Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair
Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared with mechanical properties tailored for use in articular cartilage repair. Compression testing was performed to investigate the influence of physiological testing conditions, manufacturing method...
Gespeichert in:
| Veröffentlicht in: | Tissue engineering 2001-12, Vol.7 (6), p.767-780 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 780 |
|---|---|
| container_issue | 6 |
| container_start_page | 767 |
| container_title | Tissue engineering |
| container_volume | 7 |
| creator | Slivka, Michael A. Leatherbury, Neil C. Kieswetter, Kris Niederauer, Gabriele G. |
| description | Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared with mechanical properties tailored for use in articular cartilage repair. Compression testing was
performed to investigate the influence of physiological testing conditions, manufacturing method, anisotropic properties due to predominant fiber orientation, amounts of fiber reinforcement (0 to 20 wt,
%), and viscoelasticity via a range of strain rates. Using the same testing modality, the mechanical properties of the scaffolds were compared with pig and goat articular cartilage. Results showed that
mechanical properties of the scaffolds under physiological conditions (aqueous, 37°C) were much lower than when tested under ambient conditions. The manufacturing method and anisotropy of the scaffolds
significantly influenced the mechanical properties. The compressive modulus and yield strength proportionally increased with increasing fiber reinforcement up to 20%. From 0.01 to 10 mm/mm/min strain rate,
the compressive modulus increased in a logarithmic fashion, and the yield strength increased in a semi-log fashion. The compressive modulus of the non-reinforced scaffolds was most similar to the pig and
goat articular cartilage when compared using similar testing conditions and modality, but the improvement in yield strength using the stiffer scaffolds with fiber reinforcement could provide needed structural
support for
in vivo
loads. |
| doi_str_mv | 10.1089/107632701753337717 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72372954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1149847671</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-dccb08e90b0a98ec6c04a002f5c6af988ac0640e6b34f33de9423dad7ca934143</originalsourceid><addsrcrecordid>eNqNkc1LHEEQxZsQ0fXjH_AQhhw87Wj11_T0cVlcFYSImlyHmp6aMNI7veneOfjf27ILAXMwpype_d6D4jF2zuGSQ22vOJhKCgPcaCmlMdx8YTOutSnrysLXvGegzIQ9YscpvQCA1twcsiPOjbJGyhn79RBimNK8eKQUYoutp3mxGlqK5SMNYx-io654ctj3wXepeMbBh5ilfCkWcTu4yWMslphXj78p52xwiKfsoEef6Gw_T9jP1fXz8ra8_3Fzt1zcl04ZsS0751qoyUILaGtylQOFAKLXrsLe1jU6qBRQ1UrVS9mRVUJ22BmHViqu5Am72OVuYvgzUdo26yE58h5Hym81RkgjrP4c5LXUWlmRwe8fwJcwxTE_0QiuKy61tBkSO8jFkFKkvtnEYY3xteHQvHfT_NtNNn3bJ0_tmrq_ln0ZGah3wLuM4-gHyj1s_yf7DRfzmbU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215613539</pqid></control><display><type>article</type><title>Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><creator>Slivka, Michael A. ; Leatherbury, Neil C. ; Kieswetter, Kris ; Niederauer, Gabriele G.</creator><creatorcontrib>Slivka, Michael A. ; Leatherbury, Neil C. ; Kieswetter, Kris ; Niederauer, Gabriele G.</creatorcontrib><description>Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared with mechanical properties tailored for use in articular cartilage repair. Compression testing was
performed to investigate the influence of physiological testing conditions, manufacturing method, anisotropic properties due to predominant fiber orientation, amounts of fiber reinforcement (0 to 20 wt,
%), and viscoelasticity via a range of strain rates. Using the same testing modality, the mechanical properties of the scaffolds were compared with pig and goat articular cartilage. Results showed that
mechanical properties of the scaffolds under physiological conditions (aqueous, 37°C) were much lower than when tested under ambient conditions. The manufacturing method and anisotropy of the scaffolds
significantly influenced the mechanical properties. The compressive modulus and yield strength proportionally increased with increasing fiber reinforcement up to 20%. From 0.01 to 10 mm/mm/min strain rate,
the compressive modulus increased in a logarithmic fashion, and the yield strength increased in a semi-log fashion. The compressive modulus of the non-reinforced scaffolds was most similar to the pig and
