Computerized system for outcomes-based antiemetic therapy in children
OBJECTIVE: To introduce a computerized data collection system used for an outcomes-based approach to antiemetic therapy in children, and to present data collected with this system in support of a new antiemetic dosing regimen. METHODS: A validated nausea/vomiting survey was used to collect data on n...
Gespeichert in:
| Veröffentlicht in: | The Annals of pharmacotherapy 2000-10, Vol.34 (10), p.1101-1108 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1108 |
|---|---|
| container_issue | 10 |
| container_start_page | 1101 |
| container_title | The Annals of pharmacotherapy |
| container_volume | 34 |
| creator | Holdsworth, MT Adams, VR Raisch, DW Wood, JG Winter, SS |
| description | OBJECTIVE:
To introduce a computerized data collection system used for an outcomes-based approach to antiemetic therapy in children, and to present data collected with this system in support of a new antiemetic dosing regimen.
METHODS:
A validated nausea/vomiting survey was used to collect data on nausea severity (NSEV), vomiting severity (VSEV), daily activity interference (DAI), and the number of vomiting episodes. NSEV, VSEV, and DAI were rated as 0 = none to 3 = severe. All children and/or their parents were surveyed following the completion of each highly emetogenic chemotherapy regimen. This survey was computerized and transferred to a handheld data entry unit. Time and motion studies were performed to compare the time required to collect nausea/vomiting data and transfer the data to a computerized database with the handheld system versus traditional paper (manual) surveys. The handheld technology was used to collect survey data for children receiving a new antiemetic regimen (daily ondansetron and dexamethasone [OD]), which was then compared with data obtained with a previously employed regimen (thrice-daily ondansetron and daily methylprednisolone [OM]). Statistical analysis and a cost-effectiveness analysis (CEA) were performed to compare the two antiemetic regimens.
RESULTS:
The mean time required for total data entry with the manual system was 5.2 minutes per survey versus 2.4 minutes with the handheld technology (p = 0.0026). A total of 376 nausea/vomiting surveys in 78 children receiving the OM antiemetic regimen were compared with 153 surveys in 38 children treated with the OD regimen. The mean survey scores were as follows: NSEV (1.2 vs. 0.8), VSEV (1.0 vs. 0.7), DAI (1.0 vs. 0.7), and number of vomiting episodes (4.3 vs. 2.1) for OM and OD, respectively; all were significantly lower with the OD regimen (p < 0.05). The percentage of patients with complete control of nausea and vomiting (19.2% vs. 39.2%) and good control (55.6% vs. 65.4%) were significantly greater with the OD regimen (p < 0.05). The CEA revealed that the OD resulted in a reduction of approximately $31 per patient for good protection and a $258 reduction for complete protection from nausea and vomiting.
CONCLUSIONS:
A computerized outcomes-based system aided by handheld technology allowed for more prompt and efficient collection of nausea/vomiting data. The OD antiemetic regimen was shown to be a more cost-effective alternative for children receiving severely emetogenic chemo |
| doi_str_mv | 10.1345/aph.19410 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72370052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1345_aph.19410</sage_id><sourcerecordid>72370052</sourcerecordid><originalsourceid>FETCH-LOGICAL-c373t-7aeed14530da0c00b8718d3f816e6ab1e2f05b628b55dda2998442ce9f4643e83</originalsourceid><addsrcrecordid>eNptkEtLw0AQxxdRrFYPfgHJQRQPqbOvPI5S6gMKXvS8bDaTZkte7iaU-umNbaEXTzMwv_nP8CPkhsKMciGfdFfOaCoonJALKgULIxbD6dhDBCGwBCbk0vs1AKSUpedkQilIkcbigizmbd0NPTr7g3ngt77HOihaF7RDb9oafZhpP05001ussbcm6Et0utsGtglMaavcYXNFzgpdebw-1Cn5ell8zt_C5cfr-_x5GRoe8z6MNWJOheSQazAAWRLTJOdFQiOMdEaRFSCziCWZlHmuWZomQjCDaSEiwTHhU3K_z-1c-z2g71VtvcGq0g22g1cx4zGAZCP4uAeNa713WKjO2Vq7raKg_pyp0ZnaORvZ20PokNWYH8mDpBG4OwDaG10VTjfG-iMnWcR5enzO6xWqdTu4ZnTx78GHPVjaVbmxDpWvdVWN56nabDZc7HYoUP4LKRuNlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72370052</pqid></control><display><type>article</type><title>Computerized system for outcomes-based antiemetic therapy in children</title><source>MEDLINE</source><source>SAGE Journals</source><creator>Holdsworth, MT ; Adams, VR ; Raisch, DW ; Wood, JG ; Winter, SS</creator><creatorcontrib>Holdsworth, MT ; Adams, VR ; Raisch, DW ; Wood, JG ; Winter, SS</creatorcontrib><description>OBJECTIVE:
To introduce a computerized data collection system used for an outcomes-based approach to antiemetic therapy in children, and to present data collected with this system in support of a new antiemetic dosing regimen.
