Rapid endotoxin-induced alterations in myocardial calcium handling: Obligatory role of cardiac TNF-α

Bacterial endotoxin (lipopolysaccharide [LPS]) induces septic shock and depressed myocardial contractility. The mechanism of LPS-mediated cardiac dysfunction remains controversial. We hypothesized that LPS exerts significant effects on myocardial excitation-contraction coupling by rapid stimulation...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2001-12, Vol.95 (6), p.1396-1405
Hauptverfasser:	STAMM, Christof, COWAN, Douglas B, FRIEHS, Ingeborg, NORIA, Sabrena, DEL NIDO, Pedro J, MCGOWAN, Francis X
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies, Blocking - pharmacology Biological and medical sciences Calcium - metabolism Emergency and intensive care: infection, septic shock Endotoxins - antagonists & inhibitors Endotoxins - pharmacology In Vitro Techniques Intensive care medicine Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Male Medical sciences Membranes - drug effects Membranes - metabolism Myocardial Contraction - drug effects Myocardium - metabolism Myofibrils - drug effects Myofibrils - metabolism Rats Signal Transduction - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology
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