Rhinovirus elicits proasthmatic changes in airway responsiveness independently of viral infection

Background: Rhinovirus (RV), the principal pathogen responsible for the common cold, is importantly implicated in triggering attacks of asthma secondary to changes in airway responsiveness. Objective: Because the airway histopathologic features of RV infection are relatively modest, we tested the hy...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2001-12, Vol.108 (6), p.997-1004
Hauptverfasser:	Grunstein, Michael M., Hakonarson, Hakon, Whelan, Russell, Yu, Zheya, Grunstein, Judith S., Chuang, Sing
Format:	Artikel
Sprache:	eng
Schlagworte:	airway reactivity Allergic diseases Animals asthma Asthma - etiology Biological and medical sciences Bronchi - pathology Bronchi - physiopathology Chronic obstructive pulmonary disease, asthma common cold Cytokines GTP-Binding Protein alpha Subunits, Gi-Go - analysis Immunopathology intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - physiology Interleukin-1 - secretion Interleukin-5 - secretion Medical sciences Muscle, Smooth - pathology Muscle, Smooth - physiopathology Picornaviridae Infections - pathology Picornaviridae Infections - physiopathology Pneumology Rabbits Respiratory and ent allergic diseases Rhinovirus Rhinovirus - physiology transmembrane signaling
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