Excitotoxic Lesions of the Hippocampus Leave Sensory Preconditioning Intact: Implications for Models of Hippocampal Function
Learning about contextual cues is markedly disrupted in rats with hippocampal lesions. One analysis of this disruption is that it reflects a general failure to form associations between the elements of complex events. A straightforward prediction of this analysis is that sensory preconditioning will...
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| Veröffentlicht in: | Behavioral neuroscience 2001-12, Vol.115 (6), p.1357-1362 |
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| container_title | Behavioral neuroscience |
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| creator | Ward-Robinson, Jasper Coutureau, Etienne Good, Mark Honey, R. C Killcross, A. S Oswald, C. J. P |
| description | Learning about contextual cues is markedly disrupted in rats with hippocampal lesions. One analysis of this disruption is that it reflects a general failure to form associations between the elements of complex events. A straightforward prediction of this analysis is that sensory preconditioning will be disrupted by hippocampal lesions. This prediction was assessed by presenting rats with flavored solutions composed of 2 elements (A and X) before X was paired with an injection of the emetic, lithium chloride. A subsequent test revealed that rats were less willing to consume Solution A than they were to consume a control solution, B. This was true of rats with sham lesions and those with excitotoxic lesions of hippocampus. These findings fail to support the proposition that the hippocampus-dependent deficit in contextual conditioning is due to a general disruption to the process of associating the elements of complex events. |
| doi_str_mv | 10.1037/0735-7044.115.6.1357 |
| format | Article |
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P</au><au>Gallagher, Michela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excitotoxic Lesions of the Hippocampus Leave Sensory Preconditioning Intact: Implications for Models of Hippocampal Function</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2001-12</date><risdate>2001</risdate><volume>115</volume><issue>6</issue><spage>1357</spage><epage>1362</epage><pages>1357-1362</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Learning about contextual cues is markedly disrupted in rats with hippocampal lesions. One analysis of this disruption is that it reflects a general failure to form associations between the elements of complex events. A straightforward prediction of this analysis is that sensory preconditioning will be disrupted by hippocampal lesions. 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| subjects | Anatomical correlates of behavior Animal behavior Animals Behavioral psychophysiology Biological and medical sciences Brain Conditioning, Classical Discrimination Learning Fundamental and applied biological sciences. Psychology Hippocampus - pathology Hippocampus - physiology Male Maze Learning Neurology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rodents Taste |
| title | Excitotoxic Lesions of the Hippocampus Leave Sensory Preconditioning Intact: Implications for Models of Hippocampal Function |
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