METHODS:
A validated nausea/vomiting survey was used to collect data on nausea severity (NSEV), vomiting severity (VSEV), daily activity interference (DAI), and the number of vomiting episodes. NSEV, VSEV, and DAI were rated as 0 = none to 3 = severe. All children and/or their parents were surveyed following the completion of each highly emetogenic chemotherapy regimen. This survey was computerized and transferred to a handheld data entry unit. Time and motion studies were performed to compare the time required to collect nausea/vomiting data and transfer the data to a computerized database with the handheld system versus traditional paper (manual) surveys. The handheld technology was used to collect survey data for children receiving a new antiemetic regimen (daily ondansetron and dexamethasone [OD]), which was then compared with data obtained with a previously employed regimen (thrice-daily ondansetron and daily methylprednisolone [OM]). Statistical analysis and a cost-effectiveness analysis (CEA) were performed to compare the two antiemetic regimens.
RESULTS:
The mean time required for total data entry with the manual system was 5.2 minutes per survey versus 2.4 minutes with the handheld technology (p = 0.0026). A total of 376 nausea/vomiting surveys in 78 children receiving the OM antiemetic regimen were compared with 153 surveys in 38 children treated with the OD regimen. The mean survey scores were as follows: NSEV (1.2 vs. 0.8), VSEV (1.0 vs. 0.7), DAI (1.0 vs. 0.7), and number of vomiting episodes (4.3 vs. 2.1) for OM and OD, respectively; all were significantly lower with the OD regimen (p < 0.05). The percentage of patients with complete control of nausea and vomiting (19.2% vs. 39.2%) and good control (55.6% vs. 65.4%) were significantly greater with the OD regimen (p < 0.05). The CEA revealed that the OD resulted in a reduction of approximately $31 per patient for good protection and a $258 reduction for complete protection from nausea and vomiting.
CONCLUSIONS:
A computerized outcomes-based system aided by handheld technology allowed for more prompt and efficient collection of nausea/vomiting data. The OD antiemetic regimen was shown to be a more cost-effective alternative for children receiving severely emetogenic chemotherapy.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1345/aph.19410</identifier><identifier>PMID: 11054974</identifier><identifier>CODEN: APHRER</identifier><language>eng</language><publisher>Cincinnati, OH: Harvey Whitney Books</publisher><subject>Antiemetics - administration & dosage ; Antiemetics - economics ; Antiemetics - therapeutic use ; Biological and medical sciences ; Child ; Cost-Benefit Analysis ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Male ; Medical sciences ; Nausea - drug therapy ; Odds Ratio ; Ondansetron - administration & dosage ; Ondansetron - therapeutic use ; Pharmacology. Drug treatments ; Time and Motion Studies ; Toxicity: digestive system ; Treatment Outcome ; Vomiting - drug therapy ; Vomiting - economics</subject><ispartof>The Annals of pharmacotherapy, 2000-10, Vol.34 (10), p.1101-1108</ispartof><rights>2000 SAGE Publications</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-7aeed14530da0c00b8718d3f816e6ab1e2f05b628b55dda2998442ce9f4643e83</citedby><cites>FETCH-LOGICAL-c373t-7aeed14530da0c00b8718d3f816e6ab1e2f05b628b55dda2998442ce9f4643e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1345/aph.19410$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1345/aph.19410$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1526339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11054974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holdsworth, MT</creatorcontrib><creatorcontrib>Adams, VR</creatorcontrib><creatorcontrib>Raisch, DW</creatorcontrib><creatorcontrib>Wood, JG</creatorcontrib><creatorcontrib>Winter, SS</creatorcontrib><title>Computerized system for outcomes-based antiemetic therapy in children</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>OBJECTIVE:
To introduce a computerized data collection system used for an outcomes-based approach to antiemetic therapy in children, and to present data collected with this system in support of a new antiemetic dosing regimen.
