Respiratory variability in panic disorder
Disordered breathing may play an important role in the pathophysiology of panic disorder. Several studies have now indicated that panic disorder patients have greater respiratory variability than normal controls. In this study, we examine baseline respiratory measures in four diagnostic groups to de...
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| Veröffentlicht in: | Depression and anxiety 2001, Vol.14 (4), p.232-237 |
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| creator | Martinez, J.M. Kent, J.M. Coplan, J.D. Browne, S.T. Papp, L.A. Sullivan, G.M. Kleber, M. Perepletchikova, F. Fyer, A.J. Klein, D.F. Gorman, J.M. |
| description | Disordered breathing may play an important role in the pathophysiology of panic disorder. Several studies have now indicated that panic disorder patients have greater respiratory variability than normal controls. In this study, we examine baseline respiratory measures in four diagnostic groups to determine whether greater respiratory variability is specific to panic disorder and whether effective anti‐panic treatment alters respiratory variability. Patients with panic disorder, major depression, or premenstrual dysphoric disorder, and normal control subjects underwent two respiratory exposures (5% and 7% CO2 inhalation), while in a canopy system. Panic disorder patients returned after 12 weeks of either anti‐panic medication or cognitive behavioral therapy, and were retested. Normal control subjects were also retested after a period of 12 weeks. Panic disorder patients had significantly greater respiratory variability at baseline than normal control subjects and patients with major depression. The premenstrual dysphoric patients also had greater variability than the normal control group. Panic disorder patients who panicked to 7% CO2 inhalation had significantly greater baseline variability than panic disorder patients who did not panic. Anti‐panic treatment did not significantly alter baseline respiratory variability. Our data suggest that increased respiratory variability may be an important trait feature for some panic disorder patients and may make them more vulnerable to CO2‐induced panic. Depression and Anxiety 14:232–237, 2001. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/da.1072 |
| format | Article |
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Several studies have now indicated that panic disorder patients have greater respiratory variability than normal controls. In this study, we examine baseline respiratory measures in four diagnostic groups to determine whether greater respiratory variability is specific to panic disorder and whether effective anti‐panic treatment alters respiratory variability. Patients with panic disorder, major depression, or premenstrual dysphoric disorder, and normal control subjects underwent two respiratory exposures (5% and 7% CO2 inhalation), while in a canopy system. Panic disorder patients returned after 12 weeks of either anti‐panic medication or cognitive behavioral therapy, and were retested. Normal control subjects were also retested after a period of 12 weeks. Panic disorder patients had significantly greater respiratory variability at baseline than normal control subjects and patients with major depression. The premenstrual dysphoric patients also had greater variability than the normal control group. Panic disorder patients who panicked to 7% CO2 inhalation had significantly greater baseline variability than panic disorder patients who did not panic. Anti‐panic treatment did not significantly alter baseline respiratory variability. Our data suggest that increased respiratory variability may be an important trait feature for some panic disorder patients and may make them more vulnerable to CO2‐induced panic. 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Anxiety</addtitle><description>Disordered breathing may play an important role in the pathophysiology of panic disorder. Several studies have now indicated that panic disorder patients have greater respiratory variability than normal controls. In this study, we examine baseline respiratory measures in four diagnostic groups to determine whether greater respiratory variability is specific to panic disorder and whether effective anti‐panic treatment alters respiratory variability. Patients with panic disorder, major depression, or premenstrual dysphoric disorder, and normal control subjects underwent two respiratory exposures (5% and 7% CO2 inhalation), while in a canopy system. Panic disorder patients returned after 12 weeks of either anti‐panic medication or cognitive behavioral therapy, and were retested. Normal control subjects were also retested after a period of 12 weeks. Panic disorder patients had significantly greater respiratory variability at baseline than normal control subjects and patients with major depression. The premenstrual dysphoric patients also had greater variability than the normal control group. Panic disorder patients who panicked to 7% CO2 inhalation had significantly greater baseline variability than panic disorder patients who did not panic. Anti‐panic treatment did not significantly alter baseline respiratory variability. Our data suggest that increased respiratory variability may be an important trait feature for some panic disorder patients and may make them more vulnerable to CO2‐induced panic. Depression and Anxiety 14:232–237, 2001. © 2001 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Arousal - physiology</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Carbon Dioxide</subject><subject>Cognitive Therapy</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Dose-Response Relationship, Drug</subject><subject>fear</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperventilation - diagnosis</subject><subject>Hyperventilation - physiopathology</subject><subject>Hyperventilation - psychology</subject><subject>Imipramine - administration & dosage</subject><subject>Male</subject><subject>panic disorder</subject><subject>Panic Disorder - diagnosis</subject><subject>Panic Disorder - physiopathology</subject><subject>Panic Disorder - psychology</subject><subject>Panic Disorder - therapy</subject><subject>Premenstrual Syndrome - diagnosis</subject><subject>Premenstrual Syndrome - physiopathology</subject><subject>Premenstrual Syndrome - psychology</subject><subject>Reference Values</subject><subject>respiration</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>trait</subject><subject>variability</subject><issn>1091-4269</issn><issn>1520-6394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0FtLwzAYBuAgiptT_AeyK0WkmnPbyzl1k3lA8XAZ0iSFaLfWpFP7781o0SvR3HzfxfO9hBeAXQSPEYT4RMswY7wG-ohhGHGS0vWwwxRFFPO0B7a8f4EQJmkCN0EPoZhRRFAfHN4bX1kn69I1w3fprMxsYetmaBfDSi6sGmrrS6eN2wYbuSy82enmADxenD-Mp9HV7eRyPLqKFKUcR1zlmTSMKYp0EtYYQSNznuNMsQzjVEOqeQ6NyrWRjBINmWSSGJ5pE6eakQHYb3MrV74tja_F3HplikIuTLn0IsaEJyRc_gUxwiiJefwPGB4JfQzAQQuVK713JheVs3PpGoGgWPUstBSrnoPc6yKX2dzoH9cVG8BRCz5sYZrfcsTZqIuLWm19bT6_tXSvIvw_ZuL5ZiKmlF_Pnk5n4o58Aa_olBQ</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Martinez, J.M.