goat articular cartilage when compared using similar testing conditions and modality, but the improvement in yield strength using the stiffer scaffolds with fiber reinforcement could provide needed structural
support for
in vivo
loads.</description><identifier>ISSN: 1076-3279</identifier><identifier>EISSN: 1557-8690</identifier><identifier>DOI: 10.1089/107632701753337717</identifier><identifier>PMID: 11749733</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Biocompatible Materials ; Cartilage, Articular - physiology ; Extracellular Matrix - physiology ; Goats ; Lactic Acid ; Original Articles ; poly(D,L-lactide-co-glycolide) ; poly(lactide-co-glycolide) ; Polyglycolic Acid ; Polymers ; Prosthesis Design ; Regeneration ; Stress, Mechanical ; Swine ; Tissue Engineering</subject><ispartof>Tissue engineering, 2001-12, Vol.7 (6), p.767-780</ispartof><rights>Copyright Mary Ann Liebert Inc. Dec 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-dccb08e90b0a98ec6c04a002f5c6af988ac0640e6b34f33de9423dad7ca934143</citedby><cites>FETCH-LOGICAL-c472t-dccb08e90b0a98ec6c04a002f5c6af988ac0640e6b34f33de9423dad7ca934143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/107632701753337717$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/107632701753337717$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,780,784,3042,21723,27924,27925,55291,55303</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11749733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slivka, Michael A.</creatorcontrib><creatorcontrib>Leatherbury, Neil C.</creatorcontrib><creatorcontrib>Kieswetter, Kris</creatorcontrib><creatorcontrib>Niederauer, Gabriele G.</creatorcontrib><title>Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair</title><title>Tissue engineering</title><addtitle>Tissue Eng</addtitle><description>Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared with mechanical properties tailored for use in articular cartilage repair. Compression testing was
performed to investigate the influence of physiological testing conditions, manufacturing method, anisotropic properties due to predominant fiber orientation, amounts of fiber reinforcement (0 to 20 wt,
%), and viscoelasticity via a range of strain rates. Using the same testing modality, the mechanical properties of the scaffolds were compared with pig and goat articular cartilage. Results showed that
mechanical properties of the scaffolds under physiological conditions (aqueous, 37°C) were much lower than when tested under ambient conditions. The manufacturing method and anisotropy of the scaffolds
significantly influenced the mechanical properties. The compressive modulus and yield strength proportionally increased with increasing fiber reinforcement up to 20%. From 0.01 to 10 mm/mm/min strain rate,
the compressive modulus increased in a logarithmic fashion, and the yield strength increased in a semi-log fashion. The compressive modulus of the non-reinforced scaffolds was most similar to the pig and
goat articular cartilage when compared using similar testing conditions and modality, but the improvement in yield strength using the stiffer scaffolds with fiber reinforcement could provide needed structural
support for
in vivo
loads.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Cartilage, Articular - physiology</subject><subject>Extracellular Matrix - physiology</subject><subject>Goats</subject><subject>Lactic Acid</subject><subject>Original Articles</subject><subject>poly(D,L-lactide-co-glycolide)</subject><subject>poly(lactide-co-glycolide)</subject><subject>Polyglycolic Acid</subject><subject>Polymers</subject><subject>Prosthesis Design</subject><subject>Regeneration</subject><subject>Stress, Mechanical</subject><subject>Swine</subject><subject>Tissue Engineering</subject><issn>1076-3279</issn><issn>1557-8690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1LHEEQxZsQ0fXjH_AQhhw87Wj11_T0cVlcFYSImlyHmp6aMNI7veneOfjf27ILAXMwpype_d6D4jF2zuGSQ22vOJhKCgPcaCmlMdx8YTOutSnrysLXvGegzIQ9YscpvQCA1twcsiPOjbJGyhn79RBimNK8eKQUYoutp3mxGlqK5SMNYx-io654ctj3wXepeMbBh5ilfCkWcTu4yWMslphXj78p52xwiKfsoEef6Gw_T9jP1fXz8ra8_3Fzt1zcl04ZsS0751qoyUILaGtylQOFAKLXrsLe1jU6qBRQ1UrVS9mRVUJ22BmHViqu5Am72OVuYvgzUdo26yE58h5Hym81RkgjrP4c5LXUWlmRwe8fwJcwxTE_0QiuKy61tBkSO8jFkFKkvtnEYY3xteHQvHfT_NtNNn3bJ0_tmrq_ln0ZGah3wLuM4-gHyj1s_yf7DRfzmbU</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Slivka, Michael A.