METHODS:
A validated nausea/vomiting survey was used to collect data on nausea severity (NSEV), vomiting severity (VSEV), daily activity interference (DAI), and the number of vomiting episodes. NSEV, VSEV, and DAI were rated as 0 = none to 3 = severe. All children and/or their parents were surveyed following the completion of each highly emetogenic chemotherapy regimen. This survey was computerized and transferred to a handheld data entry unit. Time and motion studies were performed to compare the time required to collect nausea/vomiting data and transfer the data to a computerized database with the handheld system versus traditional paper (manual) surveys. The handheld technology was used to collect survey data for children receiving a new antiemetic regimen (daily ondansetron and dexamethasone [OD]), which was then compared with data obtained with a previously employed regimen (thrice-daily ondansetron and daily methylprednisolone [OM]). Statistical analysis and a cost-effectiveness analysis (CEA) were performed to compare the two antiemetic regimens.
RESULTS:
The mean time required for total data entry with the manual system was 5.2 minutes per survey versus 2.4 minutes with the handheld technology (p = 0.0026). A total of 376 nausea/vomiting surveys in 78 children receiving the OM antiemetic regimen were compared with 153 surveys in 38 children treated with the OD regimen. The mean survey scores were as follows: NSEV (1.2 vs. 0.8), VSEV (1.0 vs. 0.7), DAI (1.0 vs. 0.7), and number of vomiting episodes (4.3 vs. 2.1) for OM and OD, respectively; all were significantly lower with the OD regimen (p < 0.05). The percentage of patients with complete control of nausea and vomiting (19.2% vs. 39.2%) and good control (55.6% vs. 65.4%) were significantly greater with the OD regimen (p < 0.05). The CEA revealed that the OD resulted in a reduction of approximately $31 per patient for good protection and a $258 reduction for complete protection from nausea and vomiting.
CONCLUSIONS:
A computerized outcomes-based system aided by handheld technology allowed for more prompt and efficient collection of nausea/vomiting data. The OD antiemetic regimen was shown to be a more cost-effective alternative for children receiving severely emetogenic chemotherapy.</description><subject>Antiemetics - administration & dosage</subject><subject>Antiemetics - economics</subject><subject>Antiemetics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cost-Benefit Analysis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nausea - drug therapy</subject><subject>Odds Ratio</subject><subject>Ondansetron - administration & dosage</subject><subject>Ondansetron - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Time and Motion Studies</subject><subject>Toxicity: digestive system</subject><subject>Treatment Outcome</subject><subject>Vomiting - drug therapy</subject><subject>Vomiting - economics</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLw0AQxxdRrFYPfgHJQRQPqbOvPI5S6gMKXvS8bDaTZkte7iaU-umNbaEXTzMwv_nP8CPkhsKMciGfdFfOaCoonJALKgULIxbD6dhDBCGwBCbk0vs1AKSUpedkQilIkcbigizmbd0NPTr7g3ngt77HOihaF7RDb9oafZhpP05001ussbcm6Et0utsGtglMaavcYXNFzgpdebw-1Cn5ell8zt_C5cfr-_x5GRoe8z6MNWJOheSQazAAWRLTJOdFQiOMdEaRFSCziCWZlHmuWZomQjCDaSEiwTHhU3K_z-1c-z2g71VtvcGq0g22g1cx4zGAZCP4uAeNa713WKjO2Vq7raKg_pyp0ZnaORvZ20PokNWYH8mDpBG4OwDaG10VTjfG-iMnWcR5enzO6xWqdTu4ZnTx78GHPVjaVbmxDpWvdVWN56nabDZc7HYoUP4LKRuNlw</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Holdsworth, MT</creator><creator>Adams, VR</creator><creator>Raisch, DW</creator><creator>Wood, JG</creator><creator>Winter, SS</creator><general>Harvey Whitney Books</general><general>SAGE Publications</general><general>Whitney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Computerized system for outcomes-based antiemetic therapy in children</title><author>Holdsworth, MT ; Adams, VR ; Raisch, DW ; Wood, JG ; Winter, SS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-7aeed14530da0c00b8718d3f816e6ab1e2f05b628b55dda2998442ce9f4643e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antiemetics - administration & dosage</topic><topic>Antiemetics - economics</topic><topic>Antiemetics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cost-Benefit Analysis</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nausea - drug therapy</topic><topic>Odds Ratio</topic><topic>Ondansetron - administration & dosage</topic><topic>Ondansetron - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Time and Motion Studies</topic><topic>Toxicity: digestive system</topic><topic>Treatment Outcome</topic><topic>Vomiting - drug therapy</topic><topic>Vomiting - economics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holdsworth, MT</creatorcontrib><creatorcontrib>Adams, VR</creatorcontrib><creatorcontrib>Raisch, DW</creatorcontrib><creatorcontrib>Wood, JG</creatorcontrib><creatorcontrib>Winter, SS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holdsworth, MT</au><au>Adams, VR</au><au>Raisch, DW</au><au>Wood, JG</au><au>Winter, SS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computerized system for outcomes-based antiemetic therapy in children</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>34</volume><issue>10</issue><spage>1101</spage><epage>1108</epage><pages>1101-1108</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><coden>APHRER</coden><abstract>OBJECTIVE:
To introduce a computerized data collection system used for an outcomes-based approach to antiemetic therapy in children, and to present data collected with this system in support of a new antiemetic dosing regimen.
