Serotonin 1A Receptors, Serotonin Transporter Binding and Serotonin Transporter mRNA Expression in the Brainstem of Depressed Suicide Victims

Suicide and depression are associated with reduced serotonergic neurotransmission. In suicides, there is a reduction in serotonin transporter (SERT) sites and an increase in postsynaptic 5-HT1A receptors in localized regions of the prefrontal cortex. In depression, there is a diffuse decrease in SER...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2001-12, Vol.25 (6), p.892-903
Hauptverfasser:	Arango, Victoria, Underwood, Mark D, Boldrini, Maura, Tamir, Hadassah, Kassir, Suham A, Hsiung, Shu-chi, Chen, Jason J.-X, Mann, J.John
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Adult Adult and adolescent clinical studies Aged Aged, 80 and over Autoradiography Biological and medical sciences Brain Stem - metabolism Carrier Proteins - biosynthesis Carrier Proteins - metabolism Depression Depressive Disorder - metabolism Dorsal raphe nucleus Female Gene expression Humans Hydrogen-Ion Concentration Imipramine - analogs & derivatives In Situ Hybridization Male Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - metabolism Membrane Transport Proteins Mental depression Middle Aged Mood disorders Nerve Tissue Proteins Neurons Neurosciences Postmortem Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Raphe Nuclei - drug effects Raphe Nuclei - metabolism Receptor autoradiography Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT1 RNA, Messenger - biosynthesis Serotonin Serotonin Antagonists Serotonin Plasma Membrane Transport Proteins Serotonin Receptor Agonists - pharmacology Sex Characteristics Suicide Suicides & suicide attempts
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