Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia
The low affinity neurotrophin receptor (p75) is implicated in promoting oligodendrocytic death after nerve growth factor (NGF) stimulation but NGF and neurotrophin-3 (NT-3) can also potentiate oligodendrocytic survival. We show regional variability in p75 expression within the central nervous system...
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| Veröffentlicht in: | Neuroreport 2001-12, Vol.12 (18), p.4081-4086 |
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| creator | Starkey, G D Petratos, S Shipham, K A Butzkueven, H Bucci, T Lowry, K Cheema, S.-S Kilpatrick, T J |
| description | The low affinity neurotrophin receptor (p75) is implicated in promoting oligodendrocytic death after nerve growth factor (NGF) stimulation but NGF and neurotrophin-3 (NT-3) can also potentiate oligodendrocytic survival. We show regional variability in p75 expression within the central nervous system of the postnatal rat; expression is readily detectable by immunohistochemistry upon a subset of CNPase-positive oligodendroglia in optic nerve but not within the cerebrum. Nevertheless, oligodendroglia isolated from the cerebrum and cultured for 16 hours express p75 as well as the trkC but not the TrkA gene. Viability was not, however, influenced by exposure to either NGF or NT-3. Cells overexpressing p75 remained unresponsive to NGF but exhibited potentiated survival with NT-3, correlating with the differential expression profile of their high affinity receptors. |
| doi_str_mv | 10.1097/00001756-200112210-00044 |
| format | Article |
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We show regional variability in p75 expression within the central nervous system of the postnatal rat; expression is readily detectable by immunohistochemistry upon a subset of CNPase-positive oligodendroglia in optic nerve but not within the cerebrum. Nevertheless, oligodendroglia isolated from the cerebrum and cultured for 16 hours express p75 as well as the trkC but not the TrkA gene. Viability was not, however, influenced by exposure to either NGF or NT-3. 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Psychology ; Gene Expression Regulation, Developmental ; Genetic Vectors ; Immunohistochemistry ; Lac Operon ; Oligodendroglia - chemistry ; Oligodendroglia - cytology ; Oligodendroglia - physiology ; Rats ; Rats, Wistar ; Receptor, Nerve Growth Factor - analysis ; Receptor, Nerve Growth Factor - genetics ; Receptor, trkA - genetics ; Receptor, trkC - analysis ; Receptor, trkC - genetics ; Receptors, Nerve Growth Factor - analysis ; Receptors, Nerve Growth Factor - genetics ; RNA, Messenger - analysis ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2001-12, Vol.12 (18), p.4081-4086</ispartof><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4174-e5a62672b569184686d87956290d69de2ca767115cfd3f3c34356458fdcbe49f3</citedby><cites>FETCH-LOGICAL-c4174-e5a62672b569184686d87956290d69de2ca767115cfd3f3c34356458fdcbe49f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13452189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11742242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Starkey, G D</creatorcontrib><creatorcontrib>Petratos, S</creatorcontrib><creatorcontrib>Shipham, K A</creatorcontrib><creatorcontrib>Butzkueven, H</creatorcontrib><creatorcontrib>Bucci, T</creatorcontrib><creatorcontrib>Lowry, K</creatorcontrib><creatorcontrib>Cheema, S.-S</creatorcontrib><creatorcontrib>Kilpatrick, T J</creatorcontrib><title>Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>The low affinity neurotrophin receptor (p75) is implicated in promoting oligodendrocytic death after nerve growth factor (NGF) stimulation but NGF and neurotrophin-3 (NT-3) can also potentiate oligodendrocytic survival. We show regional variability in p75 expression within the central nervous system of the postnatal rat; expression is readily detectable by immunohistochemistry upon a subset of CNPase-positive oligodendroglia in optic nerve but not within the cerebrum. Nevertheless, oligodendroglia isolated from the cerebrum and cultured for 16 hours express p75 as well as the trkC but not the TrkA gene. Viability was not, however, influenced by exposure to either NGF or NT-3. Cells overexpressing p75 remained unresponsive to NGF but exhibited potentiated survival with NT-3, correlating with the differential expression profile of their high affinity receptors.