METHODS:
A validated nausea/vomiting survey was used to collect data on nausea severity (NSEV), vomiting severity (VSEV), daily activity interference (DAI), and the number of vomiting episodes. NSEV, VSEV, and DAI were rated as 0 = none to 3 = severe. All children and/or their parents were surveyed following the completion of each highly emetogenic chemotherapy regimen. This survey was computerized and transferred to a handheld data entry unit. Time and motion studies were performed to compare the time required to collect nausea/vomiting data and transfer the data to a computerized database with the handheld system versus traditional paper (manual) surveys. The handheld technology was used to collect survey data for children receiving a new antiemetic regimen (daily ondansetron and dexamethasone [OD]), which was then compared with data obtained with a previously employed regimen (thrice-daily ondansetron and daily methylprednisolone [OM]). Statistical analysis and a cost-effectiveness analysis (CEA) were performed to compare the two antiemetic regimens.
RESULTS:
The mean time required for total data entry with the manual system was 5.2 minutes per survey versus 2.4 minutes with the handheld technology (p = 0.0026). A total of 376 nausea/vomiting surveys in 78 children receiving the OM antiemetic regimen were compared with 153 surveys in 38 children treated with the OD regimen. The mean survey scores were as follows: NSEV (1.2 vs. 0.8), VSEV (1.0 vs. 0.7), DAI (1.0 vs. 0.7), and number of vomiting episodes (4.3 vs. 2.1) for OM and OD, respectively; all were significantly lower with the OD regimen (p < 0.05). The percentage of patients with complete control of nausea and vomiting (19.2% vs. 39.2%) and good control (55.6% vs. 65.4%) were significantly greater with the OD regimen (p < 0.05). The CEA revealed that the OD resulted in a reduction of approximately $31 per patient for good protection and a $258 reduction for complete protection from nausea and vomiting.
CONCLUSIONS:
A computerized outcomes-based system aided by handheld technology allowed for more prompt and efficient collection of nausea/vomiting data. The OD antiemetic regimen was shown to be a more cost-effective alternative for children receiving severely emetogenic chemotherapy.</abstract><cop>Cincinnati, OH</cop><pub>Harvey Whitney Books</pub><pmid>11054974</pmid><doi>10.1345/aph.19410</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1060-0280 |
| ispartof | The Annals of pharmacotherapy, 2000-10, Vol.34 (10), p.1101-1108 |
| issn | 1060-0280 1542-6270 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72370052 |
| source | MEDLINE; SAGE Journals |
| subjects | Antiemetics - administration & dosage Antiemetics - economics Antiemetics - therapeutic use Biological and medical sciences Child Cost-Benefit Analysis Drug toxicity and drugs side effects treatment Female Humans Male Medical sciences Nausea - drug therapy Odds Ratio Ondansetron - administration & dosage Ondansetron - therapeutic use Pharmacology. Drug treatments Time and Motion Studies Toxicity: digestive system Treatment Outcome Vomiting - drug therapy Vomiting - economics |
| title | Computerized system for outcomes-based antiemetic therapy in children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A46%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Computerized%20system%20for%20outcomes-based%20antiemetic%20therapy%20in%20children&rft.jtitle=The%20Annals%20of%20pharmacotherapy&rft.au=Holdsworth,%20MT&rft.date=2000-10-01&rft.volume=34&rft.issue=10&rft.spage=1101&rft.epage=1108&rft.pages=1101-1108&rft.issn=1060-0280&rft.eissn=1542-6270&rft.coden=APHRER&rft_id=info:doi/10.1345/aph.19410&rft_dat=%3Cproquest_cross%3E72370052%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72370052&rft_id=info:pmid/11054974&rft_sage_id=10.1345_aph.19410&rfr_iscdi=true |