</creator><creator>Leatherbury, Neil C.</creator><creator>Kieswetter, Kris</creator><creator>Niederauer, Gabriele G.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair</title><author>Slivka, Michael A. ; Leatherbury, Neil C. ; Kieswetter, Kris ; Niederauer, Gabriele G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-dccb08e90b0a98ec6c04a002f5c6af988ac0640e6b34f33de9423dad7ca934143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Cartilage, Articular - physiology</topic><topic>Extracellular Matrix - physiology</topic><topic>Goats</topic><topic>Lactic Acid</topic><topic>Original Articles</topic><topic>poly(D,L-lactide-co-glycolide)</topic><topic>poly(lactide-co-glycolide)</topic><topic>Polyglycolic Acid</topic><topic>Polymers</topic><topic>Prosthesis Design</topic><topic>Regeneration</topic><topic>Stress, Mechanical</topic><topic>Swine</topic><topic>Tissue Engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slivka, Michael A.</creatorcontrib><creatorcontrib>Leatherbury, Neil C.</creatorcontrib><creatorcontrib>Kieswetter, Kris</creatorcontrib><creatorcontrib>Niederauer, Gabriele G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slivka, Michael A.</au><au>Leatherbury, Neil C.</au><au>Kieswetter, Kris</au><au>Niederauer, Gabriele G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair</atitle><jtitle>Tissue engineering</jtitle><addtitle>Tissue Eng</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>7</volume><issue>6</issue><spage>767</spage><epage>780</epage><pages>767-780</pages><issn>1076-3279</issn><eissn>1557-8690</eissn><abstract>Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared with mechanical properties tailored for use in articular cartilage repair. Compression testing was
performed to investigate the influence of physiological testing conditions, manufacturing method, anisotropic properties due to predominant fiber orientation, amounts of fiber reinforcement (0 to 20 wt,
%), and viscoelasticity via a range of strain rates. Using the same testing modality, the mechanical properties of the scaffolds were compared with pig and goat articular cartilage. Results showed that
mechanical properties of the scaffolds under physiological conditions (aqueous, 37°C) were much lower than when tested under ambient conditions. The manufacturing method and anisotropy of the scaffolds
significantly influenced the mechanical properties. The compressive modulus and yield strength proportionally increased with increasing fiber reinforcement up to 20%. From 0.01 to 10 mm/mm/min strain rate,
the compressive modulus increased in a logarithmic fashion, and the yield strength increased in a semi-log fashion. The compressive modulus of the non-reinforced scaffolds was most similar to the pig and
goat articular cartilage when compared using similar testing conditions and modality, but the improvement in yield strength using the stiffer scaffolds with fiber reinforcement could provide needed structural
support for
in vivo
loads.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>11749733</pmid><doi>10.1089/107632701753337717</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1076-3279 |
| ispartof | Tissue engineering, 2001-12, Vol.7 (6), p.767-780 |
| issn | 1076-3279 1557-8690 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72372954 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Animals Biocompatible Materials Cartilage, Articular - physiology Extracellular Matrix - physiology Goats Lactic Acid Original Articles poly(D,L-lactide-co-glycolide) poly(lactide-co-glycolide) Polyglycolic Acid Polymers Prosthesis Design Regeneration Stress, Mechanical Swine Tissue Engineering |
| title | Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A49%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Porous,%20Resorbable,%20Fiber-Reinforced%20Scaffolds%20Tailored%20for%20Articular%20Cartilage%20Repair&rft.jtitle=Tissue%20engineering&rft.au=Slivka,%20Michael%20A.&rft.date=2001-12-01&rft.volume=7&rft.issue=6&rft.spage=767&rft.epage=780&rft.pages=767-780&rft.issn=1076-3279&rft.eissn=1557-8690&rft_id=info:doi/10.1089/107632701753337717&rft_dat=%3Cproquest_cross%3E1149847671%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=215613539&rft_id=info:pmid/11749733&rfr_iscdi=true |