Multiple 14G Stereotactic Core Biopsies in the Diagnosis of Mammographically Detected Stellate Lesions of the Breast
AIM: The aim of this retrospective study was to measure the accuracy of stereotactic guided 14 gauge core biopsy in distinguishing between benign and malignant causes of a mammographically detected stellate breast lesion and to assess the impact of the number of core samples taken on the sensitivity...
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| Veröffentlicht in: | Clinical radiology 2000-10, Vol.55 (10), p.763-766 |
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| creator | KIRWAN, S.E. DENTON, E.R.E. NASH, R.M. HUMPHREYS, S. MICHELL, M.J. |
| description | AIM: The aim of this retrospective study was to measure the accuracy of stereotactic guided 14 gauge core biopsy in distinguishing between benign and malignant causes of a mammographically detected stellate breast lesion and to assess the impact of the number of core samples taken on the sensitivity for detection of malignancy
MATERIALS AND METHODS: Seventy-two patients with mammographically detected stellate lesions of the breast formed the study group. All patients in the study group underwent multiple 14 gauge core biopsies using prone stereotactic breast biopsy equipment. The diagnostic accuracy of the technique was measured by retrospectively comparing the outcome with the core biopsy results. The result of each core sample was separately recorded to allow analysis of the effect of increasing the number of samples on accuracy.
RESULTS: Nine of 72 (12%) did not have surgery. Forty of 72 (56%) had a benign surgical outcome and 23/72 (32%) a malignant surgical outcome [7/72 (10%) non-invasive, 16/72 (22%) invasive carcinoma]. The absolute sensitivity for multiple stereotactic guided core biopsies of stellate lesions for the detection of malignancy was 78% with a complete sensitivity of 100%. The sensitivity for the detection of invasive carcinoma was 94% (15 out of 16 patients). No statistically significant improvement in sensitivity was shown for multiple samples vs one sample, but in two patients, malignant tissue was only found in core samples 6–9, the first five cores showing atypia only.
CONCLUSION: Multiple stereotactic guided 14 gauge core biopsies accurately distinguish malignant from benign causes of stellate breast lesions. When core biopsy histology is malignant, therapeutic surgery can be planned. When the core biopsy shows typical features of a benign radial scar, diagnostic surgical excision may not be required to confirm the diagnosis.Kirwan, S. E., (2000). Clinical Radiology55, 763–766. |
| doi_str_mv | 10.1053/crad.2000.0513 |
| format | Article |
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MATERIALS AND METHODS: Seventy-two patients with mammographically detected stellate lesions of the breast formed the study group. All patients in the study group underwent multiple 14 gauge core biopsies using prone stereotactic breast biopsy equipment. The diagnostic accuracy of the technique was measured by retrospectively comparing the outcome with the core biopsy results. The result of each core sample was separately recorded to allow analysis of the effect of increasing the number of samples on accuracy.
RESULTS: Nine of 72 (12%) did not have surgery. Forty of 72 (56%) had a benign surgical outcome and 23/72 (32%) a malignant surgical outcome [7/72 (10%) non-invasive, 16/72 (22%) invasive carcinoma]. The absolute sensitivity for multiple stereotactic guided core biopsies of stellate lesions for the detection of malignancy was 78% with a complete sensitivity of 100%. The sensitivity for the detection of invasive carcinoma was 94% (15 out of 16 patients). No statistically significant improvement in sensitivity was shown for multiple samples vs one sample, but in two patients, malignant tissue was only found in core samples 6–9, the first five cores showing atypia only.
