IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

To identify functions of the IKKalpha subunit of IkappaB kinase that require catalytic activity, we generated an Ikkalpha(AA) knockin allele containing alanines instead of serines in the activation loop. Ikkalpha(AA/AA) mice are healthy and fertile, but females display a severe lactation defect due...

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Veröffentlicht in:	Cell 2001-12, Vol.107 (6), p.763-775
Hauptverfasser:	Cao, Y, Bonizzi, G, Seagroves, T N, Greten, F R, Johnson, R, Schmidt, E V, Karin, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Caseins - genetics Caseins - metabolism Cells, Cultured Cyclin D1 - genetics Cyclin D1 - metabolism Epithelial Cells - metabolism Female Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation Glycoproteins - genetics Glycoproteins - metabolism Humans I-kappa B Kinase Lactation - physiology Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary Glands, Animal - transplantation Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Transgenic NF-kappa B - metabolism Osteoprotegerin Pregnancy Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Tumor Necrosis Factor Signal Transduction Tissue Transplantation Transgenes Tumor Necrosis Factor-alpha - pharmacology
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