifier><identifier>PMID: 11750730</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Castration ; Cell Differentiation ; Cell Lineage ; Cell Movement ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Female ; Fetal Proteins - physiology ; Gene expression ; Gene Expression Regulation, Developmental ; Genes, sry ; Germ Cells - cytology ; Gonads ; Homeodomain Proteins - physiology ; Humans ; Kruppel-Like Transcription Factors ; Leydig Cells - cytology ; Male ; Mammals - physiology ; Mice ; Mice, Knockout ; Models, Biological ; Mullerian Ducts - cytology ; Mullerian Ducts - embryology ; Nuclear Proteins ; Organogenesis ; Ovary - cytology ; Ovary - embryology ; Phenotype ; Proto-Oncogene Proteins c-kit - physiology ; Seminiferous Epithelium - cytology ; Sertoli cells ; Sertoli Cells - cytology ; Sex Determination Processes ; Sex differentiation ; Sex Differentiation - genetics ; Sex Differentiation - physiology ; Sex-Determining Region Y Protein ; Stem Cell Factor - physiology ; Stromal Cells - physiology ; Testis - cytology ; Testis - embryology ; Testis - physiology ; Transcription Factors ; Wolffian Ducts - cytology ; Wolffian Ducts - embryology ; Y Chromosome - genetics</subject><ispartof>Archives of Medical Research, 2001-11, Vol.32 (6), p.553-558</ispartof><rights>2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0188-4409(01)00317-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,777,781,789,3537,27903,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11750730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merchant-Larios, Horacio</creatorcontrib><creatorcontrib>Moreno-Mendoza, Norma</creatorcontrib><title>Onset of Sex Differentiation: Dialog Between Genes and Cells</title><title>Archives of Medical Research</title><addtitle>Arch Med Res</addtitle><description>During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existence of a testis-determining factor (TDF), elucidated in 1990 and named
SRY for humans and
Sry for mice. Thereafter, an increasing list of genes expressed in the genital ridges of mouse embryos at the onset of gonad differentiation has appeared. To date, it is clear that complete understanding of the mechanisms underlying gonadal sex differentiation in mammals requires identification of key cell lineages in which gonadal-specific genes are expressed. Here, a correlation between known gene expression and gonadal morphologic changes is attempted.</description><subject>Animals</subject><subject>Castration</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Cell Movement</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Female</subject><subject>Fetal Proteins - physiology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, sry</subject><subject>Germ Cells - cytology</subject><subject>Gonads</subject><subject>Homeodomain Proteins - physiology</subject><subject>Humans</subject><subject>Kruppel-Like Transcription Factors</subject><subject>Leydig Cells - cytology</subject><subject>Male</subject><subject>Mammals - physiology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Models, Biological</subject><subject>Mullerian Ducts - cytology</subject><subject>Mullerian Ducts - embryology</subject><subject>Nuclear Proteins</subject><subject>Organogenesis</subject><subject>Ovary - cytology</subject><subject>Ovary - embryology</subject><subject>Phenotype</subject><subject>Proto-Oncogene Proteins c-kit - physiology</subject><subject>Seminiferous Epithelium - cytology</subject><subject>Sertoli cells</subject><subject>Sertoli Cells - cytology</subject><subject>Sex Determination Processes</subject><subject>Sex differentiation</subject><subject>Sex Differentiation - genetics</subject><subject>Sex Differentiation - physiology</subject><subject>Sex-Determining Region Y Protein</subject><subject>Stem Cell Factor - physiology</subject><subject>Stromal Cells - physiology</subject><subject>Testis - cytology</subject><subject>Testis - embryology</subject><subject>Testis - physiology</subject><subject>Transcription Factors</subject><subject>Wolffian Ducts - cytology</subject><subject>Wolffian Ducts - embryology</subject><subject>Y Chromosome - genetics</subject><issn>0188-4409</issn><issn>1873-5487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKw0AQQBdRbK1-gpIn0Yfo7CV7EUG0ahUKfag-L9tkIivppmZTL39vetGngeEwnDmEHFO4oEDl5RSo1qkQYM6AngNwqlKxQ_pUK55mQqtd0v9HeuQgxncA0EKqfdKjVGWgOPTJ9SREbJO6TKb4ndz7ssQGQ-td6-tw1S1cVb8ld9h-IYZkhAFj4kKRDLGq4iHZK10V8Wg7B-T18eFl-JSOJ6Pn4e04RSZ5m2pGFdUUnCgkU5lkQnCmmEYjBac5K4xRUnR2asbKEgwoCUYW4MCgc3zGB-R0c3fR1B9LjK2d-5h3Bi5gvYxWMa4yRk0HnmzB5WyOhV00fu6aH_v3bwfcbADsdD89NjbmHkOOhW8wb21Re0vBrgrbdWG7ymeB2nVhK_gv_xdozw</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Merchant-Larios, Horacio</creator><creator>Moreno-Mendoza, Norma</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Onset