CONCLUSION: Multiple stereotactic guided 14 gauge core biopsies accurately distinguish malignant from benign causes of stellate breast lesions. When core biopsy histology is malignant, therapeutic surgery can be planned. When the core biopsy shows typical features of a benign radial scar, diagnostic surgical excision may not be required to confirm the diagnosis.Kirwan, S. E., (2000). Clinical Radiology55, 763–766.</description><identifier>ISSN: 0009-9260</identifier><identifier>EISSN: 1365-229X</identifier><identifier>DOI: 10.1053/crad.2000.0513</identifier><identifier>PMID: 11052877</identifier><identifier>CODEN: CLRAAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Biopsy, Needle - methods ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Diagnosis, Differential ; Female ; Genital system. Mammary gland ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Mammography ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; radial scar, mammography, core biopsy, stereotaxis ; Retrospective Studies ; Sensitivity and Specificity</subject><ispartof>Clinical radiology, 2000-10, Vol.55 (10), p.763-766</ispartof><rights>2000 The Royal College of Radiologists</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 The Royal College of Radiologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-9968d089ccaa0d114d51193a06b87feeb01847e5e2c8bd8c883e2454ef7025e93</citedby><cites>FETCH-LOGICAL-c369t-9968d089ccaa0d114d51193a06b87feeb01847e5e2c8bd8c883e2454ef7025e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009926000905130$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1530836$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11052877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIRWAN, S.E.</creatorcontrib><creatorcontrib>DENTON, E.R.E.</creatorcontrib><creatorcontrib>NASH, R.M.</creatorcontrib><creatorcontrib>HUMPHREYS, S.</creatorcontrib><creatorcontrib>MICHELL, M.J.</creatorcontrib><title>Multiple 14G Stereotactic Core Biopsies in the Diagnosis of Mammographically Detected Stellate Lesions of the Breast</title><title>Clinical radiology</title><addtitle>Clin Radiol</addtitle><description>AIM: The aim of this retrospective study was to measure the accuracy of stereotactic guided 14 gauge core biopsy in distinguishing between benign and malignant causes of a mammographically detected stellate breast lesion and to assess the impact of the number of core samples taken on the sensitivity for detection of malignancy
MATERIALS AND METHODS: Seventy-two patients with mammographically detected stellate lesions of the breast formed the study group. All patients in the study group underwent multiple 14 gauge core biopsies using prone stereotactic breast biopsy equipment. The diagnostic accuracy of the technique was measured by retrospectively comparing the outcome with the core biopsy results. The result of each core sample was separately recorded to allow analysis of the effect of increasing the number of samples on accuracy.
RESULTS: Nine of 72 (12%) did not have surgery. Forty of 72 (56%) had a benign surgical outcome and 23/72 (32%) a malignant surgical outcome [7/72 (10%) non-invasive, 16/72 (22%) invasive carcinoma]. The absolute sensitivity for multiple stereotactic guided core biopsies of stellate lesions for the detection of malignancy was 78% with a complete sensitivity of 100%. The sensitivity for the detection of invasive carcinoma was 94% (15 out of 16 patients). No statistically significant improvement in sensitivity was shown for multiple samples vs one sample, but in two patients, malignant tissue was only found in core samples 6–9, the first five cores showing atypia only.
CONCLUSION: Multiple stereotactic guided 14 gauge core biopsies accurately distinguish malignant from benign causes of stellate breast lesions. When core biopsy histology is malignant, therapeutic surgery can be planned. When the core biopsy shows typical features of a benign radial scar, diagnostic surgical excision may not be required to confirm the diagnosis.Kirwan, S. E., (2000). Clinical Radiology55, 763–766.</description><subject>Biological and medical sciences</subject><subject>Biopsy, Needle - methods</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mammography</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>radial scar, mammography, core biopsy, stereotaxis</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>0009-9260</issn><issn>1365-229X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EokvhyhH5gLhl8VcS-0i3UJC24gBI3CyvPWmNkjh4vEj99zjsSj1xGs3oeV-NHkJec7blrJXvfXZhKxhjW9Zy-YRsuOzaRgjz8ynZ1LNpjOjYBXmB-GtdlVDPyQWvWaH7fkPK7XEscRmBcnVDvxXIkIrzJXq6SxnoVUwLRkAaZ1rugV5HdzcnjEjTQG_dNKW77Jb76N04PtBrKOALhLVoHF0BugeMaf5Hr_GrDA7LS_JscCPCq_O8JD8-ffy--9zsv9582X3YN152pjTGdDowbbx3jgXOVWg5N9Kx7qD7AeDAuFY9tCC8PgTttZYgVKtg6JlowchL8u7Uu-T0-whY7BTRr5_NkI5oeyG7XnFVwe0J9DkhZhjskuPk8oPlzK6e7erZrp7t6rkG3pybj4cJwiN-FluBt2fAYXUzZDf7iI9cK5mWXcX0CYOq4U-EbNFHmD2EmKtJG1L83wt_Ad0mmUc</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>KIRWAN, S.E.