Blood and Liver Lipid Concentrations in EDS Shrews Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM)
The EDS (early-onset diabetes in suncus) colony was developed as a new laboratory colony of the musk shrew and is characterized by a high incidence of early-onset spontaneous non-insulin dependent diabetes mellitus (NIDDM). We examined blood lipid (triglyceride [TG], total cholesterol [TC], phosphol...
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| Veröffentlicht in: | Experimental Animals 2001, Vol.50(5), pp.427-429 |
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| container_title | Experimental Animals |
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| creator | OHNO, Tamio HORIO, Fumihiko KITOH, Junzoh TANAKA, Shin NISHIMURA, Masahiko NAMIKAWA, Takao |
| description | The EDS (early-onset diabetes in suncus) colony was developed as a new laboratory colony of the musk shrew and is characterized by a high incidence of early-onset spontaneous non-insulin dependent diabetes mellitus (NIDDM). We examined blood lipid (triglyceride [TG], total cholesterol [TC], phospholipid [PL], free fatty acid [FFA]) and liver lipid (TG, TC, PL) concentrations to investigate the features of lipid metabolism in these animals. All lipid concentrations examined both in blood and liver of the diabetic shrews had a tendency toward higher values than those in non-diabetic shrews. The PL concentration was the only parameter that barely showed a significant difference. Values for all blood lipid concentrations in diabetic shrews at 7-9 months tended to be higher than those of 2-month-old diabetic shrews, although the difference was not significant. These findings indicate that diabetic EDS shrews exhibit a much milder defect of lipid metabolism induced by NIDDM than other rodent models. |
| doi_str_mv | 10.1538/expanim.50.427 |
| format | Article |
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We examined blood lipid (triglyceride [TG], total cholesterol [TC], phospholipid [PL], free fatty acid [FFA]) and liver lipid (TG, TC, PL) concentrations to investigate the features of lipid metabolism in these animals. All lipid concentrations examined both in blood and liver of the diabetic shrews had a tendency toward higher values than those in non-diabetic shrews. The PL concentration was the only parameter that barely showed a significant difference. Values for all blood lipid concentrations in diabetic shrews at 7-9 months tended to be higher than those of 2-month-old diabetic shrews, although the difference was not significant. These findings indicate that diabetic EDS shrews exhibit a much milder defect of lipid metabolism induced by NIDDM than other rodent models.</description><identifier>ISSN: 1341-1357</identifier><identifier>EISSN: 1881-7122</identifier><identifier>DOI: 10.1538/expanim.50.427</identifier><identifier>PMID: 11769546</identifier><language>eng</language><publisher>Japan: Japanese Association for Laboratory Animal Science</publisher><subject>Animals ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - veterinary ; Disease Models, Animal ; lipid ; Lipid Metabolism ; Lipids - analysis ; Lipids - blood ; Liver - chemistry ; Male ; non-insulin dependent diabetes mellitus (NIDDM) ; Shrews - physiology ; suncus</subject><ispartof>Experimental Animals, 2001, Vol.50(5), pp.427-429</ispartof><rights>2001 Japanese Association for Laboratory Animal Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c518t-e7f6aadbd09f74a54845c53b2b98513c80cc534091fd27d3f433c3e852f0facb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11769546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OHNO, Tamio</creatorcontrib><creatorcontrib>HORIO, Fumihiko</creatorcontrib><creatorcontrib>KITOH, Junzoh</creatorcontrib><creatorcontrib>TANAKA, Shin</creatorcontrib><creatorcontrib>NISHIMURA, Masahiko</creatorcontrib><creatorcontrib>NAMIKAWA, Takao</creatorcontrib><title>Blood and Liver Lipid Concentrations in EDS Shrews Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM)</title><title>Experimental Animals</title><addtitle>Exp Anim</addtitle><description>The EDS (early-onset diabetes in suncus) colony was developed as a new laboratory colony of the musk shrew and is characterized by a high incidence of early-onset spontaneous non-insulin dependent diabetes mellitus (NIDDM). We examined blood lipid (triglyceride [TG], total cholesterol [TC], phospholipid [PL], free fatty acid [FFA]) and liver lipid (TG, TC, PL) concentrations to investigate the features of lipid metabolism in these animals. All lipid concentrations examined both in blood and liver of the diabetic shrews had a tendency toward higher values than those in non-diabetic shrews. The PL concentration was the only parameter that barely showed a significant difference. Values for all blood lipid concentrations in diabetic shrews at 7-9 months tended to be higher than those of 2-month-old diabetic shrews, although the difference was not significant. These findings indicate that diabetic EDS shrews exhibit a much milder defect of lipid metabolism induced by NIDDM than other rodent models.