</creator><creator>Kent, J.M.</creator><creator>Coplan, J.D.</creator><creator>Browne, S.T.</creator><creator>Papp, L.A.</creator><creator>Sullivan, G.M.</creator><creator>Kleber, M.</creator><creator>Perepletchikova, F.</creator><creator>Fyer, A.J.</creator><creator>Klein, D.F.</creator><creator>Gorman, J.M.</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Respiratory variability in panic disorder</title><author>Martinez, J.M. ; Kent, J.M. ; Coplan, J.D. ; Browne, S.T. ; Papp, L.A. ; Sullivan, G.M. ; Kleber, M. ; Perepletchikova, F. ; Fyer, A.J. ; Klein, D.F. ; Gorman, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4462-6cfbae55c41d8fba710eaf6f2bc5b229d04d6f0ecfdea543d05a5a3e6bde79d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Arousal - physiology</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Carbon Dioxide</topic><topic>Cognitive Therapy</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Dose-Response Relationship, Drug</topic><topic>fear</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperventilation - diagnosis</topic><topic>Hyperventilation - physiopathology</topic><topic>Hyperventilation - psychology</topic><topic>Imipramine - administration & dosage</topic><topic>Male</topic><topic>panic disorder</topic><topic>Panic Disorder - diagnosis</topic><topic>Panic Disorder - physiopathology</topic><topic>Panic Disorder - psychology</topic><topic>Panic Disorder - therapy</topic><topic>Premenstrual Syndrome - diagnosis</topic><topic>Premenstrual Syndrome - physiopathology</topic><topic>Premenstrual Syndrome - psychology</topic><topic>Reference Values</topic><topic>respiration</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>trait</topic><topic>variability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez, J.M.</creatorcontrib><creatorcontrib>Kent, J.M.</creatorcontrib><creatorcontrib>Coplan, J.D.</creatorcontrib><creatorcontrib>Browne, S.T.</creatorcontrib><creatorcontrib>Papp, L.A.</creatorcontrib><creatorcontrib>Sullivan, G.M.</creatorcontrib><creatorcontrib>Kleber, M.</creatorcontrib><creatorcontrib>Perepletchikova, F.</creatorcontrib><creatorcontrib>Fyer, A.J.</creatorcontrib><creatorcontrib>Klein, D.F.</creatorcontrib><creatorcontrib>Gorman, J.M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Depression and anxiety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez, J.M.</au><au>Kent, J.M.</au><au>Coplan, J.D.</au><au>Browne, S.T.</au><au>Papp, L.A.</au><au>Sullivan, G.M.</au><au>Kleber, M.</au><au>Perepletchikova, F.</au><au>Fyer, A.J.</au><au>Klein, D.F.</au><au>Gorman, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory variability in panic disorder</atitle><jtitle>Depression and anxiety</jtitle><addtitle>Depress. Anxiety</addtitle><date>2001</date><risdate>2001</risdate><volume>14</volume><issue>4</issue><spage>232</spage><epage>237</epage><pages>232-237</pages><issn>1091-4269</issn><eissn>1520-6394</eissn><abstract>Disordered breathing may play an important role in the pathophysiology of panic disorder. Several studies have now indicated that panic disorder patients have greater respiratory variability than normal controls. In this study, we examine baseline respiratory measures in four diagnostic groups to determine whether greater respiratory variability is specific to panic disorder and whether effective anti‐panic treatment alters respiratory variability. Patients with panic disorder, major depression, or premenstrual dysphoric disorder, and normal control subjects underwent two respiratory exposures (5% and 7% CO2 inhalation), while in a canopy system. Panic disorder patients returned after 12 weeks of either anti‐panic medication or cognitive behavioral therapy, and were retested. Normal control subjects were also retested after a period of 12 weeks. Panic disorder patients had significantly greater respiratory variability at baseline than normal control subjects and patients with major depression. The premenstrual dysphoric patients also had greater variability than the normal control group. Panic disorder patients who panicked to 7% CO2 inhalation had significantly greater baseline variability than panic disorder patients who did not panic. Anti‐panic treatment did not significantly alter baseline respiratory variability. Our data suggest that increased respiratory variability may be an important trait feature for some panic disorder patients and may make them more vulnerable to CO2‐induced panic. Depression and Anxiety 14:232–237, 2001. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11754131</pmid><doi>10.1002/da.1072</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arousal - physiology Autonomic Nervous System - physiopathology Carbon Dioxide Cognitive Therapy Depressive Disorder, Major - diagnosis Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Dose-Response Relationship, Drug fear Female Follow-Up Studies Humans Hyperventilation - diagnosis Hyperventilation - physiopathology Hyperventilation - psychology Imipramine - administration & dosage Male panic disorder Panic Disorder - diagnosis Panic Disorder - physiopathology Panic Disorder - psychology Panic Disorder - therapy Premenstrual Syndrome - diagnosis Premenstrual Syndrome - physiopathology Premenstrual Syndrome - psychology Reference Values respiration Serotonin Uptake Inhibitors - administration & dosage trait variability |
| title | Respiratory variability in panic disorder |
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