Kinetics of respiratory system elastance after airway challenge in dogs
1 Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada H2X 2P2; and 2 Vermont Lung Center, The University of Vermont, Burlington, Vermont 05446 We compared the time courses of lung mechanical changes with intravenous (iv) injection vs. aerosol administration of histamine, met...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2000-11, Vol.89 (5), p.2023-2029 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Lauzon, Anne-Marie Bates, Jason H. T |
| description | 1 Meakins-Christie Laboratories, McGill University,
Montreal, Quebec, Canada H2X 2P2; and 2 Vermont Lung Center, The
University of Vermont, Burlington, Vermont 05446
We compared the time courses of lung mechanical changes
with intravenous (iv) injection vs. aerosol administration of
histamine, methacholine, and ACh in dogs. We interpret these
results in terms of a spring-and-dashpot model of airway smooth muscle
receiving activation via a tissue compartment when agonist is delivered by the iv route and through an additional airway wall compartment when
it is delivered by the aerosol route. The model accurately accounts for
the principal features of the respiratory system elastance response
curves. It also accounts for the differences between iv and aerosol
responses, supporting the notion that agonist delivered by aerosol has
to traverse a longer pathway to the airway smooth muscle than does
agonist delivered iv. The time constants representing diffusive
exchange of agonist between compartments were not significantly
different for the three agonists, suggesting that the three agonists
shared a common principal means of clearance, which was presumably
blood flow.
histamine; methacholine; acetylcholine; pulmonary blood flow; bronchial blood flow; pharmacokinetics |
| doi_str_mv | 10.1152/jappl.2000.89.5.2023 |
| format | Article |
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Montreal, Quebec, Canada H2X 2P2; and 2 Vermont Lung Center, The
University of Vermont, Burlington, Vermont 05446
We compared the time courses of lung mechanical changes
with intravenous (iv) injection vs. aerosol administration of
histamine, methacholine, and ACh in dogs. We interpret these
results in terms of a spring-and-dashpot model of airway smooth muscle
receiving activation via a tissue compartment when agonist is delivered by the iv route and through an additional airway wall compartment when
it is delivered by the aerosol route. The model accurately accounts for
the principal features of the respiratory system elastance response
curves. It also accounts for the differences between iv and aerosol
responses, supporting the notion that agonist delivered by aerosol has
to traverse a longer pathway to the airway smooth muscle than does
agonist delivered iv. The time constants representing diffusive
exchange of agonist between compartments were not significantly
different for the three agonists, suggesting that the three agonists
shared a common principal means of clearance, which was presumably
blood flow.
histamine; methacholine; acetylcholine; pulmonary blood flow; bronchial blood flow; pharmacokinetics</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2000.89.5.2023</identifier><identifier>PMID: 11053358</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Acetylcholine - pharmacokinetics ; Administration, Inhalation ; Aerosols - pharmacology ; Animals ; Biological and medical sciences ; Blood ; Bronchoconstrictor Agents - pharmacokinetics ; Dogs ; Elasticity - drug effects ; General pharmacology ; Histamine - pharmacokinetics ; Injections, Intravenous ; Kinetics ; Lung - blood supply ; Lung - drug effects ; Lung - physiology ; Lung Compliance - drug effects ; Lung Compliance - physiology ; Medical sciences ; Methacholine Chloride - pharmacokinetics ; Models, Biological ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Pulmonary Circulation ; Respiratory system ; Vasodilator Agents - pharmacokinetics</subject><ispartof>Journal of applied physiology (1985), 2000-11, Vol.89 (5), p.2023-2029</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-8ff01027cae23758e21cb8e688e4dd3c4f40d6cb7ea15353c187b3fdac34dbad3</citedby><cites>FETCH-LOGICAL-c436t-8ff01027cae23758e21cb8e688e4dd3c4f40d6cb7ea15353c187b3fdac34dbad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=821413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11053358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lauzon, Anne-Marie</creatorcontrib><creatorcontrib>Bates, Jason H. T</creatorcontrib><title>Kinetics of respiratory system elastance after airway challenge in dogs</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Meakins-Christie Laboratories, McGill University,
Montreal, Quebec, Canada H2X 2P2; and 2 Vermont Lung Center, The
University of Vermont, Burlington, Vermont 05446
We compared the time courses of lung mechanical changes
with intravenous (iv) injection vs. aerosol administration of
histamine, methacholine, and ACh in dogs. We interpret these
results in terms of a spring-and-dashpot model of airway smooth muscle
receiving activation via a tissue compartment when agonist is delivered by the iv route and through an additional airway wall compartment when
it is delivered by the aerosol route. The model accurately accounts for
the principal features of the respiratory system elastance response
curves. It also accounts for the differences between iv and aerosol
responses, supporting the notion that agonist delivered by aerosol has
to traverse a longer pathway to the airway smooth muscle than does
agonist delivered iv. The time constants representing diffusive
exchange of agonist between compartments were not significantly
different for the three agonists, suggesting that the three agonists
shared a common principal means of clearance, which was presumably
blood flow.