</description><subject>Animals</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - veterinary</subject><subject>Disease Models, Animal</subject><subject>lipid</subject><subject>Lipid Metabolism</subject><subject>Lipids - analysis</subject><subject>Lipids - blood</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>non-insulin dependent diabetes mellitus (NIDDM)</subject><subject>Shrews - physiology</subject><subject>suncus</subject><issn>1341-1357</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1vEzEQhi0EoqVw5Yh8QnDY1B_rePcI2QCR0vYQOFtee7ZxtbEX24H232O0UdvLjEfz-NHoReg9JQsqeHMJ95P27rAQZFEz-QKd06ahlaSMvSxvXtOKciHP0JuU7ghhUrL2NTqjVC5bUS_P0cPXMQSLtbd46_5ALHVyFq-CN-Bz1NkFn7DzeN3t8G4f4W_C6_u96112_hbvpuCz9hCOCV8HX218Oo6F7mACb4sBd073kCHhKxhHlwv36XrTdVef36JXgx4TvDv1C_Tr2_rn6ke1vfm-WX3ZVkbQJlcgh6XWtrekHWStRd3Uwgjes75tBOWmIaaMNWnpYJm0fKg5NxwawQYyaNPzC_Rx9k4x_D5CyurgkinHzGcryfhSciILuJhBE0NKEQY1RXfQ8UFRov6HrU5hK0FUCbt8-HAyH_sD2Cf8lG4BVjNwl7K-hUdAx-zMCM99Yi5F-7g1ex0VeP4Pcf-Vzw</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>OHNO, Tamio</creator><creator>HORIO, Fumihiko</creator><creator>KITOH, Junzoh</creator><creator>TANAKA, Shin</creator><creator>NISHIMURA, Masahiko</creator><creator>NAMIKAWA, Takao</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Blood and Liver Lipid Concentrations in EDS Shrews Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM)</title><author>OHNO, Tamio ; HORIO, Fumihiko ; KITOH, Junzoh ; TANAKA, Shin ; NISHIMURA, Masahiko ; NAMIKAWA, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-e7f6aadbd09f74a54845c53b2b98513c80cc534091fd27d3f433c3e852f0facb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - veterinary</topic><topic>Disease Models, Animal</topic><topic>lipid</topic><topic>Lipid Metabolism</topic><topic>Lipids - analysis</topic><topic>Lipids - blood</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>non-insulin dependent diabetes mellitus (NIDDM)</topic><topic>Shrews - physiology</topic><topic>suncus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OHNO, Tamio</creatorcontrib><creatorcontrib>HORIO, Fumihiko</creatorcontrib><creatorcontrib>KITOH, Junzoh</creatorcontrib><creatorcontrib>TANAKA, Shin</creatorcontrib><creatorcontrib>NISHIMURA, Masahiko</creatorcontrib><creatorcontrib>NAMIKAWA, Takao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OHNO, Tamio</au><au>HORIO, Fumihiko</au><au>KITOH, Junzoh</au><au>TANAKA, Shin</au><au>NISHIMURA, Masahiko</au><au>NAMIKAWA, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood and Liver Lipid Concentrations in EDS Shrews Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM)</atitle><jtitle>Experimental Animals</jtitle><addtitle>Exp Anim</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>50</volume><issue>5</issue><spage>427</spage><epage>429</epage><pages>427-429</pages><issn>1341-1357</issn><eissn>1881-7122</eissn><abstract>The EDS (early-onset diabetes in suncus) colony was developed as a new laboratory colony of the musk shrew and is characterized by a high incidence of early-onset spontaneous non-insulin dependent diabetes mellitus (NIDDM). We examined blood lipid (triglyceride [TG], total cholesterol [TC], phospholipid [PL], free fatty acid [FFA]) and liver lipid (TG, TC, PL) concentrations to investigate the features of lipid metabolism in these animals. All lipid concentrations examined both in blood and liver of the diabetic shrews had a tendency toward higher values than those in non-diabetic shrews. The PL concentration was the only parameter that barely showed a significant difference. Values for all blood lipid concentrations in diabetic shrews at 7-9 months tended to be higher than those of 2-month-old diabetic shrews, although the difference was not significant. These findings indicate that diabetic EDS shrews exhibit a much milder defect of lipid metabolism induced by NIDDM than other rodent models.</abstract><cop>Japan</cop><pub>Japanese Association for Laboratory Animal Science</pub><pmid>11769546</pmid><doi>10.1538/expanim.50.427</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental Animals, 2001, Vol.50(5), pp.427-429 |
| issn | 1341-1357 1881-7122 |
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| subjects | Animals Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - veterinary Disease Models, Animal lipid Lipid Metabolism Lipids - analysis Lipids - blood Liver - chemistry Male non-insulin dependent diabetes mellitus (NIDDM) Shrews - physiology suncus |
| title | Blood and Liver Lipid Concentrations in EDS Shrews Exhibiting Spontaneous Non-Insulin Dependent Diabetes Mellitus (NIDDM) |
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