of Sex Differentiation: Dialog Between Genes and Cells</title><author>Merchant-Larios, Horacio ; Moreno-Mendoza, Norma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e263t-82171810a4d6275624432728e96431c2d997640007b2ff09076096d0a09eaa3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Castration</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Cell Movement</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Female</topic><topic>Fetal Proteins - physiology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, sry</topic><topic>Germ Cells - cytology</topic><topic>Gonads</topic><topic>Homeodomain Proteins - physiology</topic><topic>Humans</topic><topic>Kruppel-Like Transcription Factors</topic><topic>Leydig Cells - cytology</topic><topic>Male</topic><topic>Mammals - physiology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Models, Biological</topic><topic>Mullerian Ducts - cytology</topic><topic>Mullerian Ducts - embryology</topic><topic>Nuclear Proteins</topic><topic>Organogenesis</topic><topic>Ovary - cytology</topic><topic>Ovary - embryology</topic><topic>Phenotype</topic><topic>Proto-Oncogene Proteins c-kit - physiology</topic><topic>Seminiferous Epithelium - cytology</topic><topic>Sertoli cells</topic><topic>Sertoli Cells - cytology</topic><topic>Sex Determination Processes</topic><topic>Sex differentiation</topic><topic>Sex Differentiation - genetics</topic><topic>Sex Differentiation - physiology</topic><topic>Sex-Determining Region Y Protein</topic><topic>Stem Cell Factor - physiology</topic><topic>Stromal Cells - physiology</topic><topic>Testis - cytology</topic><topic>Testis - embryology</topic><topic>Testis - physiology</topic><topic>Transcription Factors</topic><topic>Wolffian Ducts - cytology</topic><topic>Wolffian Ducts - embryology</topic><topic>Y Chromosome - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merchant-Larios, Horacio</creatorcontrib><creatorcontrib>Moreno-Mendoza, Norma</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Medical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merchant-Larios, Horacio</au><au>Moreno-Mendoza, Norma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Onset of Sex Differentiation: Dialog Between Genes and Cells</atitle><jtitle>Archives of Medical Research</jtitle><addtitle>Arch Med Res</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>32</volume><issue>6</issue><spage>553</spage><epage>558</epage><pages>553-558</pages><issn>0188-4409</issn><eissn>1873-5487</eissn><abstract>During the late 1940s, Alfred Jost demonstrated that mammalian sex differentiation begins in fetal testis, producing two factors necessary for the establishment of phenotypic males. Castrated embryos prior to testis differentiation led to phenotypic female differentiation. Jost proposed the existence of a testis-determining factor (TDF), elucidated in 1990 and named
SRY for humans and
Sry for mice. Thereafter, an increasing list of genes expressed in the genital ridges of mouse embryos at the onset of gonad differentiation has appeared. To date, it is clear that complete understanding of the mechanisms underlying gonadal sex differentiation in mammals requires identification of key cell lineages in which gonadal-specific genes are expressed. Here, a correlation between known gene expression and gonadal morphologic changes is attempted.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11750730</pmid><doi>10.1016/S0188-4409(01)00317-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Castration Cell Differentiation Cell Lineage Cell Movement DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Female Fetal Proteins - physiology Gene expression Gene Expression Regulation, Developmental Genes, sry Germ Cells - cytology Gonads Homeodomain Proteins - physiology Humans Kruppel-Like Transcription Factors Leydig Cells - cytology Male Mammals - physiology Mice Mice, Knockout Models, Biological Mullerian Ducts - cytology Mullerian Ducts - embryology Nuclear Proteins Organogenesis Ovary - cytology Ovary - embryology Phenotype Proto-Oncogene Proteins c-kit - physiology Seminiferous Epithelium - cytology Sertoli cells Sertoli Cells - cytology Sex Determination Processes Sex differentiation Sex Differentiation - genetics Sex Differentiation - physiology Sex-Determining Region Y Protein Stem Cell Factor - physiology Stromal Cells - physiology Testis - cytology Testis - embryology Testis - physiology Transcription Factors Wolffian Ducts - cytology Wolffian Ducts - embryology Y Chromosome - genetics |
| title | Onset of Sex Differentiation: Dialog Between Genes and Cells |
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