histamine; methacholine; acetylcholine; pulmonary blood flow; bronchial blood flow; pharmacokinetics</description><subject>Acetylcholine - pharmacokinetics</subject><subject>Administration, Inhalation</subject><subject>Aerosols - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bronchoconstrictor Agents - pharmacokinetics</subject><subject>Dogs</subject><subject>Elasticity - drug effects</subject><subject>General pharmacology</subject><subject>Histamine - pharmacokinetics</subject><subject>Injections, Intravenous</subject><subject>Kinetics</subject><subject>Lung - blood supply</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>Lung Compliance - drug effects</subject><subject>Lung Compliance - physiology</subject><subject>Medical sciences</subject><subject>Methacholine Chloride - pharmacokinetics</subject><subject>Models, Biological</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Circulation</subject><subject>Respiratory system</subject><subject>Vasodilator Agents - pharmacokinetics</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1rFDEUhoModq3-A5GgIN7MNp8z2ctSbJUWvGmvQyZzspslOxmTGer8ezPuUlFobhLI877n8CD0npI1pZJd7M0whDUjhKzVZi3Li_EXaFW-WEVrQl-ilWokqRqpmjP0Juc9IVQISV-jM0qJ5FyqFbq59T2M3mYcHU6QB5_MGNOM85xHOGAIJo-mt4CNGyFh49OjmbHdmRCg3wL2Pe7iNr9Fr5wJGd6d7nP0cP31_upbdffj5vvV5V1lBa_HSjlHKGGNNcB42QwYta2CWikQXcetcIJ0tW0bMFRyyS1VTctdZywXXWs6fo4-H3uHFH9OkEd98NlCCKaHOGXdMF5LrmQBP_4H7uOU-rKbZuUsAjYFEkfIpphzAqeH5A8mzZoSvVjWfyzrxbJWGy31YrnEPpy6p_YA3d_QSWsBPp0Ak60JLhWDPj9xilFBl5ovR2rnt7tHn0APuzn7GOJ2Xgb_M1E8j15PIdzDr3HJPEX00Dn-Gw5dp6I</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Lauzon, Anne-Marie</creator><creator>Bates, Jason H. 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T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-8ff01027cae23758e21cb8e688e4dd3c4f40d6cb7ea15353c187b3fdac34dbad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acetylcholine - pharmacokinetics</topic><topic>Administration, Inhalation</topic><topic>Aerosols - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bronchoconstrictor Agents - pharmacokinetics</topic><topic>Dogs</topic><topic>Elasticity - drug effects</topic><topic>General pharmacology</topic><topic>Histamine - pharmacokinetics</topic><topic>Injections, Intravenous</topic><topic>Kinetics</topic><topic>Lung - blood supply</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>Lung Compliance - drug effects</topic><topic>Lung Compliance - physiology</topic><topic>Medical sciences</topic><topic>Methacholine Chloride - pharmacokinetics</topic><topic>Models, Biological</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Circulation</topic><topic>Respiratory system</topic><topic>Vasodilator Agents - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lauzon, Anne-Marie</creatorcontrib><creatorcontrib>Bates, Jason H. 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Montreal, Quebec, Canada H2X 2P2; and 2 Vermont Lung Center, The
University of Vermont, Burlington, Vermont 05446
We compared the time courses of lung mechanical changes
with intravenous (iv) injection vs. aerosol administration of
histamine, methacholine, and ACh in dogs. We interpret these
results in terms of a spring-and-dashpot model of airway smooth muscle
receiving activation via a tissue compartment when agonist is delivered by the iv route and through an additional airway wall compartment when
it is delivered by the aerosol route. The model accurately accounts for
the principal features of the respiratory system elastance response
curves. It also accounts for the differences between iv and aerosol
responses, supporting the notion that agonist delivered by aerosol has
to traverse a longer pathway to the airway smooth muscle than does
agonist delivered iv. The time constants representing diffusive
exchange of agonist between compartments were not significantly
different for the three agonists, suggesting that the three agonists
shared a common principal means of clearance, which was presumably
blood flow.
histamine; methacholine; acetylcholine; pulmonary blood flow; bronchial blood flow; pharmacokinetics</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11053358</pmid><doi>10.1152/jappl.2000.89.5.2023</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetylcholine - pharmacokinetics Administration, Inhalation Aerosols - pharmacology Animals Biological and medical sciences Blood Bronchoconstrictor Agents - pharmacokinetics Dogs Elasticity - drug effects General pharmacology Histamine - pharmacokinetics Injections, Intravenous Kinetics Lung - blood supply Lung - drug effects Lung - physiology Lung Compliance - drug effects Lung Compliance - physiology Medical sciences Methacholine Chloride - pharmacokinetics Models, Biological Muscle, Smooth - drug effects Muscle, Smooth - physiology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Pulmonary Circulation Respiratory system Vasodilator Agents - pharmacokinetics |
| title | Kinetics of respiratory system elastance after airway challenge in dogs |
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