</description><subject>Adenoviridae - genetics</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Cerebral Cortex - cytology</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic Vectors</subject><subject>Immunohistochemistry</subject><subject>Lac Operon</subject><subject>Oligodendroglia - chemistry</subject><subject>Oligodendroglia - cytology</subject><subject>Oligodendroglia - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Nerve Growth Factor - analysis</subject><subject>Receptor, Nerve Growth Factor - genetics</subject><subject>Receptor, trkA - genetics</subject><subject>Receptor, trkC - analysis</subject><subject>Receptor, trkC - genetics</subject><subject>Receptors, Nerve Growth Factor - analysis</subject><subject>Receptors, Nerve Growth Factor - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYruFv4BygVuW-Ns-ooqPlSq4gAQny7EnbcC1g51s6b_H0MKeEL6M9eqZGesxQg3ubnCn5cuuHiy5aEmtmBDctTVh7AFaYSZpy7n6_BCtOs11y7TgV-i6lK8V0R1Wj9EVxpIRwsgKfXkPS05zTtN-jE0GB9OccgM_pgyljCk2NvqalynFMt5BrGnTn5oplTna2YbGQYY-10sK4y55iD6nXRjtE_RosKHA00tdo09vXn_cvGu3H97ebl5tW8fqK1rgVhAhSc-FxooJJbySmguiOy-0B-KsFBJj7gZPB-ooo1wwrgbvemB6oGv04jx3yun7AmU2h7E4CMFGSEsxktA6nvH_glhRTjinFVRn0OVUSobBTHk82HwyuDO__Js__s1f_-a3_9r67LJj6Q_g7xsvwivw_ALY4mwYso1uLPccZZxgpSvHztwxhRly-RaWI2SzBxvmvfnX_9OfXgad0A</recordid><startdate>20011221</startdate><enddate>20011221</enddate><creator>Starkey, G D</creator><creator>Petratos, S</creator><creator>Shipham, K A</creator><creator>Butzkueven, H</creator><creator>Bucci, T</creator><creator>Lowry, K</creator><creator>Cheema, S.-S</creator><creator>Kilpatrick, T J</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20011221</creationdate><title>Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia</title><author>Starkey, G D ; Petratos, S ; Shipham, K A ; Butzkueven, H ; Bucci, T ; Lowry, K ; Cheema, S.-S ; Kilpatrick, T J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4174-e5a62672b569184686d87956290d69de2ca767115cfd3f3c34356458fdcbe49f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenoviridae - genetics</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Cerebral Cortex - cytology</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic Vectors</topic><topic>Immunohistochemistry</topic><topic>Lac Operon</topic><topic>Oligodendroglia - chemistry</topic><topic>Oligodendroglia - cytology</topic><topic>Oligodendroglia - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Nerve Growth Factor - analysis</topic><topic>Receptor, Nerve Growth Factor - genetics</topic><topic>Receptor, trkA - genetics</topic><topic>Receptor, trkC - analysis</topic><topic>Receptor, trkC - genetics</topic><topic>Receptors, Nerve Growth Factor - analysis</topic><topic>Receptors, Nerve Growth Factor - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Starkey, G D</creatorcontrib><creatorcontrib>Petratos, S</creatorcontrib><creatorcontrib>Shipham, K A</creatorcontrib><creatorcontrib>Butzkueven, H</creatorcontrib><creatorcontrib>Bucci, T</creatorcontrib><creatorcontrib>Lowry, K</creatorcontrib><creatorcontrib>Cheema, S.-S</creatorcontrib><creatorcontrib>Kilpatrick, T J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Starkey, G D</au><au>Petratos, S</au><au>Shipham, K A</au><au>Butzkueven, H</au><au>Bucci, T</au><au>Lowry, K</au><au>Cheema, S.-S</au><au>Kilpatrick, T J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2001-12-21</date><risdate>2001</risdate><volume>12</volume><issue>18</issue><spage>4081</spage><epage>4086</epage><pages>4081-4086</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>The low affinity neurotrophin receptor (p75) is implicated in promoting oligodendrocytic death after nerve growth factor (NGF) stimulation but NGF and neurotrophin-3 (NT-3) can also potentiate oligodendrocytic survival. We show regional variability in p75 expression within the central nervous system of the postnatal rat; expression is readily detectable by immunohistochemistry upon a subset of CNPase-positive oligodendroglia in optic nerve but not within the cerebrum. Nevertheless, oligodendroglia isolated from the cerebrum and cultured for 16 hours express p75 as well as the trkC but not the TrkA gene. Viability was not, however, influenced by exposure to either NGF or NT-3. Cells overexpressing p75 remained unresponsive to NGF but exhibited potentiated survival with NT-3, correlating with the differential expression profile of their high affinity receptors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11742242</pmid><doi>10.1097/00001756-200112210-00044</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenoviridae - genetics Animals Animals, Newborn Biological and medical sciences Cells, Cultured Cerebral Cortex - cytology Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genetic Vectors Immunohistochemistry Lac Operon Oligodendroglia - chemistry Oligodendroglia - cytology Oligodendroglia - physiology Rats Rats, Wistar Receptor, Nerve Growth Factor - analysis Receptor, Nerve Growth Factor - genetics Receptor, trkA - genetics Receptor, trkC - analysis Receptor, trkC - genetics Receptors, Nerve Growth Factor - analysis Receptors, Nerve Growth Factor - genetics RNA, Messenger - analysis Vertebrates: nervous system and sense organs |
| title | Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia |
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