</creator><creator>DENTON, E.R.E.</creator><creator>NASH, R.M.</creator><creator>HUMPHREYS, S.</creator><creator>MICHELL, M.J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Multiple 14G Stereotactic Core Biopsies in the Diagnosis of Mammographically Detected Stellate Lesions of the Breast</title><author>KIRWAN, S.E. ; DENTON, E.R.E. ; NASH, R.M. ; HUMPHREYS, S. ; MICHELL, M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-9968d089ccaa0d114d51193a06b87feeb01847e5e2c8bd8c883e2454ef7025e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy, Needle - methods</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mammography</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>radial scar, mammography, core biopsy, stereotaxis</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIRWAN, S.E.</creatorcontrib><creatorcontrib>DENTON, E.R.E.</creatorcontrib><creatorcontrib>NASH, R.M.</creatorcontrib><creatorcontrib>HUMPHREYS, S.</creatorcontrib><creatorcontrib>MICHELL, M.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIRWAN, S.E.</au><au>DENTON, E.R.E.</au><au>NASH, R.M.</au><au>HUMPHREYS, S.</au><au>MICHELL, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple 14G Stereotactic Core Biopsies in the Diagnosis of Mammographically Detected Stellate Lesions of the Breast</atitle><jtitle>Clinical radiology</jtitle><addtitle>Clin Radiol</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>55</volume><issue>10</issue><spage>763</spage><epage>766</epage><pages>763-766</pages><issn>0009-9260</issn><eissn>1365-229X</eissn><coden>CLRAAG</coden><abstract>AIM: The aim of this retrospective study was to measure the accuracy of stereotactic guided 14 gauge core biopsy in distinguishing between benign and malignant causes of a mammographically detected stellate breast lesion and to assess the impact of the number of core samples taken on the sensitivity for detection of malignancy
MATERIALS AND METHODS: Seventy-two patients with mammographically detected stellate lesions of the breast formed the study group. All patients in the study group underwent multiple 14 gauge core biopsies using prone stereotactic breast biopsy equipment. The diagnostic accuracy of the technique was measured by retrospectively comparing the outcome with the core biopsy results. The result of each core sample was separately recorded to allow analysis of the effect of increasing the number of samples on accuracy.
RESULTS: Nine of 72 (12%) did not have surgery. Forty of 72 (56%) had a benign surgical outcome and 23/72 (32%) a malignant surgical outcome [7/72 (10%) non-invasive, 16/72 (22%) invasive carcinoma]. The absolute sensitivity for multiple stereotactic guided core biopsies of stellate lesions for the detection of malignancy was 78% with a complete sensitivity of 100%. The sensitivity for the detection of invasive carcinoma was 94% (15 out of 16 patients). No statistically significant improvement in sensitivity was shown for multiple samples vs one sample, but in two patients, malignant tissue was only found in core samples 6–9, the first five cores showing atypia only.
CONCLUSION: Multiple stereotactic guided 14 gauge core biopsies accurately distinguish malignant from benign causes of stellate breast lesions. When core biopsy histology is malignant, therapeutic surgery can be planned. When the core biopsy shows typical features of a benign radial scar, diagnostic surgical excision may not be required to confirm the diagnosis.Kirwan, S. E., (2000). Clinical Radiology55, 763–766.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>11052877</pmid><doi>10.1053/crad.2000.0513</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Biopsy, Needle - methods Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Breast Neoplasms - surgery Diagnosis, Differential Female Genital system. Mammary gland Humans Investigative techniques, diagnostic techniques (general aspects) Mammography Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques radial scar, mammography, core biopsy, stereotaxis Retrospective Studies Sensitivity and Specificity |
| title | Multiple 14G Stereotactic Core Biopsies in the Diagnosis of Mammographically Detected Stellate Lesions of the Breast |
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