Improvement of renal dysfunction in rats with chronic heart failure after myocardial infarction by treatment with the endothelin A receptor antagonist, LU 135252

OBJECTIVETo investigate the role of an activated endothelin system in the renal dysfunction observed in chronic heart failure after myocardial infarction. METHODSIn rats with heart failure after myocardial infarction and in sham-operated animals (Sham), we investigated the effect on renal function o...

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Veröffentlicht in:	Journal of hypertension 2000-10, Vol.18 (10), p.1507-1514
Hauptverfasser:	Bauersachs, Johann, Braun, Claude, Fraccarollo, Daniela, Widdera, Julian, Ertl, Georg, Schilling, Lothar, Kirchengast, Michael, Rohmeiss, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Chronic Disease Coronary heart disease Endothelin Receptor Antagonists Endothelins - metabolism Heart Heart Failure - drug therapy Heart Failure - physiopathology Kidney - drug effects Kidney - pathology Kidney - physiopathology Male Medical sciences Myocardial Infarction - complications Myocardial Infarction - drug therapy Phenylpropionates - therapeutic use Pyrimidines - therapeutic use Rats Rats, Wistar Receptor, Endothelin A Receptors, Endothelin - physiology Renal Artery - drug effects Renal Artery - physiopathology Vasodilation - drug effects
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