Elongated Multiple Electronic Cascade and Cyclization Spacer Systems in Activatible Anticancer Prodrugs for Enhanced Drug Release

The design and synthesis of several novel elongated self-elimination spacer systems for application in prodrugs is described. These elongated spacer systems can be incorporated between a cleavable specifier and the parent drug. Naphthalene- and biphenyl-containing spacers were synthesized but did no...

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Veröffentlicht in:	Journal of organic chemistry 2001-12, Vol.66 (26), p.8815-8830
Hauptverfasser:	de Groot, Franciscus M. H, Loos, Walter J, Koekkoek, Ralph, van Berkom, Leon W. A, Busscher, Guuske F, Seelen, Antoinette E, Albrecht, Carsten, de Bruijn, Peter, Scheeren, Hans W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Carbamates - chemistry Cyclization Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Screening Assays, Antitumor Electrons Fibrinolysin - chemistry Humans Hydrolysis Indicators and Reagents Kinetics Oligopeptides - chemistry Paclitaxel - administration & dosage Paclitaxel - chemistry Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - pharmacology Structure-Activity Relationship Tumor Cells, Cultured
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